DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpB and capn5a

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	NP_001073476.1	Gene:	capn5a / 563346	ZFINID:	ZDB-GENE-061103-214	Length:	639	Species:	Danio rerio

Alignment Length:	538	Identity:	209/538 - (38%)
Similarity:	294/538 - (54%)	Gaps:	72/538 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 FTSVKVPENQNMFWMGRKATSARQNSVSKGDFQSLRDSCLANGTMFEDPDFPATNASLMYSRRPD 279
            |:|||..|.|                    :|.:||..|..|.|:||||.|.|.:.||.......
Zfish     2 FSSVKPFEGQ--------------------EFSALRKQCQQNHTLFEDPVFRAEDQSLFLQGNRL 46

  Fly   280 RYYEWLRPGDIADDPQFFVEGYSRFDVQQGELGDCWLLAAAANLTQDSTLFFRVIP--PDQDFQE 342
            ....|.||.|:.:||..||.|.|..|:.||:||:||.:||.::|.....|:.:|||  .||::.:
Zfish    47 GKVTWKRPKDLCEDPHLFVNGISAHDLNQGQLGNCWFVAACSSLASREALWQKVIPDWKDQEWDK 111

  Fly   343 N----YAGIFHFKFWQYGKWVEVVIDDRLPTYNGELIYMHSTEKNEFWSALLEKAYAKLHGSYEA 403
            |    |||||||:||::|.||.|||||||||.||:|||.||.:.|||||||:||||||:.|.|||
Zfish   112 NKPESYAGIFHFRFWRFGDWVGVVIDDRLPTANGKLIYCHSNDSNEFWSALVEKAYAKMCGCYEA 176

  Fly   404 LKGGTTCEAMEDFTGGVTEWYDI--------KEAPPNLFSIMMKAAERGSMMGCSLEPDPHV-LE 459
            |.||.|.:|:.||||||:|..|:        :||...||..::|...||.::.||:...... :|
Zfish   177 LDGGNTADALVDFTGGVSEPMDLLEGKFAQDEEARHQLFDRVLKVHNRGGLISCSIRATTQADME 241

  Fly   460 AETPQGLIRGHAYSITKVCLMDISTP----NRQGKLPMIRMRNPWGNDAEWSGPWSDSSPEWRFI 520
            |....||::||||::|.|..:.:.:.    .:..||.|||||||||... |:|.|||||.||:.:
Zfish   242 ARLDCGLVKGHAYAVTDVRKVRLGSGLLAFFKSEKLSMIRMRNPWGQRG-WNGAWSDSSEEWKRV 305

  Fly   521 PEHTKEEIGLNFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQHSSRRKWEMSMFEGEWTS 585
            .:..:|.:|:..:.||||||.|.||..||..:.:|.|...|..     |..:.||..:..|.|:.
Zfish   306 SKGERERLGVTVEDDGEFWMDFDDFCKHFTDLILCRLINTSYL-----SIHKTWEEEVMRGCWSR 365

  Fly   586 -----GVTAGGCRNFLETFWHNPQYIISLEDPDDEDDDGKCTAIVALMQKNRRSKRNVGIDCLTI 645
                 ...:|||.|...||..||||:..:...:||       .::.|.|:::|::...  :.:.|
Zfish   366 HDDPLRNRSGGCINHKTTFLQNPQYVFDVTKAEDE-------VLICLQQQDKRARAKG--ENMAI 421

  Fly   646 GFAIYHLTDRDMQVKPQGLNFFKYRASVAR---SPHFINTREVCARFKLPPGHYLIVPSTFDPNE 707
            ||.|..:.          ||......|:.:   |..:||:|.|..|..|..|.|:||||||||..
Zfish   422 GFDIQRVE----------LNRIYRMHSIQKSVGSSIYINSRSVFLRKDLKEGRYVIVPSTFDPGM 476

  Fly   708 EGEFIIRVFSETRNNMEE 725
            .|:|::|:|::..::.:|
Zfish   477 PGDFLLRIFTDVPSDCKE 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403	5/9 (56%)
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042	145/314 (46%)
		Calpain_III	574..721	CDD:279416	47/154 (31%)
		EF-hand_7	759..825	CDD:290234
		EFh	761..826	CDD:298682
		FRQ1	827..>908	CDD:227455
capn5a	NP_001073476.1	Peptidase_C2	27..341	CDD:279042	145/314 (46%)
		Calpain_III	354..490	CDD:279416	47/154 (31%)
		C2_Calpain	512..637	CDD:176011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920