DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpB and CAPN14

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	NP_001138594.1	Gene:	CAPN14 / 440854	HGNCID:	16664	Length:	684	Species:	Homo sapiens

Alignment Length:	702	Identity:	250/702 - (35%)
Similarity:	374/702 - (53%)	Gaps:	67/702 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 DFQSLRDSCLANGTMFEDPDFPATNASL----MYSRRPDRYYEWLRPGDIADDPQFFVEGYSRFD 305
            ||::|...||.||.:|||..||||.:|:    :..:.|.| .:|.||.::..:|||:.....|.|
Human    29 DFEALLAECLRNGCLFEDTSFPATLSSIGSGSLLQKLPPR-LQWKRPPELHSNPQFYFAKAKRLD 92

  Fly   306 VQQGELGDCWLLAAAANLTQDSTLFFRVIPPDQDFQENYAGIFHFKFWQYGKWVEVVIDDRLPTY 370
            :.||.:||||.|||...|.....:..||:|.:|.|.|.|||||.|.||.||.||.||||||||..
Human    93 LCQGIVGDCWFLAALQALALHQDILSRVVPLNQSFTEKYAGIFRFWFWHYGNWVPVVIDDRLPVN 157

  Fly   371 N-GELIYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGGVTEWYDIKEAPPNLF 434
            . |:|:::.||.||.||.||||||||||.||||.|:.|...||:.|||||||...::.||..||:
Human   158 EAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSGQVSEALVDFTGGVTMTINLAEAHGNLW 222

  Fly   435 SIMMKAAERGSMMGCSLEPDPHVLEAETPQGLIRGHAYSITKVCLMDISTPNRQGKLPMIRMRNP 499
            .|:::|....:::||.......:||    .||:.||||::|.:  ..::..:|...|  :::|||
Human   223 DILIEATYNRTLIGCQTHSGEKILE----NGLVEGHAYTLTGI--RKVTCKHRPEYL--VKLRNP 279

  Fly   500 WGNDAEWSGPWSDSSPEWRFIPEHTKEEI-GLNFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLT 563
            ||. .||.|.|||||.:|..:  ..||:| .|..|.||||||:.|||..||..:.||.|:|..|:
Human   280 WGK-VEWKGDWSDSSSKWELL--SPKEKILLLRKDNDGEFWMTLQDFKTHFVLLVICKLTPGLLS 341

  Fly   564 EDQQHSSRRKWEMSMFEGEWTSGVTAGGCRNFL-ETFWHNPQYIISLEDPDDEDDDGK-----CT 622
            ::    :.:||..:|.||.|....||||.|..| :|||.|||:::|:..|    ::|:     |:
Human   342 QE----AAQKWTYTMREGRWEKRSTAGGQRQLLQDTFWKNPQFLLSVWRP----EEGRRSLRPCS 398

  Fly   623 AIVALMQK--NRRSKRNVGIDCLTIGFAIYHLT---DRDMQVKPQGLNFFKYRASVARSPHFINT 682
            .:|:|:||  :|..||.   ..|.|||.:|.:.   |...::.|:   ||:....:::...|:..
Human   399 VLVSLLQKPRHRCRKRK---PLLAIGFYLYRMNKYHDDQRRLPPE---FFQRNTPLSQPDRFLKE 457

  Fly   683 REVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETRNNME--ENDDEVGFGETDDRIAPSLPP 745
            :||.....|.||.|||||...:.:::.||::||||......|  .|...|...|.:|:
Human   458 KEVSQELCLEPGTYLIVPCILEAHQKSEFVLRVFSRKHIFYEIGSNSGVVFSKEIEDQ------- 515

  Fly   746 PTPKEEDDPQRIALRRLFDSVAGSDEEVDWQELKRILDHSMRDVMVGS--DGFSKDAVRSMVAML 808
               .|..|       ..|........|::..:|:.:| :.|....:||  ..||.:|.:.::|:|
Human   516 ---NERQD-------EFFTKFFEKHPEINAVQLQNLL-NQMTWSSLGSRQPFFSLEACQGILALL 569

  Fly   809 DKDRSGRLGFEEFEALLTDIAKWRAVFKLYDTRRTGSIDGFHLRGALNSAGYHLNNRLLNALAHR 873
            |.:.||.:..:||..|...:...:.||...| |.:|.::...|..|:..||..|::.:...:..|
Human   570 DLNASGTMSIQEFRDLWKQLKLSQKVFHKQD-RGSGYLNWEQLHAAMREAGIMLSDDVCQLMLIR 633

  Fly   874 YGSREGQIPFDDFLMCAIKVRTFIEMFRERDTDNSDTAFFNLDDWLERTIYS 925
            ||....|:.|..|:...::|....::|:.. |.:....:....:|:...:||
Human   634 YGGPRLQMDFVSFIHLMLRVENMEDVFQNL-TQDGKGIYLQKPEWMMMALYS 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042	137/301 (46%)
		Calpain_III	574..721	CDD:279416	54/157 (34%)
		EF-hand_7	759..825	CDD:290234	17/67 (25%)
		EFh	761..826	CDD:298682	18/66 (27%)
		FRQ1	827..>908	CDD:227455	19/80 (24%)
CAPN14	NP_001138594.1	Peptidase_C2	44..334	CDD:279042	137/301 (46%)
		Domain III	337..503		58/179 (32%)
		Calpain_III	348..496	CDD:279416	54/157 (34%)
		Linker	504..517		3/22 (14%)
		Domain IV	518..683		39/174 (22%)
		EFh	562..616	CDD:298682	15/54 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.880