DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpB and Capn15

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	XP_008765793.1	Gene:	Capn15 / 303000	RGDID:	1306514	Length:	1193	Species:	Rattus norvegicus

Alignment Length:	1122	Identity:	257/1122 - (22%)
Similarity:	374/1122 - (33%)	Gaps:	402/1122 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EVSGGNEGGGAPKPKAGLY---PSLPYPSSE------------SVGGMPYVVKQ-TSH----AQN 74
            |..|.::....|...|||.   |:..:|..|            :..|..:..:: |.|    |.:
  Rat   162 EPKGNSKEETGPVRTAGLVATEPARGHPEKEEEEKEQEDDGERADPGSGWACQRCTLHNTPVASS 226

  Fly    75 ASYAGPTMGMGMP--------VPE--APSA--PAPYPSATPYPGSGLYPSLPSANVSSLPYPT-- 125
            .|..|....:.:|        |||  ||:.  ..|.||....||.|.....||  .|..|..|
  Rat   227 CSACGGPRKLSLPRIPPEALVVPEVVAPTGFHVVPPPSQPALPGEGAEAESPS--TSQGPTSTDQ 289

  Fly   126 --------APMAPYPTGMPYPTGM----PQPNLPYP------AAPLAPYPSAMPG---------- 162
                    :|.:|.....|.|...    ||...|.|      |:..:..|...||
  Rat   290 EPPRVPLFSPFSPTLQNNPVPRSRREVPPQLQPPVPEGAQSSASTSSKGPQQGPGRAAAGASRLA 354

  Fly   163 --------LPGMPMPY----APMPTSPA---------------PQHNIGFPALP----------- 189
                    |||..:..    || .:|||               .::....|:.|
  Rat   355 ELLSGKELLPGKRLSVLEEEAP-ESSPARCESCSDVIDLAGDVVRYTPASPSSPDFTTWSCARCT 418

  Fly   190 --YPT-------------------APPPESAP---TQEEEPSVG----------VAEL------- 213
              .||                   :.||...|   ..:..|.||          .|.|
  Rat   419 LRNPTTASRCSVCGGSKLHGFQEHSEPPTHCPDCGADKPGPCVGSCGRAPSAHKAARLLPDRPGQ 483

  Fly   214 ----SFTSVKVPE---------NQNMFWMGRKATSAR---------QNSVSKGDFQSLRDS---- 252
                :.|.:..|.         .|.:....|.||..|         :....:|:.::|.::
  Rat   484 WACPACTLINTPRAKHCAACHTPQLLVTQCRGATPLRRRESMHVEKRRQTDEGEAKALWENIVAF 548

  Fly   253 CLANGTMFEDPDFPATNASLMY---SRRPDRYYEWLRPGDIADDPQFFVEG--YSRF------DV 306
            |..|...|.|..||...||:.:   .....|..:||||.:| :...|...|  :|.|      |:
  Rat   549 CRENSVNFVDDSFPPGPASVGFPVGDSVQQRVKQWLRPHEI-NCSVFRDHGTPWSVFHTLRPSDI 612

  Fly   307 QQGELGDCWLLAAAANLTQDSTLFFRVIPPDQDFQENYAGIFHFKFWQYGKWVEVVIDDRLPTYN 371
            .||.||:||.|:|.|.|.:...|..||:.......|   |.:..:..:.|.|..|::||.||...
  Rat   613 LQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAE---GAYQVRLCKDGTWTTVLVDDMLPCDE 674

  Fly   372 GELIYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGGVTEWYDIKEAPPN---- 432
            ...:.....::.:.|.||:|||.|||||||.||:.|...|.:...||...|...::.:..|
  Rat   675 AGFLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGLATLTGAPCESLALQVSSTNPREE 739

  Fly   433 ------LFSIMMKAAERGSMMGCS-----LEPDPHVLEAETPQGLIRGHAYSITKVCLMDISTPN 486
                  :::.|:.:.|.|.:||.|     ::.|....|:   .||...||||:..|  .|:
  Rat   740 PVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDAAYES---LGLRPRHAYSVLDV--RDV---- 795

  Fly   487 RQGKLPMI----RMRNPWGNDAEWSGPWSDSSPEWRFIPEHTKEEIGLNFDRDGEFWMSFQDFLN 547
             ||..|:|    |:|||||. ..|:|.|||..|.|   |.|.:.|:..:...:|.|||.:.||:.
  Rat   796 -QGSSPVIHRLLRLRNPWGR-FSWNGSWSDEWPHW---PGHLRAELMPHGSSEGVFWMEYSDFIR 855

  Fly   548 HFDRVEICNLSPDSLTEDQQHSSRRKWEMSMFEGEWTS------GVTAGGCRNFLETFWHNPQYI 606
            :||.|:||.:..|             |:.:..:|.:.|      ||||   ...||.
  Rat   856 YFDSVDICKVHSD-------------WQEARVQGCFPSTASGPVGVTA---LTVLER-------- 896

  Fly   607 ISLEDPDDEDDDGKCTAIVALMQKNRRSKRNVGIDCLTIGFAIYHLTDRDMQVKPQGLNFFKYRA 671
            .|||              .||.|:.  |:|:..:|.        ||.|         |....:||
  Rat   897 ASLE--------------FALFQEG--SRRSDSVDS--------HLLD---------LCILVFRA 928

  Fly   672 S------------VARSPH----FINTREVCARFKLPPGHYLIVPSTFD--------PNEEGEFI 712
            :            :|.|..    |:|     ....|.||.|.:|...|:        |..:|:
  Rat   929 TFGTGGRLSLGRLLAHSKRAVKKFVN-----CDVMLEPGEYAVVCCAFNHWNPAPPGPPAQGK-- 986

  Fly   713 IRVFSETRNNMEENDDEVGFGETDDRIAPSLP------PP---------TPKEEDDPQRIALRRL 762
                                |.:..|..|:.|      ||         ||.....|.
  Rat   987 --------------------GPSQMRPTPAFPSSEPQSPPAGKLLAPLSTPPTASSPS------- 1024

  Fly   763 FDSVAGSDEEVDWQELKRILDHSMRDVMVGSDGFSKDAVRSMVAMLDKDR----SGRLGFEEFEA 823
                ||............:..:|.|.|||.........:...:.:|.:.|    .||.|...:
  Rat  1025 ----AGVPRGAPEPPGHVLAVYSSRLVMVEPVEAQPTTLADAIILLTESRGERHEGREGMTCY-- 1083

  Fly   824 LLTDIAKWRAVFKLYDTRRTGS--------IDGFHL---RGAL---------------------N 856
            .||.  .|..:..:.:.|...|        .|.|::   ||:|                     .
  Rat  1084 YLTH--GWAGLIVVVENRHPKSYLHVQCDCTDSFNVVSTRGSLRTQDSVPPLHRQVLVILSQLEG 1146

  Fly   857 SAGYHLNNRLLNALAHR 873
            :||:.:.:|    ||||
  Rat  1147 NAGFSITHR----LAHR 1159

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403	65/345 (19%)
		Drf_FH1	37..189	CDD:283903	51/240 (21%)
		Peptidase_C2	260..556	CDD:279042	106/325 (33%)
		Calpain_III	574..721	CDD:279416	36/176 (20%)
		EF-hand_7	759..825	CDD:290234	12/69 (17%)
		EFh	761..826	CDD:298682	12/68 (18%)
		FRQ1	827..>908	CDD:227455	15/79 (19%)
Capn15	XP_008765793.1	ZnF_RBZ	71..95	CDD:197784
		RanBP2-type Zn finger	73..92	CDD:275376
		ZnF_RBZ	113..135	CDD:197784
		RanBP2-type Zn finger	114..133	CDD:275376
		PHA03247	<137..380	CDD:223021	49/220 (22%)
		ZnF_RBZ	211..233	CDD:197784	5/21 (24%)
		RanBP2-type Zn finger	211..230	CDD:275376	4/18 (22%)
		ZnF_RBZ	412..434	CDD:197784	2/21 (10%)
		RanBP2-type Zn finger	412..431	CDD:275376	2/18 (11%)
		RanBP2-type Zn finger	449..464	CDD:275375	4/14 (29%)
		ZnF_RBZ	482..506	CDD:197784	2/23 (9%)
		RanBP2-type Zn finger	484..503	CDD:275376	2/18 (11%)
		CysPc	544..864	CDD:238004	108/337 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820