DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CalpB and capn12

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	XP_005173727.1	Gene:	capn12 / 799247	ZFINID:	ZDB-GENE-050419-245	Length:	717	Species:	Danio rerio

Alignment Length:	729	Identity:	257/729 - (35%)
Similarity:	391/729 - (53%)	Gaps:	88/729 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 DFQSLRDSCLANGTMFEDPDFPATNASLMYSRRPD--RYYEWLRPGDIADDPQFFVEG-YSRFDV 306
            |::.|..:||.:..:|.|..|.|..:||.....||  :..:||||.:|..: ..|||| ....|:
Zfish    17 DYEVLLQTCLKSAVLFSDSVFAANQSSLGLPADPDPKKAVKWLRPKEITSN-AVFVEGTMGTTDI 80

  Fly   307 QQGELGDCWLLAAAANLTQDSTLFFRVIPPDQDFQENYAGIFHFKFWQYGKWVEVVIDDRLPTYN 371
            .||:||:||||||.:.||...|||.:|:|..|...|:|||||.|||||||:|||||:|||||...
Zfish    81 CQGQLGNCWLLAALSCLTMHPTLFVKVVPAGQSLSESYAGIFRFKFWQYGEWVEVVVDDRLPVRE 145

  Fly   372 GELIYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGGVTEWYDIKEAPPN-LFS 435
            |.|::.:|...|||||||:|||||||.|||.:||||...|.|||||||:.....:...||. |:.
Zfish   146 GRLLFSYSRTSNEFWSALVEKAYAKLIGSYGSLKGGIISEGMEDFTGGIAYSLPVSSRPPRMLWK 210

  Fly   436 IMMKAAERGSMMGCSLEPDPHVLEAE-----TPQGLIRGHAYSITKVCLMDISTPNRQGKLP--- 492
            .:..|..|.|::.|.:    |....:     ||:|||:||||:||:.           ||:.
Zfish   211 AITAALARNSLLSCFI----HATTVKDIGTVTPEGLIKGHAYAITET-----------GKVKKAS 260

  Fly   493 ----MIRMRNPWGNDAEWSGPWSDSSPEWRFIPEHTKEEIGLNFDRDGEFWMSFQDFLNHFDRVE 553
                ::|:||||| ..|:.|||||...:|.|:....|.::.|....|||||:|.:||...::.||
Zfish   261 EEVFLLRLRNPWG-FVEYCGPWSDKCKDWDFVDNTEKTKLELAKVEDGEFWISIEDFCRFYNTVE 324

  Fly   554 ICNLSPDSLT-EDQQHSSRRKWEMSMFEGEWTSGVTAGGCRNFLETFWHNPQY--IISLEDPDDE 615
            :|::.|||:: |:.:.:|...|.:|:.:|.|....:|||.|.:.::||.||||  |:|.:|.||.
Zfish   325 MCSVDPDSMSGEESEDTSTSSWTLSLHQGTWVPMCSAGGSRRYPKSFWKNPQYQMILSEKDVDDH 389

  Fly   616 D-------DDG--------------------------KCTAIVALMQKNRRSKRNVGIDCLTIGF 647
            |       |||                          |||.:|.|:||.||.|..|..  |.|.|
Zfish   390 DYGEGEEGDDGGDGEEDEDVSLLPPVSKTSKPGEKKKKCTVLVELLQKYRRQKDKVNF--LYIAF 452

  Fly   648 AIYHLTDRDMQVKPQGLN--FFKYRASVARSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGE 710
            .||.:.. :::..|..|:  ||....:::||..:.:.|.|..:..|.||.|:|:.||:.||::||
Zfish   453 HIYKVPP-ELKDSPGSLDQQFFSSNRAISRSGKYRSIRSVWRKVHLEPGSYVILASTYRPNQQGE 516

  Fly   711 FIIRVFSETRNNMEENDDEVGFGETDDRIAPSLPPPTPKEEDDPQRIALRRLFDSVAGSDEEVDW 775
            |.:|::::|.|.....|    |..|::..|..:..|...|  |..|:  ::.|:..|||||.|:.
Zfish   517 FFLRIYTKTGNIQGFQD----FPCTNNYSAMVMSKPVLPE--DQYRV--QKWFEEKAGSDERVNA 573

  Fly   776 QELKRILDHSMRDVMVGSDGFSKDAVRSMVAMLDKDRSGRLGFEEFEALLTDIAKWRAVFKLYDT 840
            .:...:::    .|:........:..|.::...|....|||...:.|.||:.:...:::|..:|.
Zfish   574 VQFMNLVN----SVLEKDYELPLETCRQLIFGEDTGGRGRLDRAQAEKLLSSLRNLQSIFFQFDE 634

  Fly   841 RRTGSIDGFHLRGALNSAGYHLNNRLLNALAHRYGSREGQIPFDDFLMCAIKVRTFIEMFRERDT 905
            ..:|::..|.|..|||:||...::.::..|..|:|:.|..:||..|:.|..:::...::: |.:|
Zfish   635 DSSGTMSPFELSLALNAAGVECDSVVVQMLWERFGAGEQYLPFYGFVSCVARLQVLFDLY-EAET 698

  Fly   906 DNSDTAFFNLDDWL 919
             |.:.....::.||
Zfish   699 -NQEVKDKGINAWL 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042	138/311 (44%)
		Calpain_III	574..721	CDD:279416	61/183 (33%)
		EF-hand_7	759..825	CDD:290234	14/65 (22%)
		EFh	761..826	CDD:298682	15/64 (23%)
		FRQ1	827..>908	CDD:227455	20/80 (25%)
capn12	XP_005173727.1	Peptidase_C2	32..327	CDD:279042	138/311 (44%)
capn12	XP_005173727.1	Calpain_III	346..527	CDD:279416	61/183 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580196
Domainoid	1	1.000	78	1.000	Domainoid score	I8692
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.810