DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpB and Capn11

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	NP_001002806.2	Gene:	Capn11 / 408218	RGDID:	1302946	Length:	715	Species:	Rattus norvegicus

Alignment Length:	745	Identity:	303/745 - (40%)
Similarity:	433/745 - (58%)	Gaps:	65/745 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 LSFTSVKVPE-------NQNMFWMGRKATSARQNSVS--KGDFQSLRDSCLANGTMFEDPDFPAT 268
            |:|:.:...|       |.|.  :..|.....||:.:  ..:|:.||.|||..|.:||||.|||.
  Rat     2 LNFSDISYAERGMVATINSNR--LKDKGVGQYQNAYNYKNQNFEDLRASCLKMGELFEDPFFPAE 64

  Fly   269 NASLMYSRRPDRYYE-----WLRPGDIADDPQFFVEGYSRFDVQQGELGDCWLLAAAANLTQDST 328
            ..|:.:.....:..|     |.||.||..:|||....:|..|:.||.|||||||||..:||....
  Rat    65 PQSIGFKELGPKSQEVHNVYWQRPKDIIHNPQFITNDFSPTDICQGILGDCWLLAAIGSLTTSPK 129

  Fly   329 LFFRVIPPDQDFQENYAGIFHFKFWQYGKWVEVVIDDRLPTYNGELIYMHSTEKNEFWSALLEKA 393
            |.|||:|..|.|::||||||||:.||:|.|:.||:||||||.|.:|:::|::.:.|||.||||||
  Rat   130 LLFRVVPRSQSFKKNYAGIFHFQLWQFGHWLNVVVDDRLPTKNNKLVFVHASHRQEFWGALLEKA 194

  Fly   394 YAKLHGSYEALKGGTTCEAMEDFTGGVTEWYDIKEAPPNLFSIMMKAAERGSMMGCSLE-PDPHV 457
            ||||:||||||.||:|.|.:||||||:.:...::..|.||..::.||.|:.|:||||:| .:...
  Rat   195 YAKLNGSYEALTGGSTMEGLEDFTGGMAQCIRLQNPPHNLLRLLRKALEKSSLMGCSIEATNSDD 259

  Fly   458 LEAETPQGLIRGHAYSITKVCLMDISTPNRQGKLPMIRMRNPWGNDAEWSGPWSDSSPEW-RFIP 521
            :|......|::||||:||.  |.|:...::...|  ||::||||. .||:|.|||.:.|| ..:|
  Rat   260 VEKMAHNMLVKGHAYAITG--LQDVYYRDKLETL--IRIQNPWGR-IEWNGAWSDKAKEWEEVMP 319

  Fly   522 E------HTKEEIGLNFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQHSSRRKWEMSMFE 580
            |      |.||        |||||||::||:::|..:|||||:||:|:.....|.   |..:.||
  Rat   320 EVQMQLLHKKE--------DGEFWMSYEDFMSNFTLLEICNLTPDALSSWDYKSC---WHTTFFE 373

  Fly   581 GEWTSGVTAGGCRNFLETFWHNPQYIISL---EDPDDEDDDGK--CTAIVALMQKNRRSKRNVGI 640
            |.|..|.|||||||:.||||.|||:.|||   :||:|..|..:  ||.:|||||||.|..|. |.
  Rat   374 GSWRRGSTAGGCRNYPETFWSNPQFRISLPETDDPEDSSDKSEMVCTCLVALMQKNWRHARE-GP 437

  Fly   641 DCLTIGFAIYHLTD-----RDMQVKPQGLNFFKYRASVARSPHFINTREVCARFKLPPGHYLIVP 700
            ..|||||.::.:..     :|:.:|..  .|.||| ....|..|.|||||.:..:||||.|:|:|
  Rat   438 QLLTIGFVVFSVPKEFQNLQDIHLKKD--FFMKYR-DHGFSEIFTNTREVNSHLRLPPGEYVIIP 499

  Fly   701 STFDPNEEGEFIIRVFSETRNNMEENDDEVGFGETDDRIAPSLPPPTPKEEDDPQRIALRRLFDS 765
            |||:|:::.:|::|||:| :::.....|||...|       .|...|..:.|..|...  .||::
  Rat   500 STFEPHKDADFLLRVFTE-KHSETWLLDEVNMLE-------QLQEETITDADLDQNSV--ELFET 554

  Fly   766 VAGSDEEVDWQELKRILDH-SMRDVMVGSDGFSKDAVRSMVAMLDKDRSGRLGFEEFEALLTDIA 829
            :|..|.:||..:|:::|:. |.:.....|.|||.|..|.||.::|||.||:||..||..|...|.
  Rat   555 LANRDSQVDMYDLQKLLNKMSSKFKSFKSKGFSLDVCRRMVNLMDKDDSGKLGLHEFHILWKKIK 619

  Fly   830 KWRAVFKLYDTRRTGSIDGFHLRGALNSAGYHLNNRLLNALAHRYGSREGQIPFDDFLMCAIKVR 894
            ||..:||..|..|:|:::.:.:|.|:..||..:|||:...:..||......:.||:|:.|.::::
  Rat   620 KWMEIFKECDQDRSGNLNSYEMRLAIEKAGIRMNNRVTEVVVARYADANMIVDFDNFINCFLRLK 684

  Fly   895 TFIEMFRERDTDNSDTAFFNLDDWLERTIY 924
            .....|...||..:.:...|::.||..|::
  Rat   685 AMFAFFLSMDTKKTGSICLNINQWLHITMW 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403	4/18 (22%)
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042	145/308 (47%)
		Calpain_III	574..721	CDD:279416	73/156 (47%)
		EF-hand_7	759..825	CDD:290234	26/66 (39%)
		EFh	761..826	CDD:298682	27/65 (42%)
		FRQ1	827..>908	CDD:227455	24/80 (30%)
Capn11	NP_001002806.2	Peptidase_C2	56..352	CDD:279042	145/308 (47%)
		Calpain_III	367..520	CDD:279416	73/157 (46%)
		Linker. /evidence=ECO:0000250\|UniProtKB:Q9UMQ6	528..543		4/21 (19%)
		Domain IV. /evidence=ECO:0000250\|UniProtKB:Q9UMQ6	544..714		56/171 (33%)
		EFh	591..641	CDD:238008	21/49 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	112	1.000	Domainoid score	I6051
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48339
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100404
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.830