DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpB and capn9

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	NP_001003501.1	Gene:	capn9 / 445107	ZFINID:	ZDB-GENE-010724-2	Length:	688	Species:	Danio rerio

Alignment Length:	711	Identity:	331/711 - (46%)
Similarity:	455/711 - (63%)	Gaps:	32/711 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 SVKVPENQNMFWMGRKATSARQNSVSKG-DFQSLRDSCLANGTMFEDPDFPATNASLMYSRRPDR 280
            ||.:|.:...       |:..:::.:.| .::.||..||..|.:||||||||.:.||.||:|...
Zfish     4 SVTLPGSSGQ-------TAVVESTQADGKTYEQLRRECLQKGKLFEDPDFPAVDGSLFYSQRVPV 61

  Fly   281 YYEWLRPGDIADDPQFFVEGYSRFDVQQGELGDCWLLAAAANLTQDSTLFFRVIPPDQDFQENYA 345
            .:||.|||:|..:|||...|.:|.|:.||:|||||||||.|:||.......||:|.||.|...||
Zfish    62 NFEWKRPGEICKEPQFITGGATRTDICQGQLGDCWLLAAIASLTLKEETLNRVVPNDQTFDRGYA 126

  Fly   346 GIFHFKFWQYGKWVEVVIDDRLPTYNGELIYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGTTC 410
            |||||:|||:.||::||:|||||....:|:::||.:.|||||||||||||||:|||||||||:|.
Zfish   127 GIFHFQFWQHNKWMDVVVDDRLPCVRDKLVFLHSADNNEFWSALLEKAYAKLNGSYEALKGGSTM 191

  Fly   411 EAMEDFTGGVTEWYDIKEAPPNLFSIMMKAAERGSMMGCSLE-PDPHVLEAETPQGLIRGHAYSI 474
            ||||||||||.|.|:.|..|.|||.|:.||.|||||:|||:: ......||:|..||::|||||:
Zfish   192 EAMEDFTGGVGEMYETKNGPSNLFLILKKAIERGSMLGCSIDITSSAESEAQTSTGLVKGHAYSV 256

  Fly   475 TKVCLMDISTPNRQG-KLPMIRMRNPWGNDAEWSGPWSDSSPEWRFIPEHTKEEIGLNFDRDGEF 538
            |     .:...|.:| |:.:||:||||| ..||:|||||:|.||..|....|:.:..|...||||
Zfish   257 T-----GVEEVNYRGAKVQLIRVRNPWG-QVEWNGPWSDNSREWTVIDSSEKKRLLQNSLDDGEF 315

  Fly   539 WMSFQDFLNHFDRVEICNLSPDSLTEDQQHSSRRKWEMSMFEGEWTSGVTAGGCRNFLETFWHNP 603
            ||.|.||.:::|:|||||||||:|::|..    ::|.:::|||.|..|.|||||||:::|||.||
Zfish   316 WMEFGDFKSNYDKVEICNLSPDALSDDVS----KQWAVNLFEGSWIRGSTAGGCRNYIDTFWTNP 376

  Fly   604 QYIISLEDPDDEDDDGKCTAIVALMQKNRRSKRNVGIDCLTIGFAIYHLTDRDMQVKPQGLNFFK 668
            |:.:.||:||  |.|..|:.||||||||||..|..|:|..|||||||...|   ....||.:||:
Zfish   377 QFKLHLENPD--DGDKLCSVIVALMQKNRRRLRKEGLDLETIGFAIYEAPD---DQDHQGKDFFR 436

  Fly   669 YRASVARSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETRNNMEENDDEVGFG 733
            |..|.|||..:||.|||..||:||||:||:||:||.|::|.:|:||:|||.:....|..:::
Zfish   437 YNPSKARSRTYINVREVSERFRLPPGNYLLVPTTFQPHKEADFLIRLFSEKKAGAIEVGNKI--- 498

  Fly   734 ETDDRIAPSLPPPTPKEEDDPQRIALRRLFDSVAGSDEEVDWQELKRILDHSM-RDVMVGSDGFS 797
            |.|   .|..|.|.|.||:..:...||:||:.|||.|..:..:||:.:|::.: |...|..||.|
Zfish   499 EAD---LPEPPKPNPPEEETDEEKGLRKLFEQVAGPDNVISARELQHVLNNVLGRRKEVKFDGLS 560

  Fly   798 KDAVRSMVAMLDKDRSGRLGFEEFEALLTDIAKWRAVFKLYDTRRTGSIDGFHLRGALNSAGYHL 862
            .:...|::.::|.|.||.:.|.||:.....:.||..:|..||..|:|::..:.||.|||:||..|
Zfish   561 LNTCISIINLMDVDGSGMMEFSEFKVFWDKLKKWIMLFLSYDVDRSGTMSSYELRSALNAAGMKL 625

  Fly   863 NNRLLNALAHRYGSREGQIPFDDFLMCAIKVRTFIEMFRERDTDNSDTAFFNLDDWLERTI 923
            |||:|..|..|:...:.:|.|||:|.|.:::.....:|:..|.........|:..:|..|:
Zfish   626 NNRILQLLGLRFADEKLEIDFDDYLTCIVRLENMFRIFQALDAQKKGEVSLNMHQFLLLTM 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403	3/7 (43%)
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042	167/297 (56%)
		Calpain_III	574..721	CDD:279416	81/146 (55%)
		EF-hand_7	759..825	CDD:290234	24/66 (36%)
		EFh	761..826	CDD:298682	22/65 (34%)
		FRQ1	827..>908	CDD:227455	29/80 (36%)
capn9	NP_001003501.1	Peptidase_C2	41..333	CDD:279042	167/297 (56%)
		Calpain_III	347..489	CDD:279416	81/146 (55%)
		EFh	564..618	CDD:298682	17/53 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	358	1.000	Domainoid score	I921
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38208
Inparanoid	1	1.050	656	1.000	Inparanoid score	I755
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	1	1.000	-	-		mtm6388
orthoMCL	1	0.900	-	-		OOG6_100404
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.870