DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpB and sol

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	NP_476738.3	Gene:	sol / 44014	FlyBaseID:	FBgn0003464	Length:	1594	Species:	Drosophila melanogaster

Alignment Length:	976	Identity:	206/976 - (21%)
Similarity:	324/976 - (33%)	Gaps:	349/976 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 SHAQNASYAGPTMGMGM-PVPEAPSAPA-PYPSATPYPGSGLYPSLPSANVSSLPYPTAPMAPYP 132
            ||.|      |.:.|.| .|.|.|...: ....|....|.|  .|...:..:.:..|||...|..
  Fly   770 SHRQ------PQLSMAMEAVRERPDGQSYEEQDAAAVGGGG--GSAHQSGANEVKAPTALNLPLT 826

  Fly   133 TGMPYPTGMPQPNLPYPAAPLAPYPSAMPGLPGMPMPYAPMPTSPAPQ--------------HNI 183
            :     ..:|.|.|..|.:..|       ||.|...|...|...|:.|              |:.
  Fly   827 S-----VALPMPMLQLPTSTAA-------GLRGSRSPSPRMQLLPSLQQQRNSSSSGAIPKRHST 879

  Fly   184 GFPALPYPTAPPPESAPTQEEEPSVGVAEL--------------SFTSVKVPENQNMFW------ 228
            |...:|...:....:....::...||.|.:              :.||.|.       |
  Fly   880 GGSIVPRNISIAGLANYNLQQGQGVGSASVVSASGAGSGAGAVGASTSTKK-------WQCPACT 937

  Fly   229 ---------------------------MGRKA-------TSARQNSVSKGDFQSLRDS------- 252
                                       :|||:       ...||.|....:.:.|.::
  Fly   938 YDNCAASVVCDICSSPRGLASAVLGEALGRKSVRVALTPADIRQESKLMENLRQLEETEALTKWQ 1002

  Fly   253 -----CLANGTMFEDPDFPATNASLMY-----SRRPDRYYEWLRPGDIADD----PQFFVEGYSR 303
                 |..|..:|.|..||....||.|     :...:...:|.||.:|..|    |.:.|
  Fly  1003 NIIQYCRDNSELFVDDSFPPAPKSLYYNPASGAGEGNPVVQWRRPHEINCDGGAYPPWAV----- 1062

  Fly   304 F------DVQQGELGDCWLLAAAANLTQDSTLFFRVIPPDQDFQENYAGIFHFKFWQYGKWVEVV 362
            |      |:.||.||:||||:|.|.|.:...|...|:...:...:   |.:..:..:.|||..|:
  Fly  1063 FRTPLPSDICQGVLGNCWLLSALAVLAEREDLVKEVLVTKEICGQ---GAYQVRLCKDGKWTTVL 1124

  Fly   363 IDDRLP-TYNGELIYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGGVTEWYDI 426
            :||.|| ...|.|:|..:..| :.|..|:|||.||:||.||||..|...|.:...||...|
  Fly  1125 VDDLLPCDKRGHLVYSQAKRK-QLWVPLIEKAVAKIHGCYEALVSGRAIEGLATLTGAPCE---- 1184

  Fly   427 KEAPPNLFSIMMKAAER----------------GSMMGCSLEPDPHVLEAETPQ--GLIRGHAYS 473
             ..|....|:.|.:.:.                ..:||.|.......::.|..|  ||...||||
  Fly  1185 -SIPLQASSLPMPSEDELDKDLIWAQLLSSRCVRFLMGASCGGGNMKVDEEEYQQKGLRPRHAYS 1248

  Fly   474 ITKVCLMDISTPNRQGKLPMIRMRNPWGNDAEWSGPWSDSSPEWRFIPEHTKEEIGLNFDRDGEF 538
            :..|  .||     ||. .::::|||||: ..|.|.|||.|..|   .:..::.:..:...:|.|
  Fly  1249 VLDV--KDI-----QGH-RLLKLRNPWGH-YSWRGDWSDDSSLW---TDDLRDALMPHGASEGVF 1301

  Fly   539 WMSFQDFLNHFDRVEICNLSPDSLTEDQQHSSRRKWEMSMFEGEWTSGVTAGGCRNFLETFWHNP 603
            |:||:|.||:||.::||.:             |..|.....:|.             |:......
  Fly  1302 WISFEDVLNYFDCIDICKV-------------RSGWNEVRLQGT-------------LQPLCSIS 1340

  Fly   604 QYIISLEDPDDED----DDGKCTAIVALMQKNRRSKRNVGIDCLTIGFAIYHLTDRDMQVKPQGL 664
            ..::::.:|.:.:    .:|:..:     :|::||:.::   |:.|
  Fly  1341 CVLLTVLEPTEAEFTLFQEGQRNS-----EKSQRSQLDL---CVVI------------------- 1378

  Fly   665 NFFKYRASVARS-----PHFINTREV-----CARFKLPPGHYLIVPSTF--------DPNEEGEF 711
              |:.|:..|..     .|  :.|:|     |.:. |....||:|...|        ||::..:.
  Fly  1379 --FRTRSPAAPEIGRLVEH--SKRQVRGFVGCHKM-LERDIYLLVCLAFNHWHTGIEDPHQYPQC 1438

  Fly   712 IIRVFSETRNNMEENDDEVGFGETDDRIAPSLPPPTPKEEDDPQRIALRRLFDSVAGSDEEVDWQ 776
            |:.:.|..|..:|:             |:||           |..:|
  Fly  1439 ILAIHSSKRLLVEQ-------------ISPS-----------PHLLA------------------ 1461

  Fly   777 ELKRILDHSMRDVMVGSDGFSKDAVRSMVAMLDKDRSGRLGFEEFEALLTDIAKWRAVFKLYDTR 841
                                  ||:.|:.....:...||.|...:  .||  ..|..:..:.:.|
  Fly  1462 ----------------------DAIISLTLTKGQRHEGREGMTAY--YLT--KGWAGLVVMVENR 1500

  Fly   842 RTG-----------SIDGFHLRGAL---------------------NSAGYHLNNRLLNALAHRY 874
            ...           |.:....||.|                     .|.|:.:.:||.:.||:..
  Fly  1501 HENKWIHVKCDCQESYNVVSTRGELKTVDSVPPLQRQVIIVLTQLEGSGGFSIAHRLTHRLANSR 1565

  Fly   875 G 875
            |
  Fly  1566 G 1566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403	38/184 (21%)
		Drf_FH1	37..189	CDD:283903	31/134 (23%)
		Peptidase_C2	260..556	CDD:279042	102/329 (31%)
		Calpain_III	574..721	CDD:279416	26/168 (15%)
		EF-hand_7	759..825	CDD:290234	6/65 (9%)
		EFh	761..826	CDD:298682	6/64 (9%)
		FRQ1	827..>908	CDD:227455	13/81 (16%)
sol	NP_476738.3	zf-RanBP	6..34	CDD:279035
		RanBP2-type Zn finger	10..29	CDD:275376
		zf-RanBP	135..164	CDD:279035
		zf-RanBP	643..672	CDD:279035
		RanBP2-type Zn finger	647..667	CDD:275375
		zf-RanBP	704..731	CDD:279035
		RanBP2-type Zn finger	708..727	CDD:275376
		zf-RanBP	747..774	CDD:279035	3/9 (33%)
		RanBP2-type Zn finger	749..768	CDD:275376
		zf-RanBP	927..954	CDD:279035	3/33 (9%)
		RanBP2-type Zn finger	931..950	CDD:275376	1/18 (6%)
		CysPc	1001..1328	CDD:128526	107/365 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448313
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850