DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpB and capn1b

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	XP_005174088.1	Gene:	capn1b / 565106	ZFINID:	ZDB-GENE-060503-491	Length:	704	Species:	Danio rerio

Alignment Length:	695	Identity:	320/695 - (46%)
Similarity:	446/695 - (64%)	Gaps:	42/695 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 DFQSLRDSCLANGTMFEDPDFPATNASLMYSR-RPD----RYYEWLRPGDIADDPQFFVEGYSRF 304
            |::.||..|:.:|.:||||.|||...||.:.. .|:    |..:|:||.:::::|||.|.|.:|.
Zfish    34 DYEELRRECVESGRLFEDPCFPAVPQSLGFKELAPNSSKTRGVKWIRPTELSENPQFIVGGATRT 98

  Fly   305 DVQQGELGDCWLLAAAANLTQDSTLFFRVIPPDQDFQENYAGIFHFKFWQYGKWVEVVIDDRLPT 369
            |:.||.|||||||||.|:||.:..|..||:|..|.|...|||||||:|||:|:||::|||||||.
Zfish    99 DICQGALGDCWLLAAIASLTLNDKLLHRVVPHGQSFTNEYAGIFHFQFWQFGEWVDIVIDDRLPV 163

  Fly   370 YNGELIYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGGVTEWYDIKEAPPNLF 434
            .:.||:::||.|.|||||||||||||||:||||||.||:|.|..|||||||.|.|:::.||.:|.
Zfish   164 KDKELMFVHSAEGNEFWSALLEKAYAKLNGSYEALSGGSTTEGFEDFTGGVAEMYELRSAPKDLH 228

  Fly   435 SIMMKAAERGSMMGCSLE-PDPHVLEAETPQGLIRGHAYSITKVCLMDISTPNRQGKLPMIRMRN 498
            .|:.||.||||::|||:: .....:||.|.:.|::|||||:|  .|.:::....:.:|  ||:||
Zfish   229 RIIAKALERGSLLGCSIDITSAFDMEAVTFKKLVKGHAYSVT--ALREVNFRGNRERL--IRIRN 289

  Fly   499 PWGNDAEWSGPWSDSSPEWRFIPEHTKEEIGLNFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLT 563
            ||| ..||:|.|||:|.||..|....:||:. |...|||||||||:|...|.|:|||||:||:|:
Zfish   290 PWG-QVEWTGAWSDNSSEWNGIDPSEREELN-NHMEDGEFWMSFQEFKRQFSRLEICNLTPDALS 352

  Fly   564 EDQQHSSRRKWEMSMFEGEWTSGVTAGGCRNFLETFWHNPQYIISL--EDPDDEDDDGKCTAIVA 626
            :|.||.    |....|.|.|..|.|||||||...|||.||||.|:|  ||.|.||::..||.:||
Zfish   353 DDSQHF----WNTIQFNGTWRKGSTAGGCRNNPNTFWINPQYKITLLEEDDDPEDNEVACTFMVA 413

  Fly   627 LMQKNRRSKRNVGIDCLTIGFAIYHLTD-----RDMQVKPQGLNFFKYRASVARSPHFINTREVC 686
            ||||:||..|..|.|..|||||:|.:.|     :::.:|.   :||...:|.|||..|||.|||.
Zfish   414 LMQKDRRRFRKQGQDMHTIGFALYEVPDEFLGSQNVHLKK---DFFLRHSSCARSETFINLREVS 475

  Fly   687 ARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETRNNMEENDDEVGFGETDDRIAPSLPPPTPKEE 751
            .|.:||||.||||||||:|.:|.:|::|||:|.::..:|.|||:.|...|:.       ...:|.
Zfish   476 TRLRLPPGEYLIVPSTFEPGKEADFVLRVFTEKQSETQEMDDEISFNLEDEE-------AVSEEN 533

  Fly   752 DDPQRIALRRLFDSVAGSDEEVDWQELKRILDHSM---RDVMVGSDGFSKDAVRSMVAMLDKDRS 813
            .|   .:.:::|..::|.|.|:...||:.||:..|   ||:.  :||||.::.|.|:.::|||.|
Zfish   534 ID---ASFKKMFAQLSGEDMEISVHELRTILNRVMTKHRDLK--TDGFSLESCRCMINLMDKDGS 593

  Fly   814 GRLGFEEFEALLTDIAKWRAVFKLYDTRRTGSIDGFHLRGALNSAGYHLNNRLLNALAHRYGSRE 878
            .|||..||:.|...|.||..||:.:|..::|::..:.:|.|:.|||:.|||:|...|..||...:
Zfish   594 ARLGIVEFQILWNKIRKWLGVFRQFDLDKSGTMSSYEMRLAVESAGFKLNNKLHQILVARYSDGD 658

  Fly   879 GQIPFDDFLMCAIKVRTFIEMFRERDTDNSDTAFFNLDDWLERTI 923
             .|.||:|:.|.:|:....:.|:|.:.:.|..|..|:.:||..|:
Zfish   659 -VIDFDNFVCCLVKLEAMFKSFKELEKEGSGVAELNISEWLYLTM 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042	159/301 (53%)
		Calpain_III	574..721	CDD:279416	79/153 (52%)
		EF-hand_7	759..825	CDD:290234	26/68 (38%)
		EFh	761..826	CDD:298682	27/67 (40%)
		FRQ1	827..>908	CDD:227455	27/80 (34%)
capn1b	XP_005174088.1	Peptidase_C2	49..345	CDD:279042	159/301 (53%)
		Calpain_III	359..510	CDD:279416	79/153 (52%)
		PTZ00184	527..666	CDD:185504	51/151 (34%)
		EFh	581..631	CDD:298682	19/49 (39%)
		EFh	614..667	CDD:298682	20/53 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	358	1.000	Domainoid score	I921
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	656	1.000	Inparanoid score	I755
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	1	1.000	-	-		mtm6388
orthoMCL	1	0.900	-	-		OOG6_100404
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.870