DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpB and capn2l

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	NP_001003485.1	Gene:	capn2l / 445091	ZFINID:	ZDB-GENE-050417-341	Length:	700	Species:	Danio rerio

Alignment Length:	707	Identity:	318/707 - (44%)
Similarity:	441/707 - (62%)	Gaps:	52/707 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 TSARQNSVSKGDFQSLRDSCLANGTMFEDPDFPATNASLMYSR-RPD----RYYEWLRPGDIADD 293
            |:|:.......|:::|:..||.:|.:|.|..|.|..::|.:.. .|:    |..|||||..:..:
Zfish    20 TNAQAVKFLNQDYEALKRECLESGRLFHDDMFEANVSALGFKELGPNSSKVRGVEWLRPKQLTSN 84

  Fly   294 PQFFVEGYSRFDVQQGELGDCWLLAAAANLTQDSTLFFRVIPPDQDFQENYAGIFHFKFWQYGKW 358
            |.|...|.:|.|:.||.|||||||||.|:||.:..:|.||:|..|.|..:|||||||:|||:|:|
Zfish    85 PTFISGGATRTDICQGALGDCWLLAAIASLTLNQDVFARVVPAGQSFDGDYAGIFHFQFWQFGEW 149

  Fly   359 VEVVIDDRLPTYNGELIYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGGVTEW 423
            |:||||||||..||||:::||.|.:||||||||||||||:|.||||.||||.|..||||||:.|.
Zfish   150 VDVVIDDRLPARNGELLFVHSAEGSEFWSALLEKAYAKLNGCYEALSGGTTTEGFEDFTGGIAEV 214

  Fly   424 YDIKEAPPNLFSIMMKAAERGSMMGCSLE-PDPHVLEAETPQGLIRGHAYSITKVCLMDISTPNR 487
            :::.:|.||||..:.||...||::|||:: ......||.|.|.|::|||||:|     .......
Zfish   215 HELAKAGPNLFKTIQKALSWGSLLGCSIDITSSSDSEAITSQKLVKGHAYSVT-----GAEEVEY 274

  Fly   488 QGKL-PMIRMRNPWGNDAEWSGPWSDSSPEWRFIPEHTKEEIGLNFDRDGEFWMSFQDFLNHFDR 551
            :|.| .:||:||||| ..||:|||||.|.|||.|.::.:|.:....: ||||||||.||:.|:.|
Zfish   275 RGDLTKLIRIRNPWG-QVEWTGPWSDGSSEWRQISDNDRERLSSKAE-DGEFWMSFSDFMRHYSR 337

  Fly   552 VEICNLSPDSLTEDQQHSSRRKWEMSMFEGEWTSGVTAGGCRNFLETFWHNPQYIISLEDPDDE- 615
            ||||||:||:||::    |..||.:|.|:|.|.:|.|||||||:..:||.|||::|.||:.||:
Zfish   338 VEICNLTPDALTDE----SVNKWALSKFDGNWRNGSTAGGCRNYPNSFWMNPQFLIKLEEQDDDP 398

  Fly   616 -DDDGKCTAIVALMQKNRRSKRNVGIDCLTIGFAIYHLTDRDMQVKPQGL--NFFKYRASVARSP 677
             |::..|:.:|.|:|||||..|.||.|..|||||||.:.|:.:..:...|  |||...||.|||.
Zfish   399 TDNEAGCSFVVGLIQKNRRKMRKVGEDMNTIGFAIYEVPDQFVGQRNVHLDRNFFVRHASAARSE 463

  Fly   678 HFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETRNNMEENDD---------EVGFG 733
            .|||.||||:||.||||.||||||||:||::|:|.:|||||.:...:|.||         |:..|
Zfish   464 TFINLREVCSRFCLPPGEYLIVPSTFEPNKDGDFCVRVFSEKQAEFQELDDPVESKVAEIEITEG 528

  Fly   734 ETDDRIAPSLPPPTPKEEDDPQRIALRRLFDSVAGSDEEVDWQELKRILDHSM-RDVMVGSDGFS 797
            :.|.|                    .::||..:||:|.|:...||::||::.: :...:.:||||
Zfish   529 DIDSR--------------------FKKLFGQLAGADCEISAFELQKILNNVIAKRKEIKTDGFS 573

  Fly   798 KDAVRSMVAMLDKDRSGRLGFEEFEALLTDIAKWRAVFKLYDTRRTGSIDGFHLRGALNSAGYHL 862
            .:..|:||.:||||.:|:||..||:.|.|.|..:..|:...|..::|::....:|.|:..||:.|
Zfish   574 LETCRNMVNLLDKDGTGKLGLLEFKILWTKIELFVDVYSKNDKDQSGTMSSMEMREAVEKAGFSL 638

  Fly   863 NNRLLNALAHRYGSREGQIPFDDFLMCAIKVRTFIEMFRERDTDNSDTAFFNLDDWL 919
            ||.|...|..||......|.||:|:.|.|::....:.|:..|.|.:.|...|:.:||
Zfish   639 NNALHQILVARYSESNLTIDFDNFVACLIRLECMFKAFKVLDKDKNGTVELNMIEWL 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042	156/302 (52%)
		Calpain_III	574..721	CDD:279416	83/150 (55%)
		EF-hand_7	759..825	CDD:290234	26/66 (39%)
		EFh	761..826	CDD:298682	27/65 (42%)
		FRQ1	827..>908	CDD:227455	24/80 (30%)
capn2l	NP_001003485.1	Peptidase_C2	46..342	CDD:279042	156/302 (52%)
		Calpain_III	356..507	CDD:279416	83/150 (55%)
		EFh	577..631	CDD:298682	19/53 (36%)
		FRQ1	604..>695	CDD:227455	26/90 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	358	1.000	Domainoid score	I921
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	656	1.000	Inparanoid score	I755
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	1	1.000	-	-		mtm6388
orthoMCL	1	0.900	-	-		OOG6_100404
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.870