DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpB and Capn2

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	NP_058812.1	Gene:	Capn2 / 29154	RGDID:	2268	Length:	700	Species:	Rattus norvegicus

Alignment Length:	707	Identity:	323/707 - (45%)
Similarity:	447/707 - (63%)	Gaps:	66/707 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 DFQSLRDSCLANGTMFEDPDFPATNASL------MYSRRPDRYYEWLRPGDIADDPQFFVEGYSR 303
            |:::||:.||..|.:|:||.|||..:||      .||.: .|..||.||.:|..||||.:.|.:|
  Rat    31 DYETLRNECLEAGALFQDPSFPALPSSLGFKELGPYSSK-TRGIEWKRPTEICADPQFIIGGATR 94

  Fly   304 FDVQQGELGDCWLLAAAANLTQDSTLFFRVIPPDQDFQENYAGIFHFKFWQYGKWVEVVIDDRLP 368
            .|:.||.|||||||||.|:||.:..:..||:|.||.|||||||||||:|||||:|||||:|||||
  Rat    95 TDICQGALGDCWLLAAIASLTLNEEILARVVPLDQSFQENYAGIFHFQFWQYGEWVEVVVDDRLP 159

  Fly   369 TYNGELIYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGGVTEWYDIKEAPPNL 433
            |.:|||:::||.|.:|||||||||||||::|.||||.||.|.|..||||||:.|||::::.||||
  Rat   160 TKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELRKPPPNL 224

  Fly   434 FSIMMKAAERGSMMGCSLE----PDPHVLEAETPQGLIRGHAYSITKVCLMDISTPNRQGKL-PM 493
            |.|:.||.|:||::|||::    .|.   ||.|.|.|::|||||:|....::.|     |.| .:
  Rat   225 FKIIQKALEKGSLLGCSIDITSAADS---EAVTYQKLVKGHAYSVTGAEEVESS-----GSLQKL 281

  Fly   494 IRMRNPWGNDAEWSGPWSDSSPEWRFIPEHTKEEIGLNFDRDGEFWMSFQDFLNHFDRVEICNLS 558
            ||:||||| ..||:|.|:|:.|.|..:....:..: .....||||||||.|||.|:.|:|||||:
  Rat   282 IRIRNPWG-QVEWTGKWNDNCPSWNTVDPEVRANL-TERQEDGEFWMSFSDFLRHYSRLEICNLT 344

  Fly   559 PDSLTEDQQHSSRRKWEMSMFEGEWTSGVTAGGCRNFLETFWHNPQYIISLEDPDDEDDDGK--C 621
            ||:||.|    |.:||:::..:|.|..|.|||||||:..|||.||||:|.||:.|::|:||:  |
  Rat   345 PDTLTCD----SYKKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDDEDGERGC 405

  Fly   622 TAIVALMQKNRRSKRNVGIDCLTIGFAIYHLTDRDMQVKPQGL----------NFFKYRASVARS 676
            |.:|.|:||:||.:|.:|.|..||||.||.:        |:.|          |||....:..||
  Rat   406 TFLVGLIQKHRRRQRKMGEDMHTIGFGIYEV--------PEELTGQTNIHLSKNFFLTTRARERS 462

  Fly   677 PHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETRNNMEENDDEVGFGETDDRIAP 741
            ..|||.|||..|||||||.|::|||||:|::.|:|.||||||.:.:.:..|||         |..
  Rat   463 DTFINLREVLNRFKLPPGEYVLVPSTFEPHKNGDFCIRVFSEKKADYQTVDDE---------IEA 518

  Fly   742 SLPPPTPKEEDDPQRIALRRLFDSVAGSDEEVDWQELKRILDHSMRDVM-----VGSDGFSKDAV 801
            ::......|||...  ..||||..:||.|.|:...||:.||    |.|:     :.|||||.:..
  Rat   519 NIEEIEANEEDIGD--GFRRLFAQLAGEDAEISAFELQTIL----RRVLAKREDIKSDGFSIETC 577

  Fly   802 RSMVAMLDKDRSGRLGFEEFEALLTDIAKWRAVFKLYDTRRTGSIDGFHLRGALNSAGYHLNNRL 866
            :.||.|||:|.||:||.:||..|.|.|.|::.:::..|..|:|:::.:.:|.||..||:.|..:|
  Rat   578 KIMVDMLDEDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKLPCQL 642

  Fly   867 LNALAHRYGSREGQIPFDDFLMCAIKVRTFIEMFRERDTDNSDTAFFNLDDWLERTI 923
            ...:..|:...|..|.||:|:.|.:::....::|::.|.:|:.|...:|..||..::
  Rat   643 HQVIVARFADDELIIDFDNFVRCLVRLEILFKIFKQLDPENTGTIQLDLISWLSFSV 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042	164/306 (54%)
		Calpain_III	574..721	CDD:279416	77/158 (49%)
		EF-hand_7	759..825	CDD:290234	31/70 (44%)
		EFh	761..826	CDD:298682	31/69 (45%)
		FRQ1	827..>908	CDD:227455	21/80 (26%)
Capn2	NP_058812.1	Peptidase_C2	46..342	CDD:279042	164/306 (54%)
		Domain III	345..514		84/180 (47%)
		Calpain_III	356..507	CDD:279416	77/158 (49%)
		Linker	515..529		3/22 (14%)
		Domain IV	530..700		59/176 (34%)
		EFh	577..631	CDD:238008	20/53 (38%)
		FRQ1	604..>696	CDD:227455	25/91 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	159	1.000	Domainoid score	I3983
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	641	1.000	Inparanoid score	I782
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100404
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.870