DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpB and capn1

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	NP_001013632.1	Gene:	capn1 / 541455	XenbaseID:	XB-GENE-990196	Length:	713	Species:	Xenopus tropicalis

Alignment Length:	698	Identity:	315/698 - (45%)
Similarity:	443/698 - (63%)	Gaps:	42/698 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 DFQSLRDSCLANGTMFEDPDFPATNASLMYSR---RPDRYY--EWLRPGDIADDPQFFVEGYSRF 304
            |:..:...||.|.|:|:|..||.:..||.:..   ...:.|  :|:||..:..:|||.|:|.:|.
Frog    41 DYDRILHECLQNRTLFKDDTFPPSAYSLGFKELGPNSSKTYGVKWVRPSQLVSNPQFIVDGATRT 105

  Fly   305 DVQQGELGDCWLLAAAANLTQDSTLFFRVIPPDQDFQENYAGIFHFKFWQYGKWVEVVIDDRLPT 369
            |:.||.|||||||||.|:||.:.|:..||:|..|.||:||||:|||:.||:|:||:|||||.||.
Frog   106 DICQGALGDCWLLAAIASLTLNDTILHRVVPHGQSFQDNYAGVFHFQLWQFGEWVDVVIDDYLPV 170

  Fly   370 YNGELIYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGGVTEWYDIKEAPPNLF 434
            .:|:|:::||...||||||||||||||.:|.||||.||:|.|..|||||||||||::|:||.:||
Frog   171 KDGKLVFVHSASGNEFWSALLEKAYAKANGCYEALSGGSTSEGFEDFTGGVTEWYEMKKAPKDLF 235

  Fly   435 SIMMKAAERGSMMGCSLE-PDPHVLEAETPQGLIRGHAYSITKVCLMDISTPNRQGKLPMIRMRN 498
            ||:|||.||||:||||:: .....:||.|.:.|::|||||:|..  .:|:...|..||  |||||
Frog   236 SIIMKAVERGSLMGCSIDITSATDMEAVTFKKLVKGHAYSVTGA--KEINFRGRSQKL--IRMRN 296

  Fly   499 PWGNDAEWSGPWSDSSPEWRFIPEHTKEEIGLNFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLT 563
            ||| :.||:|.|||:|.||..:.....:::.:..: ||||||:|:|||..|.|:|||||:||:||
Frog   297 PWG-EVEWTGAWSDNSSEWNSVDAADSQDLRIKME-DGEFWMAFEDFLREFSRLEICNLTPDALT 359

  Fly   564 EDQQHSSRRKWEMSMFEGEWTSGVTAGGCRNFLETFWHNPQYIISLEDPDDEDDDGK---CTAIV 625
            ..:.    |||..::|.|.|..|.||||||||..|||.|||:.|.|::.||:||.|.   ||.::
Frog   360 ARKY----RKWNTTVFNGNWRKGSTAGGCRNFPATFWINPQFKIKLDEEDDDDDFGSEKGCTFLL 420

  Fly   626 ALMQKNRRSKRNVGIDCLTIGFAIYHLTDR-----DMQVKPQGLNFFKYRASVARSPHFINTREV 685
            |||||::|.:|..|.|..|||||:|.:..:     .:.:|   .:||...||.|||..|||.|||
Frog   421 ALMQKDKRKERRFGKDMETIGFAVYEVPSQFHGQSGVHLK---RDFFLQNASRARSEQFINLREV 482

  Fly   686 CARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETRNNMEENDDEVGFGETDDRIAPSLPPPTPKE 750
            ..|.|||||.|::|||||:||.||:|::|.|||.::         |..|.||.::..|||.....
Frog   483 STRHKLPPGEYIVVPSTFEPNVEGDFVVRFFSENKH---------GSVEMDDPLSADLPPEEVLS 538

  Fly   751 EDDPQRIALRRLFDSVAGSDEEVDWQELKRILDHSM---RDVMVGSDGFSKDAVRSMVAMLDKDR 812
            |.:..: ..:.||..:||:|.|:...||:.||:..|   :|:.  :.|||.::.||||.::|||.
Frog   539 EAEIDQ-GFKNLFKQLAGADNEISATELQSILNKIMSKHKDLR--TSGFSLESCRSMVNLMDKDG 600

  Fly   813 SGRLGFEEFEALLTDIAKWRAVFKLYDTRRTGSIDGFHLRGALNSAGYHLNNRLLNALAHRYGSR 877
            :|:||..||..|...|..:..||:.:|..::||:..:.:|.|:.|||:.|.|.|...:..||...
Frog   601 NGKLGLVEFNVLWNKIKNYLTVFRKFDMDKSGSMSAYEMRLAVESAGFKLTNSLHQLIITRYSEP 665

  Fly   878 EGQIPFDDFLMCAIKVRTFIEMFRERDTDNSDTAFFNLDDWLERTIYS 925
            :..:.||.|..|.|::.|....|:..||:......|::..||:.|:::
Frog   666 DMAVNFDSFTCCLIRLETMFRFFQGMDTEKKGVIHFDIFKWLQMTMFA 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042	158/301 (52%)
		Calpain_III	574..721	CDD:279416	78/154 (51%)
		EF-hand_7	759..825	CDD:290234	27/68 (40%)
		EFh	761..826	CDD:298682	28/67 (42%)
		FRQ1	827..>908	CDD:227455	25/80 (31%)
capn1	NP_001013632.1	Peptidase_C2	56..352	CDD:366222	158/301 (52%)
		Calpain_III	373..518	CDD:366446	76/147 (52%)
		EFh_PEF_CAPN1	545..713	CDD:320073	57/169 (34%)
		EF-hand motif	545..573	CDD:320073	10/27 (37%)
		EF-hand motif	588..617	CDD:320073	13/28 (46%)
		EF-hand motif	618..648	CDD:320073	9/29 (31%)
		EF-hand motif	654..682	CDD:320073	8/27 (30%)
		EF-hand motif	684..713	CDD:320073	7/28 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	361	1.000	Domainoid score	I950
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	643	1.000	Inparanoid score	I801
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	1	1.000	-	-		mtm9483
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060