DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpB and RIM13

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	NP_013875.1	Gene:	RIM13 / 855186	SGDID:	S000004763	Length:	727	Species:	Saccharomyces cerevisiae

Alignment Length:	683	Identity:	117/683 - (17%)
Similarity:	210/683 - (30%)	Gaps:	244/683 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   317 LAAAANLTQDSTLFFRVIPPDQDFQENYAGI-FHFKFWQYGKWVEVVIDDR----LPTYNGELIY 376
            |...|..::|||....|:.    .:||.:.: ...:|    .|:...|:.|    :|......:.
Yeast    29 LVGLAMKSEDSTFIEAVLV----LKENVSKVDKQLRF----LWLTSTINSRFYPPIPISEASPVS 85

  Fly   377 MHSTEKNEFWSALLEKAY---AKLHGSYEALKGGTTCEAMEDFTGGV------------------ 420
            .:.||.....:..|::.|   |||...             ||::||:
Yeast    86 WNKTEYCAPGTEELQRRYPGRAKLQNE-------------EDYSGGIEQCRDVPDCSLVASLINL 137

  Fly   421 ---------------TEWY---------------DIKEAPPNL------------------FSIM 437
                           |:::               ||.:.|.::                  .:::
Yeast   138 RSKNLNLPLIKQISSTKYHVNLSFNGSNKRLVTVDISQIPTSVDGKQLSLKSNDISDKIGELALL 202

  Fly   438 MKAAERGSMMGCSLEPDPHVLEAETPQGLIRGHAYSITK--------VCLMDISTPNRQGKLPMI 494
            :.:....|..|.::..|.:.|....|: :.:.::|...|        :|||...|.||...
Yeast   203 LVSKGTYSTDGSNISIDTYRLSGFLPE-ITQVNSYPFEKLWKFHKSNLCLMGAGTGNRSND---- 262

  Fly   495 RMRNPWGNDAEWSGPWSDSSPEWRFIPEHTKEEIGLNFDRDGEFWMSFQDFLNHFDRVEICNLSP 559
             |..|...:.::|  ..|.:.:.|.:.........||.:      :|::.:|.:|.::.: |.:.
Yeast   263 -MIKPLVENHDYS--IIDITYDSRLVKLRDPRNSALNVE------ISYEQYLKNFKQLYL-NWNQ 317

  Fly   560 DSLTEDQQHSSRRKWEMSMFEGEWTSGVTAGGCRNFLETFWHNPQYIISLEDPDDEDDDGKCTAI 624
            :.|.:..|....|                       .:|..:|...|::.:......::.|.|..
Yeast   318 EKLFKRSQVLHFR-----------------------YDTSRYNKFSIVADKPLFHLVNNSKVTET 359

  Fly   625 VALMQKNRRSKRNVGIDCLTIGFAIYHLTDRDMQVKPQGLNFFKYRASVARSPHFINTREVCARF 689
            |.|:.::                   ||.|...|..              ||..|:|....|...
Yeast   360 VWLLLES-------------------HLQDEGSQEN--------------RSVSFLNEAPECIIC 391

  Fly   690 KLPP-----GHYL---IVPSTFDPNEEGEFIIRVFSETRNNMEEND----DEVGFGETDD----- 737
            .:.|     |:::   :|....|  .|.|.::..:|.|.||...:.    .|:.|....|
Yeast   392 PIEPPVECGGNHIGLQLVKLRLD--AETERLLYCYSTTNNNFSIHSFSVVKEICFQRLKDTKSLF 454

  Fly   738 -RIAPSLPPPTPKEEDDPQRIALRRLFDSVAGSDEEVDWQELKRILDHSMRDVMVGSDG-----F 796
             ::..|.          |..|..:..||:...........|:     ||.:|..|..|.     .
Yeast   455 AKVLFSF----------PYEIEGKASFDTCNFFQNPTFELEV-----HSEQDYQVLMDAACISTS 504

  Fly   797 SKDAVRSMV-----------AMLDKDRSGRLGFEEFEALLTDIAKWRAV-----------FKLYD 839
            |.|.:...|           .|.|.......|.::...:||:: |:..|           |:|..
Yeast   505 SHDLINIQVYYFNDYELIKPIMFDNHYQPGQGLKQDVPILTNV-KYMIVCSTYGPPASTEFELLA 568

  Fly   840 TRRTGS----IDGFHLRGA---LNSAGYHLNNR 865
            :.|..|    |.|..||..   ..:..||..||
Yeast   569 SIRLSSSWRLISGITLRSVNLIYGTYPYHCRNR 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042	51/320 (16%)
		Calpain_III	574..721	CDD:279416	24/154 (16%)
		EF-hand_7	759..825	CDD:290234	14/81 (17%)
		EFh	761..826	CDD:298682	14/80 (18%)
		FRQ1	827..>908	CDD:227455	14/57 (25%)
RIM13	NP_013875.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810