DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpB and Capn13

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	NP_001020304.1	Gene:	Capn13 / 362701	RGDID:	1562682	Length:	668	Species:	Rattus norvegicus

Alignment Length:	724	Identity:	233/724 - (32%)
Similarity:	354/724 - (48%)	Gaps:	83/724 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 MGRKATSARQNSVSK---GDFQSLRDSCLANGTMFEDPDFPATNAS-----LMYSRRPDRYYEWL 285
            |.....:..:.||.|   .||:.|||.||:.|.:|.|..|||..:|     ||..|.|.  .||.
  Rat     1 MAHDTEALEETSVVKFKNQDFRFLRDRCLSRGQLFIDDTFPAEASSIGQKLLMGKRLPK--LEWK 63

  Fly   286 RPGDIA-DDPQFFVEGYSRFDVQQGELGDCWLLAAAANLTQDSTLFFRVIPPDQDFQENYAGIFH 349
            ||.|:: ..|.|.:||.||||:|||..||||.|||..:|||:.....::: .:|.|...||||||
  Rat    64 RPQDLSFGPPHFILEGASRFDIQQGRAGDCWFLAALGSLTQNPQCLQKIL-MNQSFSYQYAGIFH 127

  Fly   350 FKFWQYGKWVEVVIDDRLPTYNGELIYMHSTEKN-EFWSALLEKAYAKLHGSYEALKGGTTCEAM 413
            |:|||.|:|||||||||||.......::|....| |||..|:|||||||.|||..|..|...:|:
  Rat   128 FRFWQCGQWVEVVIDDRLPVVGNNFCFVHPRRGNQEFWPCLMEKAYAKLLGSYSQLHYGYLPDAL 192

  Fly   414 EDFTGGVTEWYDIKEAPPNLFSIMMKAAERGSMMGCS----LEPDPHVLEAETPQGLIRGHAYSI 474
            .|.||||....::..:|.:|..::..|.:.|||:.|:    |..:..|:|    .||:..|||::
  Rat   193 VDLTGGVVTRINLHSSPSDLLMVVKTAVQTGSMVACATPKWLTEESEVME----NGLVSQHAYTV 253

  Fly   475 T---KVCLMDISTPNRQGKLPMIRMRNPWGNDAEWSGPWSDSSPEWRFIPEHTKEEIGLNFDRDG 536
            |   |:       ..|:|...:||:.||||| .||.|.|.|.|.||.......|.::..|.| ||
  Rat   254 TGAEKI-------QYRRGWEEIIRLWNPWGN-TEWRGRWGDGSQEWWETHGSRKSQLYENKD-DG 309

  Fly   537 EFWMSFQDFLNHFDRVEICNLSPDSLTEDQQHSSRRKWEMSMFEGEWTSGVTAGGCRNFLETFWH 601
            |||||.:||..:|..:.||:..|  :|.|...:....|....|:.:..||.||||....:
  Rat   310 EFWMSCRDFHENFSCLYICSQFP--ITMDPGVTPNESWRQMRFKNQVISGNTAGGDGRDI----- 367

  Fly   602 NPQYIISLEDPDDEDDDGKCTAIVA--LMQKNRRSKRNVGIDCLTIGFAIYHLTDRDMQVKPQGL 664
              ||:..:::|.|.::     .|||  :|.::.:::...    ..:.|.::.: |...|...:.|
  Rat   368 --QYLFDVQEPMDGNN-----VIVAFTVMPQSLKTEEWP----FPLQFQVFKV-DSQFQKFQKRL 420

  Fly   665 --NFFKYRASVARSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETRNNMEEND 727
              .||......|:...::..|.....|.|.||.|::|.|..  .:|.||::|:|.:    |...|
  Rat   421 PPAFFSQFRDAAQGIDYVTKRNFTKSFHLSPGTYVVVASAH--GKEVEFLLRIFLK----MPHKD 479

  Fly   728 DEVGFGETDDRIAPSLPPPTPKEEDDPQRIALRRLFDSVAGSDEEVDWQELKRILDHSMRDVMVG 792
            ...........:..||      .|::..:.:..|..|.  |.|  :|..:|:.:|:   ::.:.|
  Rat   480 RNPNSSFNLKALKGSL------SENESPKSSFHRYMDQ--GLD--IDASQLQSLLN---QEYLTG 531

  Fly   793 --SDGFSKDAVRSMVAMLDKDRSGRLGFEEFEALLTDIAKWRAVFKLYDTRRTGSIDGFHLRGAL 855
              .|.||.|..:|::|::|...:|||..|||..|.:.:...:.||: :..|..|.:....|...:
  Rat   532 PPGDTFSLDQCQSIMALMDLKVNGRLDREEFARLQSRLIHCQHVFQ-HIQRSQGVLRSSDLWEVI 595

  Fly   856 NS----AGYHLNNRLLNALAHRYGSREGQIPFDDFLMCAIKVRTFIEMFRERDTDNSDTAFFNLD 916
            .|    :|..|:..||:.:..||....|::.|...:...|::.|..:.||....|.. :.:....
  Rat   596 ESTDFLSGVLLSKELLSLMTLRYSDSSGRLSFPSLVCFLIRLETMSKAFRNLSKDGK-SIYLTEM 659

  Fly   917 DWLERTIYS 925
            :|::..:||
  Rat   660 EWMKLVMYS 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042	132/309 (43%)
		Calpain_III	574..721	CDD:279416	36/150 (24%)
		EF-hand_7	759..825	CDD:290234	21/67 (31%)
		EFh	761..826	CDD:298682	22/66 (33%)
		FRQ1	827..>908	CDD:227455	19/84 (23%)
Capn13	NP_001020304.1	Peptidase_C2	35..329	CDD:279042	132/309 (43%)
Capn13	NP_001020304.1	Calpain_III	345..477	CDD:294111	37/154 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340362
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.810