DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CalpB and Pef1

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	NP_001007652.1	Gene:	Pef1 / 297900	RGDID:	1359536	Length:	283	Species:	Rattus norvegicus

Alignment Length:	188	Identity:	53/188 - (28%)
Similarity:	87/188 - (46%)	Gaps:	20/188 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   745 PPTPKEED------DPQRIALRRLFDSV-AGSDEEVDWQELKRILDHSMRDVMVGSDGFSKDAVR 802
            ||.|..:.      ||:..:   .|.|| |.....:..:|||:.|.:|      ....|:.:...
  Rat   101 PPGPYGQGGVPPNVDPEAYS---WFQSVDADHSGYISLKELKQALVNS------NWSSFNDETCL 156

  Fly   803 SMVAMLDKDRSGRLGFEEFEALLTDIAKWRAVFKLYDTRRTGSIDGFHLRGALNSAGYHLNNRLL 867
            .|:.|.||.::||:....|.||...:.:|:.:|:.||...:|||....|:.||:..||:|:.:..
  Rat   157 MMINMFDKTKTGRIDVVGFSALWKFLQQWKNLFQQYDRDHSGSISSTELQQALSQMGYNLSPQFT 221

  Fly   868 NALAHRYGSREGQIP---FDDFLMCAIKVRTFIEMFRERDTDNSDTAFFNLDDWLERT 922
            ..|..||.:|.. ||   .|.|:....:::...|.|||:||........:.:|::..|
  Rat   222 QLLVSRYCTRSA-IPAMQLDCFIKVCTQLQVLTEAFREKDTAVQGNIRLSFEDFVTMT 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042
		Calpain_III	574..721	CDD:279416
		EF-hand_7	759..825	CDD:290234	18/66 (27%)
		EFh	761..826	CDD:298682	19/65 (29%)
		FRQ1	827..>908	CDD:227455	27/83 (33%)
Pef1	NP_001007652.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44
		9 X 9 AA approximate tandem repeat of [AP]-P-G-G-P-Y-G-G-P-P	21..108		3/6 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	56..114		3/12 (25%)
		EF-hand_7	122..178	CDD:290234	17/61 (28%)
		EFh	122..171	CDD:238008	16/54 (30%)
		EF-hand_6	184..213	CDD:290141	10/28 (36%)
		EF-hand_7	186..277	CDD:290234	27/91 (30%)
		EFh	186..277	CDD:298682	27/91 (30%)
		Required for interaction with PDCD6. /evidence=ECO:0000250\|UniProtKB:Q9UBV8	203..283		22/77 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910