DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpB and Capn10

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	NP_113861.1	Gene:	Capn10 / 63834	RGDID:	69354	Length:	666	Species:	Rattus norvegicus

Alignment Length:	503	Identity:	165/503 - (32%)
Similarity:	235/503 - (46%)	Gaps:	78/503 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   259 MFEDPDFPATNASLMYSR-------RPDRYYEWLRPGDIADDPQFFVEGYSRFDVQQGELGDCWL 316
            :|.|..|||:::||.|:.       |.|  ..|.||.||...||.|.:......|:||.|||||.
  Rat    13 LFRDAAFPASDSSLFYNLSTPLAQFRED--ITWRRPQDICATPQLFPDNPWEGQVKQGLLGDCWF 75

  Fly   317 LAAAANLTQDSTLFFRVIPPDQD--FQENYAGIFHFKFWQYGKWVEVVIDDRLPTYNGELIYMHS 379
            |.|.|.|.:...|..:|.||.|.  ..:.|.|.|..:.||:|.|.||.||||||...|.|.:...
  Rat    76 LCACAALQKSRHLLDQVFPPGQPGWSDQEYQGFFTCRIWQFGHWEEVTIDDRLPCLAGRLCFSRC 140

  Fly   380 TEKNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGGVTEWYDIKEAPPNLFSIMMKAA--- 441
            ..::.||..||||||||:|||||.|..|...:|:.|.||.:.|.:.:|:        :.||:
  Rat   141 QREDVFWLPLLEKAYAKVHGSYEHLWAGQVADALVDLTGSLAERWSLKD--------IRKASGQQ 197

  Fly   442 ERGS-----------------MMGCS-LEPDPHVLEAETPQGLIRGHAYSITKVCLMDISTPNRQ 488
            :|.|                 ::.|| |.|.....|      |...||:.|:.  |.::.:...|
  Rat   198 DRPSGGEHRACQQLLRLKDQCLLSCSVLSPRAGARE------LGEFHAFIISD--LQELRSQTGQ 254

  Fly   489 GKLPMIRMRNPWGNDAEWSGPWSDSSPEWRFIPEHTKEEIGLNFDRDGEFWMSFQDFLNHFDRVE 553
            |.| ::|:.||||... |.|.|.:....|..: |..||...|...::||||:..::||..||.|.
  Rat   255 GIL-LLRIHNPWGRRC-WQGLWREGGEGWNQV-EPAKESELLAQLQEGEFWVEEEEFLREFDEVT 316

  Fly   554 ICNLSPDSLTEDQQHSSRRKWEMSMFEGEWTSGVTAGGCRNFLETFWHNPQYIISLEDPDDEDDD 618
            |.....::......::.:.........|.|.:|.:|||||| ...|..||::.:.|.:|.:
  Rat   317 IGYPVTEAGHLQSLYTEKVLCHTRALPGAWVTGQSAGGCRN-NSCFPCNPKFWLRLLEPSE---- 376

  Fly   619 GKCTAIVALMQKNRRSKRNVGIDCLTIGF--AIYHLTDRDMQVKPQGLNFFKYRASVARSPHFIN 681
                ..||::|:.||  |.||......|.  |..:|..:|.|.  .||:.:|........|..::
  Rat   377 ----VCVAVLQRPRR--RLVGQTRALAGASPAPVNLPGKDYQA--VGLHIWKVEKRKISLPRVLS 433

  Fly   682 T------------REVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFS 717
            .            ||:..|.:|.||:||.|||||..:..|:|::||||
  Rat   434 APPVAGTACHAYDREIHLRCELSPGYYLAVPSTFLKDVPGQFLLRVFS 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042	115/325 (35%)
		Calpain_III	574..721	CDD:279416	50/158 (32%)
		EF-hand_7	759..825	CDD:290234
		EFh	761..826	CDD:298682
		FRQ1	827..>908	CDD:227455
Capn10	NP_113861.1	CysPc	8..319	CDD:238004	115/326 (35%)
		Domain III 1	322..488		50/173 (29%)
		calpain_III	338..488	CDD:214786	50/157 (32%)
		Calpain_III	506..647	CDD:238132
		Domain III 2	507..648
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920