DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpB and capn10

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	XP_009297070.1	Gene:	capn10 / 570311	ZFINID:	ZDB-GENE-110411-137	Length:	649	Species:	Danio rerio

Alignment Length:	679	Identity:	192/679 - (28%)
Similarity:	277/679 - (40%)	Gaps:	166/679 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   259 MFEDPDFPATNASLMY------SRRPDRYYEWLRPGDIADDPQFFVEGYSRFDVQQGELGDCWLL 317
            ||.|.||||.:.||.:      |:..|. ..||||.:|...||.|.:.......:||.|||||||
Zfish    10 MFVDLDFPADDPSLFWDYTTPLSKLLDD-VTWLRPQEICQQPQLFPDDPLEAHPKQGILGDCWLL 73

  Fly   318 AAAANLTQDSTLFFRVIPPDQDF--QENYAGIFHFKFWQYGKWVEVVIDDRLPTYNGELIYMHST 380
            .|.:.|.::..|..:|.||:|..  ...|.|.|.|:|||.|.|:||.:|||||..|..|.:....
Zfish    74 CACSMLLKNQHLLDKVFPPEQPLWGDSAYRGEFLFRFWQNGHWIEVRVDDRLPCINDNLCFSRCQ 138

  Fly   381 EKNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGGVTEWYDIK--EAP--PN--------- 432
            ....||.|||||||||||||||.|..|..||||.|.:|.|...:.||  |:|  ||
Zfish   139 SPRAFWVALLEKAYAKLHGSYEHLWAGQVCEAMVDLSGAVAVRWSIKDPESPQQPNDSQIQHALH 203

  Fly   433 ---LFSIMMKAAERGSMMGCSLEPDPHVLEAETPQGLIRGHAYSITKVCLMD---ISTPNRQGKL 491
               :..:.::..||     |::....|......|: |.:.||     :|:|:   ::|...:| :
Zfish   204 GLSVSDLPLELKER-----CAISCCVHSATTGFPE-LGQFHA-----MCVMEWTSVTTITGEG-V 256

  Fly   492 PMIRMRNPWGNDAEWSGPWSDSSPEWRFIPEHTKEEIGLNFDRDGEFWMSFQDFLNHFDRVEI-C 555
            .:||:|||||. ..|:|.|.:....|..:.....:.: |:....|||||...:||..||.|.: |
Zfish   257 QLIRIRNPWGR-RSWAGVWRERGSGWASLEASCAQTL-LSRTAKGEFWMDEAEFLQEFDEVTVGC 319

  Fly   556 NLSP----------DSLTEDQQHSSRRKWEMSMFEGEWTSGVTAGGCRNFLETFWHNPQYIISLE 610
            .::.          :.||..||           ..|.|..|.:|||||| ..||..||::.:.:.
Zfish   320 PVNDAGHLQSIYTGNFLTHSQQ-----------IGGRWVKGYSAGGCRN-NSTFSSNPKFWLKVC 372

  Fly   611 DPDDEDDDGKCTAIVALMQKNRRSKRNVGIDCLTIGFAIYHLTDRDMQVKPQGLNFFKYRASVAR 675
            :..:        ..::|:|..|......|        ||...|    |::...|:.:|     ..
Zfish   373 ERGE--------VFLSLLQCRRAESPAEG--------AIQQHT----QLQAIALHVWK-----VE 412

  Fly   676 SPHFINT----------------REVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETRNNME 724
            ..||..|                |||.....|.||.||:|||||....||.|::||.|....::.
Zfish   413 KKHFNLTRTLNKQPFVSHAHAYDREVVVHTHLNPGFYLLVPSTFLQGAEGPFLLRVHSSCSTSLS 477

  Fly   725 ENDDEVGFGETDDRIAPSLPPPTPKEEDDPQRIALRRLFDSVAGSDEEVDWQELKRILDHSMRDV 789
                          :..|.|.|..                    ...|.:|:.:......|:...
Zfish   478 --------------VMKSSPSPLQ--------------------LSSEGEWENICSHGSWSIGSS 508

  Fly   790 MVGSDGFSKDAVRSMVAMLDKDRSGRLGFEEFEALLTDIAKWRAVFKLYDTRRTGSID--GFHL- 851
            ..||..|:...:...|.:               .::.|.........|:..|...|:.  |||:
Zfish   509 AGGSRNFTTHELNPRVNL---------------TVIYDPGGNNVRVTLHQNRPENSLHPIGFHIY 558

  Fly   852 ------RGALNSAGYHLNNRLLNALAHRY 874
                  .|:|.|.|  :.:.:::.:.|.|
Zfish   559 KVPDGGSGSLLSPG--VMSPVVSCVPHAY 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042	118/323 (37%)
		Calpain_III	574..721	CDD:279416	45/162 (28%)
		EF-hand_7	759..825	CDD:290234	7/65 (11%)
		EFh	761..826	CDD:298682	7/64 (11%)
		FRQ1	827..>908	CDD:227455	13/57 (23%)
capn10	XP_009297070.1	CysPc	11..317	CDD:238004	118/320 (37%)
		calpain_III	337..477	CDD:214786	48/176 (27%)
		Calpain_III	492..619	CDD:294111	19/111 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.020