Protein Alignment CalpB and CalpC

DIOPT Version :10

• Sequence 1: NP_524016.4
• Gene: CalpB / 39165
• FlyBaseID: FBgn0025866
• Length: 925
• Species: Drosophila melanogaster
• Sequence 2: NP_573118.2
• Gene: CalpC / 32597
• FlyBaseID: FBgn0260450
• Length: 681
• Species: Drosophila melanogaster
• Alignment Length: 730
• Identity: 215/730 - (29%)
• Similarity: 338/730 - (46%)
• Gaps: 113/730 - (15%)

  Fly   246 FQSLRDSCLANGTMFEDPDFPATNASLMYSRRPDRYYEWLRPGDIADD------------PQFFV 298
            ::.:...|.:...::|||||||..:|:.|.:.|...::|.|..|:||.            |.|..
  Fly     5 YERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPPFTFQWKRIMDLADSGSGAVAANSSAAPVFLN 69

  Fly   299 EGYSRFDVQQGELGDCWLLAAAANLTQDSTLFFRVIPPDQDFQENYAGIFHFKFWQYGKWVEVVI 363
            |. :.|||..|::||.||::....|:....||:||:|.||.....: |:|.|:.|..|:||||::
  Fly    70 ES-AEFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCGEWVEVLV 132

  Fly   364 DDRLPTYNGELIYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGGVTEWYDIKE 428
            ||||||.||.|.:|.....|.||:||||||.|||||||||||.||..:.:.|..|||.....|..
  Fly   133 DDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGVVRQMPILS 197

  Fly   429 ---APPNLFSIMMKAAERGSMMGCSLEPDPHV----LEAETPQGLIRGHAY-------------- 472
               .|..|..::....    ::.|..:....|    |....|.|::....|
  Fly   198 DNIRPQTLKELLTTTC----IVTCLADKSATVAKKNLAERMPNGILVNVNYRLSSLDKVKTLMGD 258

  Fly   473 SITKVCLMDISTPNRQGKLPMIRMRNPWGNDAEWSGPWSDSSPEWRFIPEHTK----EEIGLNFD 533
            |:..|||.|..:            ..|:|....:.|.||..|..|..:.:..:    .::|
  Fly   259 SVQLVCLKDTFS------------SKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQLG---- 307

  Fly   534 RDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQHSSR-RKWEMSMFEGEWTSGVTAGGCRNFLE 597
             .||||:||.||:..|..:|:..|..::..:::...|| ..|:|.|.:|:|..|||||||||. |
  Fly   308 -PGEFWLSFCDFVEIFSTMEVVYLDTETSNDEEMLKSRPLHWKMKMHQGQWKRGVTAGGCRNH-E 370

  Fly   598 TFWHNPQYIISLEDPDDEDDDGKCTAIVALMQKNRRSKRNVGIDCLTIGFAIYHLTDRDMQVKPQ 662
            :|..|||.:||::|..|        .::||.|       :..::...|||.:|......|..:..
  Fly   371 SFHINPQLLISVQDEQD--------LVIALNQ-------HTAVEPKVIGFTMYTWDGEYMLSECL 420

  Fly   663 GLNFFKYRASVARSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETRNNMEEND 727
            ..:|||...|...| .:.|||.|.....|..|||:::|:|::|.||..|.:|:
  Fly   421 QKDFFKNHVSYLNS-DYGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRI------------ 472

  Fly   728 DEVGFG-------ETDDRIAPSLPPPTPKEEDDPQRIA---------LRRLFDSVAGSDEEVDWQ 776
              :|.|       ||...|.  |.|....:..|.:|..         ...::..:|..::.::..
  Fly   473 --LGTGSFRLSCLETQTMIL--LDPFPALKSTDAERCGGPKVKSVCQYEPVYMQLADENKTINCF 533

  Fly   777 ELKRILDHSM-RDVMVGSDGFSKDAVRSMVAMLDKDRSGRLGFEEFEALLTDIAKWRAVFKLYDT 840
            ||..:|:..: .|.:.|....  |..|.::|:.|:..|||:.|::|:..:.::..|:.|||:|..
  Fly   534 ELHELLEACLPNDYIKGCANI--DICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTK 596

  Fly   841 RRTGSIDGFHLRGALNSAGYHLNNRLLNALAHRYGSREGQIPFDDFLMCAIKVRTFIEMFRERDT 905
            .:.|.:....||.||...|:.|:..::|.|..||..::|.:...||:...|.:.|....|..::.
  Fly   597 EKAGILRAERLRDALCDIGFQLSTDIMNCLIQRYIRKDGTLRLSDFVSAVIHLTTAFNQFHLKNY 661

  Fly   906 DNSDTAFFNLDDWLE 920
            ...:....:|.||::
  Fly   662 GQVNVIEVHLHDWIK 676

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_524016.4	PHA03247	<40..207	CDD:223021
		Peptidase_C2	260..556	CDD:459889	111/332 (33%)
		Calpain_III	579..716	CDD:460050	48/136 (35%)
		EFh_PEF_CalpA_B	758..925	CDD:320071	40/173 (23%)
		EF-hand motif	758..786	CDD:320071	4/36 (11%)
		EF-hand motif	799..829	CDD:320071	9/29 (31%)
		EF-hand motif	830..860	CDD:320071	10/29 (34%)
		EF-hand motif	866..894	CDD:320071	8/27 (30%)
		EF-hand motif	895..925	CDD:320071	5/26 (19%)
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	112/344 (33%)
		Calpain_III	346..483	CDD:238132	53/167 (32%)
		EFh_PEF	515..680	CDD:355382	40/164 (24%)
		EF-hand motif	515..543	CDD:320054	4/27 (15%)
		EF-hand motif	556..585	CDD:320054	8/28 (29%)
		EF-hand motif	586..615	CDD:320054	10/28 (36%)
		EF-hand motif	622..650	CDD:320054	8/27 (30%)
		EF-hand motif	652..680	CDD:320054	4/25 (16%)