Protein Alignment CalpB and capn7

DIOPT Version :10

• Sequence 1: NP_524016.4
• Gene: CalpB / 39165
• FlyBaseID: FBgn0025866
• Length: 925
• Species: Drosophila melanogaster
• Sequence 2: NP_001128580.1
• Gene: capn7 / 556792
• ZFINID: ZDB-GENE-111111-1
• Length: 815
• Species: Danio rerio
• Alignment Length: 751
• Identity: 161/751 - (21%)
• Similarity: 258/751 - (34%)
• Gaps: 292/751 - (38%)

  Fly   149 PAAPLAPYPSAMPGLPGMPMPYAPMPTSPAPQHNIGFPALPYPTA--PPPESAPTQEEEPSV--- 208
            ||:...|..||..| |.....:.|:    .|..:|...|.|...|  ..|:......||..|
Zfish   157 PASQDKPGSSASKG-PAQVRQFFPL----GPDFSIHDKAQPVRAAQSSEPQGQRYTAEEIEVLRK 216

  Fly   209 -----GVAELSFTSV--------KVPENQNMFWMGRKATSARQNSVSKGDFQSLRDSCLANGTMF 260
                 |:..:.|.||        .||.:..   .|:.|.|.:|.::
Zfish   217 TSKVNGIEYVPFMSVDLRERFAFPVPFSDK---CGKLALSPKQRAI------------------- 259

  Fly   261 EDPDFPATNASLMYSRRPDRYYEWLRPGDIADDPQFFVEGYSRFDVQQGELGDCWLLA-----AA 320
                         :||       |:||.||.::|. .:...|.|.::|..:.||..:|     ||
Zfish   260 -------------FSR-------WVRPDDICNNPT-MIFTVSSFSIKQTVVSDCSFVASLAISAA 303

  Fly   321 ANLTQDSTLFFRVIPPDQ---DFQENYAGIFHFKFWQYGKWVEVVIDDRLPT-YNGELIYMHSTE 381
            ........|...:|.|..   :.:.|..|.:..|....|...:|:|||.||. .||||:..:|:.
Zfish   304 YERRYSKKLITSIIYPQNRKGEPEYNPCGKYMVKLHINGVPRKVIIDDFLPVDRNGELLCSYSSN 368

  Fly   382 KNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTG--------GVTEWYDIKEA--------- 429
            :||.|.:|:||||.|:.|.|             ||.|        .:|.|...:.|
Zfish   369 RNELWVSLIEKAYMKVMGGY-------------DFPGSNSNIDLHALTGWIPERIAMHSDNQSFN 420

  Fly   430 PPNLFSIMMKAAERGSMMGCSLEPDPHVLEAETPQ--GLIRGHAYSITKVCLMDISTPNRQGK-L 491
            ..:.|.::.:...||.::   :.....|:..|..:  ||:..|||::     :||    ||.| .
Zfish   421 KDDTFRMLYQRFHRGDVL---ITTATGVMTEEEGERWGLVPTHAYAV-----LDI----RQYKDK 473

  Fly   492 PMIRMRNPWGNDAEWSGPWSDSSPEWRFIPEHTKEEIGLNFD-------RDGEFWMSFQDFLNHF 549
            ..::::|||.: ..|.|.:|:.. |..:.|:..|.   ||||       .:|.||:.::|...::
Zfish   474 RFLQLKNPWSH-LRWKGSYSERD-EKNWTPDLLKY---LNFDPKTAQKFDNGVFWIIWEDLCQYY 533

  Fly   550 DRV-------------------------------------------------------------- 552
            |.:
Zfish   534 DVIYLSWNPALFKESSCIHSSWDGKQGPVKDVYSLANNPQYKLEVQCPQGGAAVWVLLTRHITDK 598

  Fly   553 -------EICNL--------------------------SPDSLTE------------------DQ 566
                   |...|                          ||..||:                  ::
Zfish   599 DDFAQNREFITLVVYKTNGKKVYYPAEPPPYIDGIRINSPHYLTKIKLTSPGTHTFTLVVSQYEK 663

  Fly   567 QHS---SRRKWEMSMF---------------EGEWTSGVTAGGCRNFLETFWHNPQYIISLEDPD 613
            |::   :.|.:.:..|               .|:| .|.:||||.|:.:|:.:||.|.:::|.|.
Zfish   664 QNTINYTLRVYSVCKFNFSKIPTPFTNTKRINGQW-KGASAGGCGNYKDTYKNNPIYQLNMEKPG 727

  Fly   614 DEDDDGKCTAIVALMQKNRRSKR-NVGIDCLTIGFAIYHLTDRDMQVKPQGLNFFKYRASVARSP 677
                        .|:.:.|.|:: :||.:.:|:.      |..|     .|.:.|:.|||.....
Zfish   728 ------------PLLIELRGSRQYSVGFEVVTVS------TTGD-----SGSSGFQKRASGDYRC 769

  Fly   678 HFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFII 713
            .|. ..||   ..||.|.|.::|:||.|.:||.|.:
Zfish   770 GFC-YMEV---ESLPAGIYNVIPTTFLPKQEGPFFL 801

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_524016.4	PHA03247	<40..207	CDD:223021	16/59 (27%)
		Peptidase_C2	260..556	CDD:459889	85/400 (21%)
		Calpain_III	579..716	CDD:460050	42/151 (28%)
		EFh_PEF_CalpA_B	758..925	CDD:320071
		EF-hand motif	758..786	CDD:320071
		EF-hand motif	799..829	CDD:320071
		EF-hand motif	830..860	CDD:320071
		EF-hand motif	866..894	CDD:320071
		EF-hand motif	895..925	CDD:320071
capn7	NP_001128580.1	MIT	5..76	CDD:469712
		MIT	85..159	CDD:469712	1/1 (100%)
		CysPc	216..540	CDD:238004	94/396 (24%)
		calpain_III	689..812	CDD:214786	41/141 (29%)