Protein Alignment CalpB and capn11

DIOPT Version :10

• Sequence 1: NP_524016.4
• Gene: CalpB / 39165
• FlyBaseID: FBgn0025866
• Length: 925
• Species: Drosophila melanogaster
• Sequence 2: XP_031757539.1
• Gene: capn11 / 541454
• XenbaseID: XB-GENE-940593
• Length: 713
• Species: Xenopus tropicalis
• Alignment Length: 689
• Identity: 314/689 - (45%)
• Similarity: 444/689 - (64%)
• Gaps: 42/689 - (6%)

  Fly   245 DFQSLRDSCLANGTMFEDPDFPATNASLMYSR-----RPDRYYEWLRPGDIADDPQFFVEGYSRF 304
            |::||:..|..:|::||||:||...:||.:..     ...:..:|.||.||||||||.|.|.:|.
 Frog    34 DYESLKQQCRESGSLFEDPNFPPIGSSLGFKELGPGTSKTKGVQWKRPHDIADDPQFIVGGATRT 98

  Fly   305 DVQQGELGDCWLLAAAANLTQDSTLFFRVIPPDQDFQENYAGIFHFKFWQYGKWVEVVIDDRLPT 369
            |:.||.|||||||||..:||.:..|..||:|..|.||::|||||||:.||:|:||:||||||||.
 Frog    99 DICQGALGDCWLLAAIGSLTLNEDLLHRVVPHGQGFQDDYAGIFHFQIWQFGEWVDVVIDDRLPV 163

  Fly   370 YNGELIYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGGVTEWYDIKEAPPNLF 434
            .:|||:::||.|.:||||||||||||||:||||||.||:|.|..|||||||.|.|::::||.||.
 Frog   164 KDGELVFVHSAECSEFWSALLEKAYAKLNGSYEALSGGSTTEGFEDFTGGVAEMYELRKAPRNLD 228

  Fly   435 SIMMKAAERGSMMGCSLE-PDPHVLEAETPQGLIRGHAYSITKVCLMDISTPNRQGKLPMIRMRN 498
            .|:.:|.:|||::|||:: .....:||.|.:.|::|||||:|  .|.:::......||  ||:||
 Frog   229 KIIKRALDRGSLLGCSIDITSAFDMEAVTFKKLVKGHAYSVT--ALREVNYMGGVEKL--IRIRN 289

  Fly   499 PWGNDAEWSGPWSDSSPEWRFIPEHTKEEIGLNFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLT 563
            ||| ..||:|.|||:|.||..:....:|::.|..: |||||||||:||..|.|:|||||:||:|.
 Frog   290 PWG-QVEWTGAWSDNSSEWNEVDPSEQEDLQLKME-DGEFWMSFQEFLRQFSRLEICNLTPDALD 352

  Fly   564 EDQQHSSRRKWEMSMFEGEWTSGVTAGGCRNFLETFWHNPQYIISLEDPDDEDDDGK--CTAIVA 626
            :|.|    .||..::::|.|..|.|||||||...|||.|||:.::|.:.||:.||.:  |:.:||
 Frog   353 KDGQ----SKWHSTLYDGTWRRGSTAGGCRNNPATFWINPQFKVTLLEEDDDPDDNELACSFLVA 413

  Fly   627 LMQKNRRSKRNVGIDCLTIGFAIYHLTD-----RDMQVKPQGLNFFKYRASVARSPHFINTREVC 686
            |||||||.:|.||.|..|||||:|.:.|     :::.:|.   :||....|.|||..|||.|||.
 Frog   414 LMQKNRRKERKVGQDMHTIGFAVYEVPDEFRGCQNVHLKK---DFFLRHQSCARSETFINLREVS 475

  Fly   687 ARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETRNNMEENDDEVGFGETDDRIAPSLPPPTPKEE 751
            .:.:||||.|:||||||:|::|.:|::|:|:|..::::|.|:||         :..||......|
 Frog   476 TQIRLPPGEYIIVPSTFEPHKEADFVLRIFTEKHSDIQELDEEV---------SADLPEEEELTE 531

  Fly   752 DDPQRIALRRLFDSVAGSDEEVDWQELKRILDHSM---RDVMVGSDGFSKDAVRSMVAMLDKDRS 813
            ||... :.:.:|..:||.|.|:...|||.||:..:   :|:.  :|||..:|.|.||.::|||.|
 Frog   532 DDVDD-SFKAMFRQLAGEDMEISVFELKTILNRVVAKHKDLK--TDGFGMEACRQMVNLMDKDGS 593

  Fly   814 GRLGFEEFEALLTDIAKWRAVFKLYDTRRTGSIDGFHLRGALNSAGYHLNNRLLNALAHRYGSRE 878
            |:||..||:.|...|.:|...|:.:|..::|:|..:.||.||...||.|||:|:..|..||...:
 Frog   594 GKLGVVEFQILWNKIRQWLTAFRQHDLDKSGTISAYELRIALEGTGYKLNNKLIQVLVARYADSD 658

  Fly   879 GQIPFDDFLMCAIKVRTFIEMFRERDTDNSDTAFFNLDD 917
            ..|.||:|:.|.:|:......|:..| ....||..:|.:
 Frog   659 MGIDFDNFVCCLVKLEAMFRFFKALD-QGEGTAEMSLGE 696

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_524016.4	PHA03247	<40..207	CDD:223021
		Peptidase_C2	260..556	CDD:459889	160/301 (53%)
		Calpain_III	579..716	CDD:460050	70/143 (49%)
		EFh_PEF_CalpA_B	758..925	CDD:320071	58/163 (36%)
		EF-hand motif	758..786	CDD:320071	10/27 (37%)
		EF-hand motif	799..829	CDD:320071	14/29 (48%)
		EF-hand motif	830..860	CDD:320071	9/29 (31%)
		EF-hand motif	866..894	CDD:320071	10/27 (37%)
		EF-hand motif	895..925	CDD:320071	5/23 (22%)
capn11	XP_031757539.1	Peptidase_C2	49..345	CDD:459889	160/301 (53%)
		Calpain_III	358..515	CDD:238132	74/159 (47%)
		EFh_PEF	537..696	CDD:355382	58/161 (36%)
		EF-hand motif	537..565	CDD:320054	10/27 (37%)
		EF-hand motif	580..609	CDD:320054	14/28 (50%)
		EF-hand motif	610..639	CDD:320054	9/28 (32%)
		EF-hand motif	646..674	CDD:320054	10/27 (37%)