Protein Alignment CalpB and CAPN5

DIOPT Version :9

• Sequence 1: NP_001246706.1
• Gene: CalpB / 39165
• FlyBaseID: FBgn0025866
• Length: 925
• Species: Drosophila melanogaster
• Sequence 2: XP_011543527.1
• Gene: CAPN5 / 726
• HGNCID: 1482
• Length: 680
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 219/570 - (38%)
• Similarity: 310/570 - (54%)
• Gaps: 94/570 - (16%)

  Fly   191 PTAPPPESAPTQEEEPSVGVAELSFTSVKVPENQNMFWMGRKATSARQNSVSKGDFQSLRDSCLA 255
            |...||         |..|.|...|:.||..|:||                    :.:||..|..
Human    27 PRGVPP---------PLPGAAATMFSCVKPYEDQN--------------------YSALRRDCRR 62

  Fly   256 NGTMFEDPDFPATNASLMYSRRPDRYYEWLRPGDIADDPQFFVEGYSRFDVQQGELGDCWLLAAA 320
            ...:||||.||||:.||.|...|.....|.||..|.:||:.||:|.|..|:.||::|:||.:||.
Human    63 RKVLFEDPLFPATDDSLYYKGTPGPAVRWKRPKGICEDPRLFVDGISSHDLHQGQVGNCWFVAAC 127

  Fly   321 ANLTQDSTLFFRVIPPDQDFQEN---------YAGIFHFKFWQYGKWVEVVIDDRLPTYNGELIY 376
            ::|....:|:.:|||   |::|.         |||||||.||::|:||:|||||||||.|.:|||
Human   128 SSLASRESLWQKVIP---DWKEQEWDPEKPNAYAGIFHFHFWRFGEWVDVVIDDRLPTVNNQLIY 189

  Fly   377 MHSTEKNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGGVTEWYDIKEAP--------PNL 433
            .||..:||||.||:|||||||.|.|:||.||.|.:|:.||||||:|..|:.|..        ..|
Human   190 CHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGDFANDETKRNQL 254

  Fly   434 FSIMMKAAERGSMMGCSLEPDPHV-LEAETPQGLIRGHAYSITKVCLMDISTPNRQG-------- 489
            |..|:|...||.::..|::..... :||....||::||||::|.|..:      |.|
Human   255 FERMLKVHSRGGLISASIKAVTAADMEARLACGLVKGHAYAVTDVRKV------RLGHGLLAFFK 313

  Fly   490 --KLPMIRMRNPWGNDAEWSGPWSDSSPEWRFIPEHTKEEIGLNFDRDGEFWMSFQDFLNHFDRV 552
              ||.|||:||||| :.||:|||||:|.||:.:.:..:|::|:....||||||:|:|...:|..:
Human   314 SEKLDMIRLRNPWG-EREWNGPWSDTSEEWQKVSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDI 377

  Fly   553 EICNLSPDSLTEDQQHSSRRK-WEMSMFEGEWT-----SGVTAGGCRNFLETFWHNPQYIISLED 611
            ..|.:...|      |.|..| ||.:...|.||     .....|||.|..:||:.|||||..::.
Human   378 IKCRVINTS------HLSIHKTWEEARLHGAWTLHEDPRQNRGGGCINHKDTFFQNPQYIFEVKK 436

  Fly   612 PDDEDDDGKCTAIVALMQKNRRSKRNVGI-DCLTIGFAIYHLTDRDMQVKPQGLNFFKYRASVAR 675
            |:||       .::.:.|:.:||.|..|. :.|.|||.||.: :.:.|.:...|   :::|:
Human   437 PEDE-------VLICIQQRPKRSTRREGKGENLAIGFDIYKV-EENRQYRMHSL---QHKAA--- 487

  Fly   676 SPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETRNNMEE 725
            |..:||:|.|..|...|.|.|:|:|:||:|...|||::|||::..:|..|
Human   488 SSIYINSRSVFLRTDQPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCRE 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403	10/33 (30%)
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042	144/323 (45%)
		Calpain_III	574..721	CDD:279416	53/152 (35%)
		EF-hand_7	759..825	CDD:290234
		EFh	761..826	CDD:298682
		FRQ1	827..>908	CDD:227455
CAPN5	XP_011543527.1	CysPc	53..391	CDD:128526	151/353 (43%)
		Calpain_III	394..533	CDD:279416	53/152 (35%)
		C2_Calpain	555..678	CDD:176011

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920