Protein Alignment CalpB and Capn12

DIOPT Version :10

• Sequence 1: NP_524016.4
• Gene: CalpB / 39165
• FlyBaseID: FBgn0025866
• Length: 925
• Species: Drosophila melanogaster
• Sequence 2: NP_001104277.1
• Gene: Capn12 / 60594
• MGIID: 1891369
• Length: 720
• Species: Mus musculus
• Alignment Length: 693
• Identity: 258/693 - (37%)
• Similarity: 390/693 - (56%)
• Gaps: 56/693 - (8%)

  Fly   234 TSARQNSVSKG-DFQSLRDSCLANGTMFEDPDFPATNASLMYSR-RPD----RYYEWLRPGDIAD 292
            |.|....:.|| :::::|.:||.:|.:|.||.|||...:|.|.: .||    :..||.||.:...
Mouse    19 TGAGGPQLFKGQNYEAIRRACLDSGILFRDPCFPAGPDALGYDKLGPDSEKAKGVEWKRPHEFCA 83

  Fly   293 DPQFFVEGYSRFDVQQGELGDCWLLAAAANLTQDSTLFFRVIPPDQDFQENYAGIFHFKFWQYGK 357
            :|||..|..||.||.||.||:||||||||:||....|.:||:||.|.||:.|||:|||:.||:|:
Mouse    84 EPQFICEDMSRTDVCQGSLGNCWLLAAAASLTLYPRLLYRVVPPGQGFQDGYAGVFHFQLWQFGR 148

  Fly   358 WVEVVIDDRLPTYNGELIYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGGVTE 422
            ||:||:||:||...|:|:::.|.::||||:.||||||||||||||.::||...||..||||||.|
Mouse   149 WVDVVVDDKLPVREGKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGHMNEAFVDFTGGVGE 213

  Fly   423 WYDIKEAPPNLFSIMMKAAERGSMMGCSLEPDPHVLEAETPQGLIRGHAYSITKVCLMDISTPNR 487
            ...:::..|.:|:.:..|..:.|::|.:...|..  |..|.:||::|||||:|....|.:...
Mouse   214 VLYLRQNTPGVFAALRHALAKESLVGATALSDRG--EIRTDEGLVKGHAYSVTGTHKMSLGFT-- 274

  Fly   488 QGKLPMIRMRNPWGNDAEWSGPWSDSSPEWRFIPEHTKEEIGLNFDRDGEFWMSFQDFLNHFDRV 552
              |:.::|:|||||. .|||||||||.|.|..:|...::.: |....||||||..||||.||:.|
Mouse   275 --KVRLLRLRNPWGR-VEWSGPWSDSCPRWDMLPSEWRDAL-LVKKEDGEFWMELQDFLTHFNTV 335

  Fly   553 EICNLSPDSLTEDQQHSSRRKWEMSMFEGEWTSGVTAGGCRNFLETFWHNPQYIISLEDPDDEDD 617
            :||:|||:.|........   |.:.:|:|.|..|..:||.:...|.||.|||:.::|.:||:|:|
Mouse   336 QICSLSPEVLGPSPAGGG---WHIHIFQGRWVRGFNSGGSQPSAENFWTNPQFRLTLLEPDEEED 397

  Fly   618 DG------------------------KCTAIVALMQKNRRSKRNVGIDCLTIGFAIYHLTDR--D 656
            |.                        |||.:::|:|:|||..|..|:..||:||.::.:.:.  |
Mouse   398 DDDEEGPWGGWGAAGARGPARGGRVPKCTVLLSLIQRNRRCLRAKGLTYLTVGFHVFQIPEELLD 462

  Fly   657 MQVKPQGLNFFKYRASVARSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETRN 721
            :...|:............||. |...|:|..|.:|||||||:|||.....:|.:|.:|:|||..:
Mouse   463 LWDSPRSRALLPGLLRADRSV-FCARRDVSRRCRLPPGHYLVVPSASRVGDEADFTLRIFSERSH 526

  Fly   722 NMEENDDEVGFGETDDRIAPSLPPPTPKEEDDPQRIALRRLFDSVAGSDEEVDWQELKRILDHSM 786
            ...|.||.:. .:.|...||.          .|..:.|.:||..:||.:||::..:|:.::..::
Mouse   527 TAVEIDDVIS-ADLDALQAPY----------KPLELELAQLFLELAGEEEELNALQLQTLISIAL 580

  Fly   787 RDVMVGSDGFSKDAVRSMVAMLD-KDRSGRLGFEEFEALLTDIAKWRAVFKLYDTRRTGSIDGFH 850
            ......:....:..:|:...::. ..|..||....|:.|...:..|:|.|..:|...:|:::...
Mouse   581 EPARANTRTPGEIGLRTCEQLVQCFGRGQRLSLHHFQELWGHLMSWQATFDKFDEDASGTMNSCE 645

  Fly   851 LRGALNSAGYHLNNRLLNALAHRYGSREGQIPFDDFLMCAIKV 893
            ||.||.:||:||||:|..:|..||.....::.|:.|:.||.::
Mouse   646 LRLALTAAGFHLNNQLTQSLTSRYRDSRLRVDFERFVCCAARL 688

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_524016.4	PHA03247	<40..207	CDD:223021
		Peptidase_C2	260..556	CDD:459889	144/300 (48%)
		Calpain_III	579..716	CDD:460050	53/162 (33%)
		EFh_PEF_CalpA_B	758..925	CDD:320071	37/137 (27%)
		EF-hand motif	758..786	CDD:320071	8/27 (30%)
		EF-hand motif	799..829	CDD:320071	6/30 (20%)
		EF-hand motif	830..860	CDD:320071	10/29 (34%)
		EF-hand motif	866..894	CDD:320071	8/28 (29%)
		EF-hand motif	895..925	CDD:320071
Capn12	NP_001104277.1	Peptidase_C2	46..339	CDD:459889	144/300 (48%)
		Domain III	342..541		62/203 (31%)
		Calpain_III	352..531	CDD:238132	57/182 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	393..415		4/21 (19%)
		Domain IV	542..720		40/157 (25%)
		EFh_PEF	568..720	CDD:355382	30/121 (25%)
		EF-hand motif	597..624	CDD:320054	5/26 (19%)
		EF-hand motif	625..654	CDD:320054	9/28 (32%)
		EF-hand motif	661..689	CDD:320054	8/28 (29%)
		EF-hand motif	691..719	CDD:320054