DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CalpB and zgc:136872

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	NP_001035341.1	Gene:	zgc:136872 / 678524	ZFINID:	ZDB-GENE-060421-5204	Length:	693	Species:	Danio rerio

Alignment Length:	701	Identity:	256/701 - (36%)
Similarity:	377/701 - (53%)	Gaps:	60/701 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 DFQSLRDSCLANGTMFEDPDFPATNASLMYS--RRPDRY-YEWLRPGDIADDPQFFVEGYSRFDV 306
            |||.|:..||.....|.|..||....|:...  :|.|.: ..|.||.::..:|.:..:|.||||.
Zfish    33 DFQQLKQFCLKERLRFRDNLFPPELKSIGLGPLKRDDLWKVVWKRPYELVPNPVYIAQGTSRFDF 97

  Fly   307 QQGELGDCWLLAAAANLTQDSTLFFRVIPPDQDFQENYAGIFHFKFWQYGKWVEVVIDDRLPTYN 371
            .||.||:||.||:...||....:..:||..||.|..:|||||||:||::|.||:|||||:|||.:
Zfish    98 IQGRLGNCWFLASVGALTFQKRIMKQVIQDDQTFSVDYAGIFHFRFWRFGSWVDVVIDDKLPTID 162

  Fly   372 GELIYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGGVTEWYDIKEAPPNLFSI 436
            .:|:::.|...||||.|||||||||:.|||..:..|...||:.|||||......:.:|...|:.|
Zfish   163 NQLVFVQSKTPNEFWPALLEKAYAKVCGSYADMDAGNISEALMDFTGGPHMTIKLSQASDKLWDI 227

  Fly   437 MMKAAERGSMMGCSLEPDPHVLEAET--PQGLIRGHAYSITKVCLMDISTPNRQGKLPMIRMRNP 499
            |.:|.:..|:|||........:...|  |.||:..|||::|.|  .::....|..||  :|:.||
Zfish   228 MRRAGQSESLMGCGTPGGQAGVLQNTVLPNGLVEMHAYTVTGV--TEVVCKGRPVKL--VRIFNP 288

  Fly   500 WGNDAEWSGPWSDSSPEWRFI-PEHTKEEIGLNFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLT 563
            ||: .||:..|||.||.|..: ||..|....|:   :||||||.:||..:|..::||....:.|.
Zfish   289 WGS-GEWNRDWSDRSPLWELVRPEDQKYNDVLD---NGEFWMSMEDFCRNFSEMDICCSDVNVLA 349

  Fly   564 EDQQHSSRRKWEMSMFEGEWTSGVTAGGCRNFLETFWHNPQYIISL-EDPDDEDDDGKCTAIVAL 627
            ..|..|    |:..:.:|:|..|.|||||.|.:::|..||||.::| |..:|..|......:|:|
Zfish   350 GSQSSS----WKTEVHKGQWVMGTTAGGCSNDIDSFSKNPQYRVTLKETVEDPRDKSSANLLVSL 410

  Fly   628 MQKNRRSKRNVGIDCLTIGFAIY----HLTDRDMQVKPQGLNFFKYRASVARSPHFINTREVCAR 688
            :||:.:..|::..: ..|||.||    ||.|   |.:....:||:....|.::..|:|.|||...
Zfish   411 IQKSHKRNRHLATN-FHIGFNIYEVPAHLKD---QKEKFPASFFRNVRVVGKNESFLNAREVMEF 471

  Fly   689 FKLPPGHYLIVPSTFDPNEEGEFIIRVFSETRNNMEENDDEVGFGETDDRIAPSLPPPTPKEEDD 753
            |:...|.||||||||.|||...|::.|:|:|...:|   |..|:|.|..::       .|::.|:
Zfish   472 FRFKAGDYLIVPSTFQPNEASSFLLTVYSKTETIIE---DTSGYGITRTKM-------IPRDNDE 526

  Fly   754 PQRIALRRLFDSVAGSDEEVDWQELKRILD---HSMRDVMVGSDGFSKDAVRSMVAMLDKDRSGR 815
            .     .:||...|....|||.:.|:::|:   |:.|...  :.|||.|..:|:||::|...:||
Zfish   527 S-----FQLFLQYADKYGEVDAERLQKLLNENLHAGRSQK--TTGFSVDLCKSLVALMDLSVTGR 584

  Fly   816 LGFEEFEALLTDIAKW-RAVFK---LY--DTRRTGSIDGFHLRGALNSAGYHLNNRLLNALAHRY 874
            |  .|||.|    ..| ||||.   .|  |...|||:....||.||..||:.|::.:||.:|.||
Zfish   585 L--SEFECL----RLWKRAVFLKDIFYDMDVSHTGSLSVNELRNALKVAGFVLSDGMLNLMALRY 643

  Fly   875 GSREGQIPFDDFLMCAIKVRTFIEMFRERDTDNSDTAFFNLDDWLERTIYS 925
            ....|:|..::|::..:::....:.|: |.:..........::|:..|:||
Zfish   644 ADSNGEISLENFIVLVLRMDCMAKTFK-RLSAGGPNMMLGENEWMHLTLYS 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042	125/301 (42%)
		Calpain_III	574..721	CDD:279416	58/151 (38%)
		EF-hand_7	759..825	CDD:290234	24/68 (35%)
		EFh	761..826	CDD:298682	25/67 (37%)
		FRQ1	827..>908	CDD:227455	27/86 (31%)
zgc:136872	NP_001035341.1	Peptidase_C2	48..341	CDD:279042	124/300 (41%)
		Calpain_III	356..504	CDD:279416	58/151 (38%)
		EFh	600..659	CDD:298682	20/58 (34%)
		EF-hand_7	600..656	CDD:290234	19/55 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	78	1.000	Domainoid score	I8692
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.880