DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CalpB and SRI

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	NP_003121.1	Gene:	SRI / 6717	HGNCID:	11292	Length:	198	Species:	Homo sapiens

Alignment Length:	176	Identity:	66/176 - (37%)
Similarity:	100/176 - (56%)	Gaps:	7/176 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   745 PPTPKEEDDPQRIALRRLFDSVAGSDEEVDWQELKRILDHSMRDVMVGSDGFSKDAVRSMVAMLD 809
            |..|.:..||    |...|.:|||.|.::|..||:|.|..|  .:..|...|:.:..|.||:|||
Human    25 PAFPGQTQDP----LYGYFAAVAGQDGQIDADELQRCLTQS--GIAGGYKPFNLETCRLMVSMLD 83

  Fly   810 KDRSGRLGFEEFEALLTDIAKWRAVFKLYDTRRTGSIDGFHLRGALNSAGYHLNNRLLNALAHRY 874
            :|.||.:||.||:.|...:..||..|..:||.|:|::|...|:.||.:.|:.|:.:.:|::|.||
Human    84 RDMSGTMGFNEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQAVNSIAKRY 148

  Fly   875 GSREGQIPFDDFLMCAIKVRTFIEMFRERDTDNSDTAFFNLDDWLE 920
             |..|:|.|||::.|.:|:|...:.||.|||.......|..||:::
Human   149 -STNGKITFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQ 193

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042
		Calpain_III	574..721	CDD:279416
		EF-hand_7	759..825	CDD:290234	27/65 (42%)
		EFh	761..826	CDD:298682	27/64 (42%)
		FRQ1	827..>908	CDD:227455	31/80 (39%)
SRI	NP_003121.1	EFh_PEF_sorcin	34..198	CDD:320062	63/167 (38%)
		EF-hand motif	34..62	CDD:320062	13/33 (39%)
		EF-hand motif	74..103	CDD:320062	14/28 (50%)
		EF-hand motif	104..133	CDD:320062	11/28 (39%)
		EF-hand motif	140..167	CDD:320062	12/27 (44%)
		EF-hand motif	169..197	CDD:320062	8/25 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910