DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpB and capn8.1

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	XP_031757616.1	Gene:	capn8.1 / 733929	XenbaseID:	XB-GENE-920785	Length:	1515	Species:	Xenopus tropicalis

Alignment Length:	698	Identity:	316/698 - (45%)
Similarity:	444/698 - (63%)	Gaps:	46/698 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 DFQSLRDSCLANGTMFEDPDFPATNASLMYSR-----RPDRYYEWLRPGDIADDPQFFVEGYSRF 304
            ||:.||..|||:||:|:|.:|||..::|.::.     ...:...|.||.:|..:|||.|:|.:|.
Frog    32 DFEKLRAQCLASGTLFKDEEFPACPSALGFNELGPGSPKTQGVIWKRPSEICPNPQFIVDGATRG 96

  Fly   305 DVQQGELGDCWLLAAAANLTQDSTLFFRVIPPDQDFQENYAGIFHFKFWQYGKWVEVVIDDRLPT 369
            |::||.|||||||||.|:||.|:.|..:|:|.:|.||::|||||||:|||||:||:||:||||||
Frog    97 DIRQGALGDCWLLAAIASLTLDADLVAQVVPENQSFQKDYAGIFHFRFWQYGEWVDVVVDDRLPT 161

  Fly   370 YNGELIYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGGVTEWYDIKEAPPNLF 434
            .||.|:::||.|.:||||||||||||||:||||||.||:|.|..||||||:.|.|::::||.:||
Frog   162 KNGNLVFVHSAEGDEFWSALLEKAYAKLNGSYEALSGGSTIEGFEDFTGGIAEVYELRKAPSDLF 226

  Fly   435 SIMMKAAERGSMMGCSLE-PDPHVLEAETPQGLIRGHAYSITKVCLMDISTPNRQGKLPMIRMRN 498
            .|:.||....|::|||:: .:.:..||.|.:.|::|||||:|..  .::....||.||  ||:||
Frog   227 QIIQKALRAESLLGCSIDITNAYDTEAITSRKLVKGHAYSVTGA--EEVLYRGRQEKL--IRVRN 287

  Fly   499 PWGNDAEWSGPWSDSSPEWRFIPEHTKEEIGLNFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLT 563
            ||| :.||:|||||::|||.:|....|..:....| ||||||:|.|||..:.|:||||||||:||
Frog   288 PWG-EVEWTGPWSDTAPEWNYIDPKVKAALDKQSD-DGEFWMAFSDFLREYSRLEICNLSPDTLT 350

  Fly   564 EDQQHSSRRKWEMSMFEGEWTSGVTAGGCRNFLETFWHNPQYIISLEDPDDE----DDDGKCTAI 624
            ..:||    ||.::::.|.|..|.|||||:|:..|||.|||:.|.|:|||.|    :.:..||.|
Frog   351 NTEQH----KWNITLYNGSWARGSTAGGCQNYPATFWTNPQFRIKLDDPDHEHQGSNQEPCCTVI 411

  Fly   625 VALMQKNRRSKRNVGIDCLTIGFAIYHL-------TDRDMQVKPQGLNFFKYRASVARSPHFINT 682
            |.|||||||.|:.:|.|.|:||::::.:       ||..:     |.:||:...:.|||..:||.
Frog   412 VGLMQKNRRRKKKMGEDLLSIGYSLFKIPNQLQNHTDDHL-----GRDFFQKTPTAARSDTYINV 471

  Fly   683 REVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETRNNMEENDDEVGFGETDDRIAPSLPPPT 747
            |||..||.||.|.||||||||:|.:.|:|.:|||||    .|....|||    |..||   .|..
Frog   472 REVSNRFHLPVGDYLIVPSTFEPFKNGDFCLRVFSE----KEAKSLEVG----DVVIA---KPYE 525

  Fly   748 PKEEDDPQRIALRRLFDSVAGSDEEVDWQELKRILDH--SMRDVMVGSDGFSKDAVRSMVAMLDK 810
            ||..:.......:.:||.:||..||:|.:||:.||:.  |.|..: .|:||:.:..|.|:::.|.
Frog   526 PKISNKDVTDEFKNIFDKLAGDKEEIDAKELQTILNKLISKRPDL-RSNGFTVNTCREMISLQDM 589

  Fly   811 DRSGRLGFEEFEALLTDIAKWRAVFKLYDTRRTGSIDGFHLRGALNSAGYHLNNRLLNALAHRYG 875
            |.:..|...||..|...|.|:.|::...|:.|:|::|...||.||..||:.|||::..::..||.
Frog   590 DGTATLSLLEFRILWLKIQKYLAIYLKADSDRSGTMDAHELRAALQEAGFTLNNKIQQSIVLRYA 654

  Fly   876 SREGQIPFDDFLMCAIKVRTFIEMFRERDTDNSDTAFFNLDDWLERTI 923
            |.|..|.||.|:.|.:::.|..:||:..|.........:|.:||..|:
Frog   655 SDELTINFDSFIACMMRLETLFKMFQMLDKSKKGVVELSLQEWLCATL 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042	156/301 (52%)
		Calpain_III	574..721	CDD:279416	73/157 (46%)
		EF-hand_7	759..825	CDD:290234	23/67 (34%)
		EFh	761..826	CDD:298682	24/66 (36%)
		FRQ1	827..>908	CDD:227455	29/80 (36%)
capn8.1	XP_031757616.1	Peptidase_C2	47..343	CDD:395523	156/301 (52%)
		Calpain_III	355..515	CDD:238132	76/172 (44%)
		EFh_PEF_CAPN8	536..702	CDD:320066	56/166 (34%)
		Peptidase_C2	809..1106	CDD:395523
		Calpain_III	1127..1268	CDD:395848
		EFh_PEF	1298..1515	CDD:355382
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	361	1.000	Domainoid score	I950
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	643	1.000	Inparanoid score	I801
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	1	1.000	-	-		mtm9483
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060