DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpB and CAPN15

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	XP_011520922.1	Gene:	CAPN15 / 6650	HGNCID:	11182	Length:	1162	Species:	Homo sapiens

Alignment Length:	855	Identity:	205/855 - (23%)
Similarity:	304/855 - (35%)	Gaps:	279/855 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 EGGGAPK-----PKAGLYPSLPYPSSESVGGMPYVVKQTSHAQNASYAGPTMGMGMPVPEAPS-- 93
            ||...|:     |:..|: :.|..||.||.|.|   ::.|..:.     |...:.:|...||:
Human   206 EGAAEPRGGWACPRCTLH-NTPVASSCSVCGGP---RRLSLPRI-----PPEALVVPEVVAPAGF 261

  Fly    94 --APAPYPSATPYPGSGLYPSLPSANVSSLPYP--TAPMAPYPTGM---PYPTGMPQ--PNLPYP 149
              .||..|...|..|:...|...|...::.|.|  ..|.:|:.:.:   |.|....:  |.| .|
Human   262 HVVPAAPPPGLPGEGAEANPPATSQGPAAEPEPPRVPPFSPFSSTLQNNPVPRSRREVPPQL-QP 325

  Fly   150 AAPLAPYPSAMPGLPGMP----------------------------------------------- 167
            ..|.|..||...|..|.|
Human   326 PVPEAAQPSPSAGCRGAPQGSGWAGASRLAELLSGKRLSVLEEEATEGGTSRVEAGSSTSGSDII 390

  Fly   168 ------MPYAP-MPTSPAPQHNIGFP-------ALPYPTAPPPESA---------------PTQ- 202
                  :.|.| .|:||      .|.       .|..||..|..||               ||.
Human   391 DLAGDTVRYTPASPSSP------DFTTWSCAKCTLRNPTVAPRCSACGCSKLHGFQEHGEPPTHC 449

  Fly   203 ----EEEP-----SVGVAELSFTSVKV-PEN--------------------------QNMFWMGR 231
                .::|     |.|....:..:.:| ||.                          |.:....|
Human   450 PDCGADKPSPCGRSCGRVSSAQKAARVLPERPGQWACPACTLLNALRAKHCAACHTPQLLVAQRR 514

  Fly   232 KATSAR---------QNSVSKGDFQSLRDS----CLANGTMFEDPDFPATNASLMY---SRRPDR 280
            .|...|         :....:|:.::|.::    |..|...|.|..||....|:.:   .....|
Human   515 GAAPLRRRESMHVEQRRQTDEGEAKALWENIVAFCRENNVSFVDDSFPPGPESVGFPAGDSVQQR 579

  Fly   281 YYEWLRPGDIADDPQFFVE---GYSRF------DVQQGELGDCWLLAAAANLTQDSTLFFRVIPP 336
            ..:||||.:|  :...|.:   .:|.|      |:.||.||:||.|:|.|.|.:...|..||:..
Human   580 VRQWLRPQEI--NCSVFRDHRATWSVFHTLRPSDILQGLLGNCWFLSALAVLAERPDLVERVMVT 642

  Fly   337 DQDFQENYAGIFHFKFWQYGKWVEVVIDDRLPTYNGELIYMHSTEKNEFWSALLEKAYAKLHGSY 401
            .....|   |.:..:..:.|.|..|::||.||......:.....::.:.|.||:|||.|||||||
Human   643 RSLCAE---GAYQVRLCKDGTWTTVLVDDMLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSY 704

  Fly   402 EALKGGTTCEAMEDFTGGVTEWYDIKEAPPN----------LFSIMMKAAERGSMMGCS-----L 451
            .||:.|...|.:...||...|...::.:..|          :::.|:.:.|.|.:||.|     :
Human   705 FALQAGRAIEGLATLTGAPCESLALQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNM 769

  Fly   452 EPDPHVLEAETPQGLIRGHAYSITKVCLMDISTPNRQGKLPMIRMRNPWGNDAEWSGPWSDSSPE 516
            :.|....|:   .||...|||||..|  .|:     || ..::|:|||||. ..|:|.|||..|.
Human   770 KVDDSAYES---LGLRPRHAYSILDV--RDV-----QG-TRLLRLRNPWGR-FSWNGSWSDEWPH 822

  Fly   517 WRFIPEHTKEEIGLNFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQHSSRRKWEMSMFEG 581
            |   |.|.:.|:..:...:|.|||.:.||:.:||.|:||.:..|             |:.:..:|
Human   823 W---PGHLRGELMPHGSSEGVFWMEYGDFVRYFDSVDICKVHSD-------------WQEARVQG 871

  Fly   582 EWTS------GVTAGGCRNFLETFWHNPQYIISLEDPDDEDDDGKCTAIVALMQKNRRSKRNVGI 640
            .:.|      ||||   ...||.        .|||              .||.|:.  |:|:..:
Human   872 CFPSSASAPVGVTA---LTVLER--------ASLE--------------FALFQEG--SRRSDAV 909

  Fly   641 DCLTIGFAIYHLTDRDMQVKPQGLNFFKYRASVARSPH------FINTREVCARF-----KLPPG 694
            |.        ||.|         |....:||:.....|      ..:::....:|     .|.||
Human   910 DS--------HLLD---------LCILVFRATFGSGGHLSLGRLLAHSKRAVKKFVSCDVMLEPG 957

  Fly   695 HYLIVPSTFD 704
            .|.:|...|:
Human   958 EYAVVCCAFN 967

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403	60/317 (19%)
		Drf_FH1	37..189	CDD:283903	45/228 (20%)
		Peptidase_C2	260..556	CDD:279042	103/322 (32%)
		Calpain_III	574..721	CDD:279416	32/148 (22%)
		EF-hand_7	759..825	CDD:290234
		EFh	761..826	CDD:298682
		FRQ1	827..>908	CDD:227455
CAPN15	XP_011520922.1	ZnF_RBZ	73..97	CDD:197784
		RanBP2-type Zn finger	75..94	CDD:275376
		RanBP2-type Zn finger	116..135	CDD:275376
		RanBP2-type Zn finger	169..191	CDD:275375
		ZnF_RBZ	213..237	CDD:197784	8/24 (33%)
		RanBP2-type Zn finger	215..234	CDD:275375	6/19 (32%)
		RanBP2-type Zn finger	412..431	CDD:275376	5/18 (28%)
		ZnF_RBZ	482..506	CDD:197784	0/23 (0%)
		RanBP2-type Zn finger	484..503	CDD:275376	0/18 (0%)
		CysPc	544..859	CDD:238004	105/334 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820