DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CalpB and zgc:85932

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	NP_998104.1	Gene:	zgc:85932 / 405875	ZFINID:	ZDB-GENE-040426-2460	Length:	671	Species:	Danio rerio

Alignment Length:	673	Identity:	225/673 - (33%)
Similarity:	342/673 - (50%)	Gaps:	52/673 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   259 MFEDPDFPATNASLMYSRRPDRYYEWLRPGDIADDPQFFVEGYSRFDVQQGELGDCWLLAAAANL 323
            ::.|..||..|..:...      ..|.||.:|...|||.|:|.:|.|:.|..|||||.|:|.|:|
Zfish    45 LYVDTRFPVQNMPVQND------LVWRRPKEICLFPQFIVDGATRMDICQVVLGDCWFLSAVASL 103

  Fly   324 TQDSTLFFRVIPPDQDFQENYAGIFHFKFWQYGKWVEVVIDDRLPTYNGELIYMHSTEKNEFWSA 388
            :....|..||:|..|.||:.|.|.|.|:|||||:|:.|.|||.|||.|.:|||:||..::|||||
Zfish   104 SLYPALLDRVVPAGQGFQQGYNGCFCFQFWQYGEWISVKIDDLLPTCNNQLIYLHSASRDEFWSA 168

  Fly   389 LLEKAYAKLHGSYEALKGGTTCEAMEDFTGGVTEWYDIKEAPPNLFSIMMKAAERGSMMGCSLEP 453
            |||||||||.|.|.||..|...|||.|.|||:||.:.:...|..|.|.:....|:|:::.|:...
Zfish   169 LLEKAYAKLKGGYSALNMGFPHEAMVDMTGGITEVFMVASLPRALGSFLRSLLEKGALINCANSQ 233

  Fly   454 DPHVLEAETPQGLIRGHAYSITKVCLMDISTPNRQGKLPMIRMRNPWGNDAEWSGPWSDSSP-EW 517
            .|  ||.....|::..||||:|.:    .:..:..|.:.::|:|||||. |||.|||||... ||
Zfish   234 GP--LEKSNEFGILFRHAYSVTAL----ETVKSTIGPVQLVRIRNPWGK-AEWEGPWSDKKGIEW 291

  Fly   518 RFIPEHTKEEIGLNFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQHSSRRKWEMSMFEGE 582
            ..:....:..:......|||||||..||..:|:.:|:|:||.|:|:|.   ..::.|:.:...|:
Zfish   292 HMVTAEEQRRVQRIQQEDGEFWMSLADFRQNFELMEVCHLSEDTLSEG---DVKKPWKCTSHHGQ 353

  Fly   583 WTSGVTAGGCRNFLETFWHNPQYIISL--EDPDDEDDDGKCTAIVALMQKNRRSKRNVGIDCLTI 645
            ||             ....:|||.::|  ||.|..|.:..|:.::|||||:.|.:..:    |:|
Zfish   354 WT-------------PLQGSPQYNLTLLEEDDDPSDPELTCSFLLALMQKHTRQRGTL----LSI 401

  Fly   646 GFAIYHLTDRDMQVKPQGLNFFKYRASVARSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGE 710
            ...||...|..:..:...|      .|..:...|....|:..|.:|.||||:|:|:..:.|:.||
Zfish   402 ALHIYKARDHGVSSRESPL------LSTTKDQGFQQRPELVLRSRLAPGHYIIIPAIQETNQSGE 460

  Fly   711 FIIRVFSETRNNMEENDDEVGFGETDDRIAPSLPPP-TPKEEDDPQRIALRRLFDSVAGSDEEVD 774
            |::||.:| :.|.....:..|.. ||     ||..| :|:....|.....|.||...........
Zfish   461 FLLRVLTE-KGNTTTAAERAGVA-TD-----SLTQPLSPRLTGLPSTNEARDLFVKHCAKGPYCR 518

  Fly   775 WQELKRILDHSM-RDVMVGSDG-FSKDAVRSMVAMLDKDRSGRLGFEEFEALLTDIAKWRAVFKL 837
            ..:|..:|..:: :.|..||:. .|.:..:|.|.::|....|||...||:||...:.||.::|..
Zfish   519 PLDLYNLLTEAISKGVFAGSEKMLSLEHCKSFVVLMDSQGMGRLDLTEFQALWDKLRKWTSIFIT 583

  Fly   838 YDTRRTGSIDGFHLRGALNSAGYHLNNRLLNALAHRYGSREGQIPFDDFLMCAIKVRTFIEMFRE 902
            :|..:..::|...:..||::||..::..:|..::.||...:..:.|..||...:|:...:..|:.
Zfish   584 FDKNKNQALDYLEISPALSAAGIKVDEFILQLISLRYTEPDMTLSFPGFLFLLMKLDCMMRKFQS 648

  Fly   903 RDTDNSDTAFFNLDDWLERTIYS 925
            .|...:.....|...:|..|:|:
Zfish   649 FDVTGTGMISVNCRQFLHMTMYN 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042	126/296 (43%)
		Calpain_III	574..721	CDD:279416	43/148 (29%)
		EF-hand_7	759..825	CDD:290234	18/67 (27%)
		EFh	761..826	CDD:298682	18/66 (27%)
		FRQ1	827..>908	CDD:227455	18/80 (23%)
zgc:85932	NP_998104.1	Peptidase_C2	46..330	CDD:279042	126/296 (43%)
		Calpain_III	345..471	CDD:279416	43/149 (29%)
		FRQ1	572..>660	CDD:227455	18/87 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580197
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.950