DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CalpB and si:dkeyp-50d11.2

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	XP_009293787.1	Gene:	si:dkeyp-50d11.2 / 565825	ZFINID:	ZDB-GENE-091113-22	Length:	704	Species:	Danio rerio

Alignment Length:	702	Identity:	314/702 - (44%)
Similarity:	433/702 - (61%)	Gaps:	54/702 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 DFQSLRDSCLANGTMFEDPDFPATNASLMY-----SRRPDRYYEWLRPGDIADDPQFFVEGYSRF 304
            ||:|||..||.:|.:|||..|||..:||.:     :....|...|:||.:...||.|.|:|.:|.
Zfish    36 DFESLRTRCLQSGHLFEDDIFPAQQSSLGFKELGPNSSKTRGVRWMRPTEFCSDPHFIVDGATRT 100

  Fly   305 DVQQGELGDCWLLAAAANLTQDSTLFFRVIPPDQDFQENYAGIFHFKFWQYGKWVEVVIDDRLPT 369
            |:.||.|||||||||.|.||.:..|..||:|..|.|.:.|||||||:|||:|.||:||||||||.
Zfish   101 DICQGALGDCWLLAAIACLTLNEPLLRRVVPHGQSFHQQYAGIFHFQFWQFGDWVDVVIDDRLPV 165

  Fly   370 YNGELIYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGGVTEWYDIKEAPPNLF 434
            .:|:|:::||.|.:||||||:|||||||:|.||||.||:|.|..|||||||||.|::|.||||||
Zfish   166 RDGKLLFVHSAEGSEFWSALVEKAYAKLNGCYEALSGGSTSEGFEDFTGGVTEMYELKNAPPNLF 230

  Fly   435 SIMMKAAERGSMMGCSLEPDPHV-LEAETPQGLIRGHAYSITKVCLMDISTPNRQGKLPMIRMRN 498
            ||:.:|.||||:||||::..... :||.|.:.|::|||||||.|..::.    |:.:..::|:||
Zfish   231 SIITRAVERGSLMGCSIDITSFFDMEAITFKKLVKGHAYSITGVDEVEY----RRSQTKLLRIRN 291

  Fly   499 PWGNDAEWSGPWSDSSPEWRFIPEHTKEEIGLNFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLT 563
            ||| :.||:|||||.|.|||.|....:..:. |...||||||:|.||...|.|:|||||:.|:|
Zfish   292 PWG-EVEWTGPWSDESKEWREIDASVRSRLH-NCQEDGEFWMAFSDFKREFSRLEICNLTADAL- 353

  Fly   564 EDQQHSSRRKWEMSMFEGEWTSGVTAGGCRNFLETFWHNPQYIISLEDPDDEDDDGKCTAIVALM 628
               |....:||..|::.|||..|.|||||||:..|||.|||:.|.|::||.::.:| ||.:||||
Zfish   354 ---QSREVKKWNSSLYPGEWRRGSTAGGCRNYPATFWINPQFKIVLKEPDTDNQEG-CTFLVALM 414

  Fly   629 QKNRRSKRNVGIDCLTIGFAIY------------HLTDRDMQVKPQGLNFFKYRASVARSPHFIN 681
            |||||..|..|.|..|||||||            || .||         ||....|.|||..|||
Zfish   415 QKNRRQLRREGKDMETIGFAIYEVPKEYLGRVGVHL-KRD---------FFLKHTSSARSELFIN 469

  Fly   682 TREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETRNNMEENDDEVGFGETDDRIAPSLPPP 746
            .|||.:||.||.|.|:||||||:|.:||:|::|||||...:.:|.|||         |:..:|..
Zfish   470 LREVSSRFSLPAGEYIIVPSTFEPQKEGDFVLRVFSEKATDSQELDDE---------ISADVPEE 525

  Fly   747 TPKEEDDPQRIALRRLFDSVAGSDEEVDWQELKRILDHSM---RDVMVGSDGFSKDAVRSMVAML 808
            ...:|.|... ..:.||..:||.:.|::..:|:.||:..:   :|:.  :|||.|:..|.|:.::
Zfish   526 PVLQESDIDE-GFKALFAKLAGPEMEINVAKLEMILNRVVSKHKDIK--TDGFGKETCRGMINLM 587

  Fly   809 DKDRSGRLGFEEFEALLTDIAKWRAVFKLYDTRRTGSIDGFHLRGALNSAGYHLNNRLLNALAHR 873
            |...:|:||..:|..|.....::.|||:.:|..::|::..:.:|.||.|||:.|.|.|...:..|
Zfish   588 DTTGTGKLGLTDFHVLWEKFKRYLAVFREFDIDKSGTMSSYEMRLALESAGFKLTNNLFQLIILR 652

  Fly   874 YGSREGQIPFDDFLMCAIKVRTFIEMFRERDTDNSDTAFFNLDDWLERTIYS 925
            |...:..:.||:|:.|.|::.|..:.|:..|.|......|:...|:..|:::
Zfish   653 YAKSDLNVDFDNFVACLIRLETMFKTFKTLDADEDGLVSFSFAQWITLTMFT 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042	160/301 (53%)
		Calpain_III	574..721	CDD:279416	82/158 (52%)
		EF-hand_7	759..825	CDD:290234	20/68 (29%)
		EFh	761..826	CDD:298682	21/67 (31%)
		FRQ1	827..>908	CDD:227455	25/80 (31%)
si:dkeyp-50d11.2	XP_009293787.1	Peptidase_C2	51..347	CDD:279042	160/301 (53%)
		Calpain_III	361..507	CDD:279416	81/156 (52%)
		EF1B	500..563	CDD:294128	21/72 (29%)
		EFh	580..630	CDD:298682	13/49 (27%)
		EFh	612..667	CDD:238008	19/54 (35%)
		EF-hand_7	613..698	CDD:290234	25/84 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	358	1.000	Domainoid score	I921
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	656	1.000	Inparanoid score	I755
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	1	1.000	-	-		mtm6388
orthoMCL	1	0.900	-	-		OOG6_100404
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.970