Protein Alignment CalpB and capn2

DIOPT Version :10

• Sequence 1: NP_524016.4
• Gene: CalpB / 39165
• FlyBaseID: FBgn0025866
• Length: 925
• Species: Drosophila melanogaster
• Sequence 2: XP_031757476.1
• Gene: capn2 / 448035
• XenbaseID: XB-GENE-993758
• Length: 703
• Species: Xenopus tropicalis
• Alignment Length: 717
• Identity: 317/717 - (44%)
• Similarity: 454/717 - (63%)
• Gaps: 52/717 - (7%)

  Fly   236 ARQNSVSKG-------------DFQSLRDSCLANGTMFEDPDFPATNASLMYSRRPDRYYE---- 283
            |::.:::.|             |:::||:.||.:||:|:|..|||.::||.:........:
 Frog     9 AKERALASGLGTNEKALPYLSQDYEALRNECLQSGTLFKDLSFPAIHSSLGFKELGQHSAKCQGV 73

  Fly   284 -WLRPGDIADDPQFFVEGYSRFDVQQGELGDCWLLAAAANLTQDSTLFFRVIPPDQDFQENYAGI 347
             |.||.|:..||||...|.:|.|:.||.|||||||||.|:||.:..:..||:|.||.||||||||
 Frog    74 VWKRPKDLCPDPQFIAGGATRTDICQGALGDCWLLAAIASLTLNEQILSRVVPKDQSFQENYAGI 138

  Fly   348 FHFKFWQYGKWVEVVIDDRLPTYNGELIYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGTTCEA 412
            |||:|||||:||:|||||||||.:|:|:::||.|.:||||||:|||||||:||||||.||||.|.
 Frog   139 FHFQFWQYGEWVDVVIDDRLPTKDGKLLFVHSAEGSEFWSALMEKAYAKLNGSYEALSGGTTTEG 203

  Fly   413 MEDFTGGVTEWYDIKEAPPNLFSIMMKAAERGSMMGCSLE-PDPHVLEAETPQGLIRGHAYSITK 476
            .||||||:.|||::::||||||.|:.||...||::|||:: ......||.|.|.|::|||||:|.
 Frog   204 FEDFTGGLAEWYELRKAPPNLFKIIQKALRTGSLLGCSIDITSAAETEAITFQKLVKGHAYSVTA 268

  Fly   477 VCLMDISTPNRQGKL-PMIRMRNPWGNDAEWSGPWSDSSPEWRFIPEHTKEEIGLNFDRDGEFWM 540
            .     .....:|.| .:||:||||| :.||:|.|||:|.||..:....:|::....| ||||||
 Frog   269 A-----EEVQYRGNLEKLIRIRNPWG-EVEWTGAWSDNSSEWNSVDPDVREKLIKRCD-DGEFWM 326

  Fly   541 SFQDFLNHFDRVEICNLSPDSLTEDQQHSSRRKWEMSMFEGEWTSGVTAGGCRNFLETFWHNPQY 605
            ||.|||.::.|:|||||:||:|..|:.    .||.::..:|.|..|.||||||||.||||.||||
 Frog   327 SFNDFLRNYSRLEICNLTPDTLASDKY----SKWSLTKMDGTWRRGSTAGGCRNFPETFWMNPQY 387

  Fly   606 IISLEDPDDEDDDGK--CTAIVALMQKNRRSKRNVGIDCLTIGFAIYHLT-----DRDMQVKPQG 663
            :|.||:.||:.||.:  ||.||.|:|||||.:|.:|.|..|||||||.:.     .:|:::....
 Frog   388 VIKLEEADDDPDDNEEGCTFIVGLIQKNRRKQRKMGEDMHTIGFAIYEVPPQLTGQKDIRLSRDY 452

  Fly   664 LNFFKYRASVARSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETRNNMEENDD 728
            :...|.|   .:|..:||.|||..||:||||.|:|:||||:|::.|:|.:||||| :|...:..|
 Frog   453 ILRNKIR---EKSDTYINLREVLNRFRLPPGEYVILPSTFEPHKVGDFCLRVFSE-KNAESKCQD 513

  Fly   729 EVGFGETDDRIAPSLPPPTPKEEDDPQRIALRRLFDSVAGSDEEVDWQELKRILDH--SMRDVMV 791
            .|    .||.|...:.....::..||.   .:|:|.::||.|:|:...||..||..  |.|: .:
 Frog   514 RV----PDDEIKADIDEDVNEDAIDPN---FKRMFLALAGDDKEISPHELFNILQKVISKRE-DI 570

  Fly   792 GSDGFSKDAVRSMVAMLDKDRSGRLGFEEFEALLTDIAKWRAVFKLYDTRRTGSIDGFHLRGALN 856
            .|||||.:..|::|.:||.|.:|:||.:||:.|.|.|.|::.::...|...:|:|:.:.:||||.
 Frog   571 KSDGFSIETCRTIVDLLDSDGTGKLGLKEFKILWTKILKYQKIYSSVDRDHSGTINSYEMRGALE 635

  Fly   857 SAGYHLNNRLLNALAHRYGSREGQIPFDDFLMCAIKVRTFIEMFRERDTDNSDTAFFNLDDWLER 921
            :||..:|:.:...|..|:...:..|.||:|:.|.:::....::|.:.||:.:......:|.||..
 Frog   636 AAGIKVNSTINELLVARFADEDHTIDFDNFVRCLLRLEIMFKIFNQMDTEKTGVVTLKMDTWLSL 700

  Fly   922 TI 923
            |:
 Frog   701 TV 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_524016.4	PHA03247	<40..207	CDD:223021
		Peptidase_C2	260..556	CDD:459889	161/302 (53%)
		Calpain_III	579..716	CDD:460050	71/143 (50%)
		EFh_PEF_CalpA_B	758..925	CDD:320071	55/168 (33%)
		EF-hand motif	758..786	CDD:320071	10/29 (34%)
		EF-hand motif	799..829	CDD:320071	12/29 (41%)
		EF-hand motif	830..860	CDD:320071	9/29 (31%)
		EF-hand motif	866..894	CDD:320071	7/27 (26%)
		EF-hand motif	895..925	CDD:320071	7/29 (24%)
capn2	XP_031757476.1	Peptidase_C2	46..342	CDD:459889	161/302 (53%)
		Calpain_III	361..502	CDD:460050	71/143 (50%)
		EFh_PEF	537..703	CDD:355382	55/167 (33%)
		EF-hand motif	537..564	CDD:320054	10/26 (38%)
		EF-hand motif	579..608	CDD:320054	12/28 (43%)
		EF-hand motif	609..638	CDD:320054	8/28 (29%)
		EF-hand motif	645..673	CDD:320054	7/27 (26%)
		EF-hand motif	675..703	CDD:320054	7/28 (25%)