DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpB and capn13

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	NP_001008025.1	Gene:	capn13 / 493387	XenbaseID:	XB-GENE-6045506	Length:	763	Species:	Xenopus tropicalis

Alignment Length:	793	Identity:	255/793 - (32%)
Similarity:	394/793 - (49%)	Gaps:	114/793 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 PSVGVAELSFTSVKVPENQNMFWMGRKATSARQNSVSKGDFQSLRDSCLANGTMFEDPDFPATNA 270
            |..||.:      |:.|.|..  ..|..|..........||.|:|:||.:...:|||..|||:.:
Frog     2 PMPGVYQ------KIAEGQQA--KTRIGTVGNPKKFKGQDFDSIRESCYSRRQLFEDETFPASVS 58

  Fly   271 SLMYSRRP-DRY--YEWLRPGDIADDPQFFVEGYSRFDVQQGELGDCWLLAAAANLTQDSTLFFR 332
            |:.....| |:.  .:|.||.:|..|.:..|:|.|.||:.||.|||||:|||...||........
Frog    59 SIGQKLLPKDQLLSIKWERPKEIQSDARLLVDGASIFDMVQGYLGDCWVLAAVGALTLHQKFLDI 123

  Fly   333 VIPPDQDFQENYAGIFHFKFWQYGKWVEVVIDDRLPTYNGELIYMHSTEKNEFWSALLEKAYAKL 397
            |||.||:|...|||.|||:|||:|:||:|||||||||.||:.:.:|....||||..|||||||||
Frog   124 VIPKDQEFNYKYAGAFHFRFWQFGEWVDVVIDDRLPTLNGKYLSVHPRSDNEFWPTLLEKAYAKL 188

  Fly   398 HGSYEALKGGTTCEAMEDFTGGVTEWYDIKEAPPNLFSIMMKAAERGSMMGCSLEPDPHVLEAET 462
            .|||:.|..|...||:.||:|||...:|:.:.|.:|..|::.||:.||:||.:..........|.
Frog   189 RGSYQNLHWGYISEALVDFSGGVLVEFDLTKPPQDLRDIVIAAAKSGSLMGSNTPGGKQSGNPEL 253

  Fly   463 PQGLIRGHAYSITKVCLMDISTPNRQGKLPMIRMRNPWGNDAEWSGPWSDSSPEWRFIPEHTKEE 527
            ..||::||||::|....::.    :.|...::|:.||||. .||:|.|||::|:|..:....:::
Frog   254 QNGLVQGHAYTVTDATQVEY----KNGTEDLVRVWNPWGK-GEWNGRWSDNAPQWDRVRADVRQK 313

  Fly   528 IGLNFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQHSSRRKWEMSMFEGEWTSGVTAGGC 592
            :.:. ..|||||||.||||.:|....|||.:|.....|   :.:|.|:...:...|..|.||.||
Frog   314 LNVQ-KNDGEFWMSCQDFLQNFSCASICNHTPAYFDFD---NPKRTWQTLTYFSRWVRGSTAAGC 374

  Fly   593 RNFLETFWHNPQYIISLEDPDDEDDDGKCTAIVALMQ----KNRRSKRNVGIDCLTIGFAIYHLT 653
            .: .|..|.|||::||:.|.:........|  |||||    :::.|:|.:|     ||||:..:.
Frog   375 SS-KEDLWRNPQFVISVSDSEGMKRGYNVT--VALMQSLENEHKYSQRWMG-----IGFALCRVA 431

  Fly   654 DRDMQVKPQGLNFFKYRASVARSPHFINT-----REVCARFKLPPGHYLIVPSTFDPNEEGEFII 713
              .|.||  |::...|.|..|..  .|||     |||...|..|||.|:::|.|....:|.||::
Frog   432 --SMGVK--GISQQNYSAKQAMD--VINTEIQISREVTRSFMAPPGTYVVIPFTESKGQESEFLL 490

  Fly   714 RVFSETRNNMEENDDEVGFGETDDRIAPSL-------PPPTPKEEDDPQ---------------- 755
            |:|.:|:...:..|.:....|.:....||.       |.|.|::::.|.
Frog   491 RIFLKTKEIDKFQDTKTVPREGNQTFYPSNGGSRYQDPKPKPRDDNQPMYPNETRARNQSSSSLP 555

  Fly   756 ----------------------------RIALRR--------LFDSVAGSDEEVDWQELKRILDH 784
                                        :..|::        :|........|:..::|:|:|:
Frog   556 REESPYQYGSDGGLSDFSSSLSMNSQIPKAVLKKYQDDNYEMVFTRYCNKSSELYAEQLQRLLN- 619

  Fly   785 SMRDVMV-------GSDGFSKDAVRSMVAMLDKDRSGRLGFEEFEALLTDIAKWRAVFKLYDTRR 842
               :|::       |...|:.||.|.::.::|.:.:|||..:||..|...:...:.:|:..|..:
Frog   620 ---EVIIKDQTFAGGRGDFTLDACRGILMLMDLNANGRLSLQEFGRLWKRLNMCKDMFRSIDGNQ 681

  Fly   843 TGSIDGFHLRGALNSAGYHLNNRLLNALAHRYGSREGQIPFDDFLMCAIKVRTFIEMFRERDTDN 907
            ||.||...|:.|:..||..::|.|:|.:..||.:...::.|.||:.|.|::.|..::|:....|.
Frog   682 TGFIDASGLKKAVQLAGLPISNALINVMVLRYANSSEKLSFADFVCCMIRLETVTKVFKNLSKDG 746

  Fly   908 SDTAFFNLDDWLE 920
            .. .:.:.::|::
Frog   747 RG-VYLSGEEWMQ 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403	5/18 (28%)
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042	131/298 (44%)
		Calpain_III	574..721	CDD:279416	54/155 (35%)
		EF-hand_7	759..825	CDD:290234	18/80 (23%)
		EFh	761..826	CDD:298682	18/79 (23%)
		FRQ1	827..>908	CDD:227455	23/80 (29%)
capn13	NP_001008025.1	Peptidase_C2	48..341	CDD:366222	131/298 (44%)
		Calpain_III	364..497	CDD:366446	52/146 (36%)
		EFh_PEF_CAPN13_14	595..763	CDD:320070	42/169 (25%)
		EF-hand motif	595..622	CDD:320070	5/30 (17%)
		EF-hand motif	639..668	CDD:320070	9/28 (32%)
		EF-hand motif	669..699	CDD:320070	9/29 (31%)
		EF-hand motif	705..733	CDD:320070	9/27 (33%)
		EF-hand motif	735..763	CDD:320070	3/25 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020