Protein Alignment CalpB and Capn13

DIOPT Version :10

• Sequence 1: NP_524016.4
• Gene: CalpB / 39165
• FlyBaseID: FBgn0025866
• Length: 925
• Species: Drosophila melanogaster
• Sequence 2: NP_001028616.1
• Gene: Capn13 / 381122
• MGIID: 2685789
• Length: 665
• Species: Mus musculus
• Alignment Length: 728
• Identity: 223/728 - (30%)
• Similarity: 341/728 - (46%)
• Gaps: 125/728 - (17%)

  Fly   245 DFQSLRDSCLANGTMFEDPDFPATNAS----LMYSRRPDRYYEWLRPGDIADD-----PQFFVEG 300
            ||::|||.||:.|.:|.|..|||..:|    |:..:...: .||.||  .:.|     |.|.:||
Mouse    16 DFRTLRDHCLSRGQLFIDDTFPAAASSIGEKLLRGKHLSK-LEWKRP--TSKDLPFYPPHFILEG 77

  Fly   301 YSRFDVQQGELGDCWLLAAAANLTQDSTLFFRVIPPDQDFQENYAGIFHFKFWQYGKWVEVVIDD 365
            .||||:.||..||||.|||..:|||:.....::: .||.:...|||||.|:|||.|:||||||||
Mouse    78 ASRFDIHQGIAGDCWFLAALGSLTQNPQCLQKIL-MDQSYSHQYAGIFQFRFWQCGQWVEVVIDD 141

  Fly   366 RLPTYNGELIYMHSTEKN-EFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGGVTEWYDIKEA 429
            :||......:::|....| |||..|:|||||||.|||..|..|...:|:.|.||||....::..:
Mouse   142 QLPVIGDNFLFVHPRGGNKEFWPCLMEKAYAKLLGSYSQLHYGYLPDALVDLTGGVVTIINLHSS 206

  Fly   430 PPNLFSIMMKAAERGSMMGCSLE----PDPHVLEAETPQGLIRGHAYSIT---KVCLMDISTPNR 487
            |.:|.:.:..|.:.|||:.|:.|    .:..|:|    .||:..|||::|   |:        ..
Mouse   207 PFDLLTTVKTAIQAGSMVACATENGLTEEAKVME----NGLVSQHAYTVTGAEKI--------QY 259

  Fly   488 QGKL-PMIRMRNPWGNDAEWSGPWSDSSPEWRFIPEHTKEEIGLNFDRDGEFWMSFQDFLNHFDR 551
            ||:. .:||:.||||. .||.|.|.|.|.|||...:..|.::..| ..|||||||.|||..:|..
Mouse   260 QGRWEDIIRLWNPWGK-TEWKGRWKDGSKEWRETHDPRKSQLYEN-KEDGEFWMSCQDFQENFSC 322

  Fly   552 VEICNLSPDSLTEDQQHSSRRKWEMSMFEGEWTSGVTAGGCRNFLETFWHNPQYIISLEDPDDED 616
            :.|||..|  :|.|...:....|....|..:..|...|||       ...:.||:.|::    |.
Mouse   323 LFICNQIP--ITMDHGVTPNESWRQMRFTNQVISRNRAGG-------HGRDMQYVFSVQ----EH 374

  Fly   617 DDGKCTAIVA--LMQKNRRSKRNVGIDCLTIGFAIYHLTDRDMQVKPQGLN--------FFKYRA 671
            ..|. ..:||  :|.::..::.    :...:.|.::.:        ||..|        ||....
Mouse   375 TAGN-NVVVAFTIMPQSLNTEE----ERFPLQFQVFKV--------PQFQNVQGRLPPAFFSPFR 426

  Fly   672 SVARSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETRNNMEENDDEVGFGETD 736
            |.|:...:::.......|.|.||.|::|  |....:|.||::|:|
Mouse   427 SAAQGTKYVSKCNFTKSFHLNPGTYVVV--TTANGKEVEFLLRIF-------------------- 469

  Fly   737 DRIAPSLPPPTPKEEDDPQRIALRRLFDSVA--GS---------DE--EVDWQELKRILDHSMRD 788
                  |..| .|..|......||.|.:|:.  ||         |:  ::|..:|:.:|:   ::
Mouse   470 ------LKMP-DKHRDPSSNFNLRALKESLPENGSRNSISYTYMDQGLDIDATQLQSLLN---QE 524

  Fly   789 VMVG--SDGFSKDAVRSMVAMLDKDRSGRLGFEEFEALLTDIAKWRAVFKLYDTRRTGSIDGFHL 851
            .:.|  .|.||.|..:|::|::|...:|||..|||..|.:.:...:.:|:... ||.|.:....|
Mouse   525 FLTGPPGDTFSLDQCQSIMALMDLKVNGRLDQEEFARLRSRLIHCQHIFQSIQ-RRPGVLLSSDL 588

  Fly   852 RGALNS----AGYHLNNRLLNALAHRYGSREGQIPFDDFLMCAIKVRTFIEMFRERDTDNSDTAF 912
            ...:.:    .|..:::.||:.:|.||....|::.|...:...|::.|..:.||....|... .:
Mouse   589 WKVIENTDFLVGIFISSELLSLMALRYSDSSGRVSFPTLVCFLIRLETMAKAFRNLSKDGKG-IY 652

  Fly   913 FNLDDWLERTIYS 925
            ....:|:...:||
Mouse   653 LTETEWMNLVMYS 665

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_524016.4	PHA03247	<40..207	CDD:223021
		Peptidase_C2	260..556	CDD:459889	126/313 (40%)
		Calpain_III	579..716	CDD:460050	32/146 (22%)
		EFh_PEF_CalpA_B	758..925	CDD:320071	44/185 (24%)
		EF-hand motif	758..786	CDD:320071	10/40 (25%)
		EF-hand motif	799..829	CDD:320071	11/29 (38%)
		EF-hand motif	830..860	CDD:320071	5/33 (15%)
		EF-hand motif	866..894	CDD:320071	8/27 (30%)
		EF-hand motif	895..925	CDD:320071	5/29 (17%)
Capn13	NP_001028616.1	Peptidase_C2	31..327	CDD:459889	126/313 (40%)
		Calpain_III	366..469	CDD:469636	27/121 (22%)
		EFh_PEF_CAPN13_14	505..665	CDD:320070	38/164 (23%)
		EF-hand motif	538..567	CDD:320070	10/28 (36%)
		EF-hand motif	568..601	CDD:320070	5/33 (15%)
		EF-hand motif	607..635	CDD:320070	8/27 (30%)
		EF-hand motif	637..665	CDD:320070	4/28 (14%)