DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpB and PEF1

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	NP_011572.2	Gene:	PEF1 / 852949	SGDID:	S000003290	Length:	335	Species:	Saccharomyces cerevisiae

Alignment Length:	210	Identity:	48/210 - (22%)
Similarity:	90/210 - (42%)	Gaps:	27/210 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   738 RIAPSLPPPTPKEEDDPQRIALRRLFDSVAGSDEEV-------------DWQELKRILDHSMRDV 789
            |||.| |||....:..|.:: |:::..:...|.|:|             |.:...|:....::::
Yeast   123 RIASS-PPPLIHNQAVPAQL-LKKVAPASFDSREDVRDMQVATQLFHNHDVKGKNRLTAEELQNL 185

  Fly   790 MVGSDG--FSKDAVRSMVAMLDKDRSGRLGFEEFEALLTDIAKWRAVFKLYDTR--RTGSIDGFH 850
            :...|.  |...:|.:::.:....|.|.:...||.||...:..||.|:...|..  .|.|:..||
Yeast   186 LQNDDNSHFCISSVDALINLFGASRFGTVNQAEFIALYKRVKSWRKVYVDNDINGSLTISVSEFH 250

  Fly   851 LRGALNSAGYHLNNRLLNALAHRYG---SREG---QIPFDDFLMCAIKVRTFIEMFRERDTDNSD 909
              .:|...||.:...:......:|.   :|.|   ::.||.|:...:.:....::||:.||:...
Yeast   251 --NSLQELGYLIPFEVSEKTFDQYAEFINRNGTGKELKFDKFVEALVWLMRLTKLFRKFDTNQEG 313

  Fly   910 TAFFNLDDWLERTIY 924
            .|.....|:::.|:|
Yeast   314 IATIQYKDFIDATLY 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042
		Calpain_III	574..721	CDD:279416
		EF-hand_7	759..825	CDD:290234	14/80 (18%)
		EFh	761..826	CDD:298682	14/79 (18%)
		FRQ1	827..>908	CDD:227455	21/88 (24%)
PEF1	NP_011572.2	EFh_PEF_Group_I	161..329	CDD:320055	36/170 (21%)
		EF-hand motif	161..190	CDD:320055	2/28 (7%)
		EF-hand motif	198..227	CDD:320055	7/28 (25%)
		EF-hand motif	228..257	CDD:320055	9/30 (30%)
		EF-hand motif	264..298	CDD:320055	6/33 (18%)
		EF-hand motif	300..328	CDD:320055	7/27 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I3060
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910