DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpB and capn1a

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	NP_956739.1	Gene:	capn1a / 393417	ZFINID:	ZDB-GENE-040426-1263	Length:	704	Species:	Danio rerio

Alignment Length:	696	Identity:	327/696 - (46%)
Similarity:	449/696 - (64%)	Gaps:	44/696 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 DFQSLRDSCLANGTMFEDPDFPATNASLMYSR-----RPDRYYEWLRPGDIADDPQFFVEGYSRF 304
            |:::||..||..|.:||||.|||...||.:..     ...|..||:||.::.|||||.|.|.:|.
Zfish    34 DYEALRQECLEGGYLFEDPCFPAEPPSLGFKELAPHSSKTRDVEWMRPTELCDDPQFIVGGATRT 98

  Fly   305 DVQQGELGDCWLLAAAANLTQDSTLFFRVIPPDQDFQENYAGIFHFKFWQYGKWVEVVIDDRLPT 369
            |:.||.|||||||||..:||.:..|..||:|..|.||::|||||||:|||:|:||::|||||||.
Zfish    99 DICQGALGDCWLLAAIGSLTLNERLLHRVVPHGQSFQDDYAGIFHFQFWQFGEWVDIVIDDRLPV 163

  Fly   370 YNGELIYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGGVTEWYDIKEAPPNLF 434
            .:|||:::||.|.|||||||:|||||||:||||||.||:|.|..|||||||:|.|::::||.:|:
Zfish   164 KDGELMFVHSAEGNEFWSALVEKAYAKLNGSYEALSGGSTTEGFEDFTGGVSEMYELRKAPRDLY 228

  Fly   435 SIMMKAAERGSMMGCSLE-PDPHVLEAETPQGLIRGHAYSITKVCLMDISTPNRQGKLPMIRMRN 498
            .|:.||.:|||::|||:: .....:|:.|.:.|::|||||:|  .|..:....|..:|  ||:||
Zfish   229 RIISKALDRGSLLGCSIDITSAFDMESVTFKKLVKGHAYSVT--ALKQVEYRGRMERL--IRIRN 289

  Fly   499 PWGNDAEWSGPWSDSSPEWRFIPEHTKEEIGLNFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLT 563
            ||| ..||:|.|||:||||..|....|:::.|..: ||||||||.:||..|.|:|||||:||:|:
Zfish   290 PWG-QVEWTGAWSDNSPEWDEIDPSEKDDLHLQME-DGEFWMSFGEFLRQFSRLEICNLTPDALS 352

  Fly   564 EDQQHSSRRKWEMSMFEGEWTSGVTAGGCRNFLETFWHNPQYIISL--EDPDDEDDDGKCTAIVA 626
            :|..    ..|....|.|.|..|.|||||||...|||.||||.|:|  ||.|.||::..|:.:||
Zfish   353 DDDM----SHWNTIKFHGAWRRGSTAGGCRNHPNTFWINPQYKITLLEEDDDPEDEEVACSFLVA 413

  Fly   627 LMQKNRRSKRNVGIDCLTIGFAIYHLTD-----RDMQVKPQGLNFFKYRASVARSPHFINTREVC 686
            ||||:||..|..|.|..|||||||.:.:     :::.:|.   :||...:|.|||..|||.|||.
Zfish   414 LMQKDRRRYRGQGQDMHTIGFAIYEVPEEYTGCQNVHLKK---DFFLSNSSAARSETFINLREVS 475

  Fly   687 ARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETRNNMEENDDEVGFG-ETDDRIAPSLPPPTPKE 750
            .|.:||||.|:||||||:|::|.:|::|||:|.::..||.|||:... |.::.|       |..:
Zfish   476 TRLRLPPGEYIIVPSTFEPSKEADFVLRVFTEKQSETEELDDEISADLEDEEEI-------TEDD 533

  Fly   751 EDDPQRIALRRLFDSVAGSDEEVDWQELKRILDHSM---RDVMVGSDGFSKDAVRSMVAMLDKDR 812
            .||    :.:.||..:||.|.|:...|||.||:..:   :||.  :||||.|:.|:||.:||||.
Zfish   534 IDD----SFKSLFAQLAGEDMEISVHELKTILNRVVSKHKDVK--TDGFSMDSCRTMVNLLDKDG 592

  Fly   813 SGRLGFEEFEALLTDIAKWRAVFKLYDTRRTGSIDGFHLRGALNSAGYHLNNRLLNALAHRYGSR 877
            |.|||..||:.|...|.|...:|:.:|..::|::..:.:|.|:.|||:.|||||...|..||...
Zfish   593 SARLGLVEFQILWNKIRKLLGIFREFDIDKSGTMSSYEMRLAVESAGFKLNNRLNQILVARYAEN 657

  Fly   878 EGQIPFDDFLMCAIKVRTFIEMFRERDTDNSDTAFFNLDDWLERTI 923
            |. |.||:|:.|.||:......|::.|.:.:.||..||.:||..|:
Zfish   658 EA-IDFDNFVCCLIKLEAMFRSFQQLDREETGTAEMNLSEWLFMTM 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042	160/301 (53%)
		Calpain_III	574..721	CDD:279416	77/153 (50%)
		EF-hand_7	759..825	CDD:290234	31/68 (46%)
		EFh	761..826	CDD:298682	32/67 (48%)
		FRQ1	827..>908	CDD:227455	28/80 (35%)
capn1a	NP_956739.1	Peptidase_C2	49..345	CDD:279042	160/301 (53%)
		Calpain_III	359..510	CDD:279416	77/153 (50%)
		EFh	581..631	CDD:298682	19/49 (39%)
		EFh	610..>664	CDD:298682	20/54 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	358	1.000	Domainoid score	I921
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	656	1.000	Inparanoid score	I755
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	1	1.000	-	-		mtm6388
orthoMCL	1	0.900	-	-		OOG6_100404
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.870