Protein Alignment CalpB and Capn12

DIOPT Version :10

• Sequence 1: NP_524016.4
• Gene: CalpB / 39165
• FlyBaseID: FBgn0025866
• Length: 925
• Species: Drosophila melanogaster
• Sequence 2: XP_038967508.1
• Gene: Capn12 / 308476
• RGDID: 1307341
• Length: 766
• Species: Rattus norvegicus
• Alignment Length: 709
• Identity: 263/709 - (37%)
• Similarity: 396/709 - (55%)
• Gaps: 70/709 - (9%)

  Fly   233 ATSARQNSVSKG-DFQSLRDSCLANGTMFEDPDFPATNASLMYSR-RPD----RYYEWLRPGDIA 291
            |..|....:.|| :::::|.:||.:|.:|.||.|||...:|.|.: .||    :..||.||.:..
  Rat    18 AAGAGGPQLFKGQNYEAIRAACLDSGILFRDPCFPAGPDALGYDKLGPDSEKAKGVEWKRPHEFC 82

  Fly   292 DDPQFFVEGYSRFDVQQGELGDCWLLAAAANLTQDSTLFFRVIPPDQDFQENYAGIFHFKFWQYG 356
            .:|||..|..||.||.||.||:||||||||:||....|.:||:||.|.||:.|||:|||:.||:|
  Rat    83 AEPQFICEDMSRTDVCQGSLGNCWLLAAAASLTLYPRLLYRVVPPGQGFQDGYAGVFHFQLWQFG 147

  Fly   357 KWVEVVIDDRLPTYNGELIYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGGVT 421
            :||:||:||:||..:|:|:::.|.::||||:.||||||||||||||.::||...||..||||||.
  Rat   148 RWVDVVVDDKLPVRDGKLLFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGHMNEAFVDFTGGVG 212

  Fly   422 EWYDIKEAPPNLFSIMMKAAERGSMMGCSLEPDPHVLEAETPQGLIRGHAYSITKVCLMDISTPN 486
            |...:::..|.:|:.:..|..:.|::|.:...|..  |..|.:||::|||||:|....|.:...
  Rat   213 EVLYLRQNTPGVFAALRHALAKESLVGATALSDRG--EIRTDEGLVKGHAYSVTGTHKMSLGFT- 274

  Fly   487 RQGKLPMIRMRNPWGNDAEWSGPWSDSSPEWRFIPEHTKEEIGLNFDRDGEFWMSFQDFLNHFDR 551
               |:.::|:|||||. .|||||||||.|.|..:|...::.: |....||||||..||||.||:.
  Rat   275 ---KVRLLRLRNPWGR-VEWSGPWSDSCPRWDMLPSEWRDAL-LVKKEDGEFWMELQDFLTHFNT 334

  Fly   552 VEICNLSPDSLTEDQQHSSRRKWEMSMFEGEWTSGVTAGGCRNFLETFWHNPQYIISLEDPDDED 616
            |:||:|||:.|........   |.:..|:|.|..|..:||.:...|.||.|||:.::|.:||:|:
  Rat   335 VQICSLSPEVLGPSPAGGG---WHIHTFQGRWVRGFNSGGSQPSAENFWTNPQFRLTLLEPDEEE 396

  Fly   617 DDG-----------------------KCTAIVALMQKNRRSKRNVGIDCLTIGFAIYHLTDRDMQ 658
            |:.                       |||.:::|:|:|||..|..|:..||:||.::       |
  Rat   397 DEDDEEGPWGGWGAAGARPARGGRVPKCTVLLSLIQRNRRCLRAKGLTYLTVGFHVF-------Q 454

  Fly   659 VKPQGLNFFKYRASVARSPH--------FINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRV 715
            :..:.|..:....|.|..|.        |...|:|..|.:|||||||:|||.....:|.:|.:|:
  Rat   455 IPEELLGLWDSPRSRALLPGLLRADRSVFCARRDVSRRCRLPPGHYLVVPSASRVGDEADFTLRI 519

  Fly   716 FSETRNNMEENDDEVGFGETDDRIAPSLPPPTPKEEDDPQRIALRRLFDSVAGSDEEVDWQELKR 780
            |||..:...|.||.:. .:.|...||.          .|..:.|.:||..:||.:||::..:|:.
  Rat   520 FSERSHTAVEIDDVIS-ADLDALQAPY----------KPLELELAQLFLELAGEEEELNALQLQT 573

  Fly   781 ILDHSMRDVMVGSDGFSKDAVRSMVAMLD-KDRSGRLGFEEFEALLTDIAKWRAVFKLYDTRRTG 844
            ::..::......:....:..:|:...::. ..|..||....|:.|...:..|:|.|..:|...:|
  Rat   574 LISIALEPARNNTRTSGEIGLRTCEQLVQCFGRGQRLALYHFQELWGHLLSWQATFDKFDEDASG 638

  Fly   845 SIDGFHLRGALNSAGYHLNNRLLNALAHRYGSREGQIPFDDFLMCAIKVRTFIEMFRER 903
            :::...||.||.:||:||||:|..||..||.:...::.|:.|:.||.::..   :||||
  Rat   639 TMNSCELRLALTAAGFHLNNQLTQALTSRYRNSRLRVDFEHFVCCAARLTC---IFRER 694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_524016.4	PHA03247	<40..207	CDD:223021
		Peptidase_C2	260..556	CDD:459889	144/300 (48%)
		Calpain_III	579..716	CDD:460050	53/167 (32%)
		EFh_PEF_CalpA_B	758..925	CDD:320071	42/147 (29%)
		EF-hand motif	758..786	CDD:320071	8/27 (30%)
		EF-hand motif	799..829	CDD:320071	6/30 (20%)
		EF-hand motif	830..860	CDD:320071	10/29 (34%)
		EF-hand motif	866..894	CDD:320071	9/27 (33%)
		EF-hand motif	895..925	CDD:320071	4/9 (44%)
Capn12	XP_038967508.1	Peptidase_C2	46..339	CDD:459889	144/300 (48%)
		Calpain_III	352..530	CDD:238132	57/187 (30%)
		EFh_PEF	567..693	CDD:355382	32/128 (25%)
		EF-hand motif	596..623	CDD:320069	5/26 (19%)
		EF-hand motif	624..653	CDD:320069	9/28 (32%)
		EF-hand motif	660..688	CDD:320069	9/27 (33%)