DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpB and Capn11

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	XP_011244781.1	Gene:	Capn11 / 268958	MGIID:	1352490	Length:	753	Species:	Mus musculus

Alignment Length:	739	Identity:	293/739 - (39%)
Similarity:	431/739 - (58%)	Gaps:	64/739 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   210 VAELSFTSVK---VPENQNMFWMGRKATSARQNSVSKGDFQSLRDSCLANGTMFEDPDFPATNAS 271
            ||.::.:.:|   |.::||.:            :....:::.||..||..|.:||||.|||...|
Mouse    54 VATINHSRLKDKGVGQHQNAY------------NYKNQNYEDLRAECLRKGELFEDPFFPAEPRS 106

  Fly   272 L------MYSRRPDRYYEWLRPGDIADDPQFFVEGYSRFDVQQGELGDCWLLAAAANLTQDSTLF 330
            :      ..|......| |.||.||..:|||....:|..|:.||.|||||||||..:||....|.
Mouse   107 IGVKNLGPNSEHMQNIY-WQRPKDIIHNPQFITNDFSPTDICQGILGDCWLLAAIGSLTTCPKLL 170

  Fly   331 FRVIPPDQDFQENYAGIFHFKFWQYGKWVEVVIDDRLPTYNGELIYMHSTEKNEFWSALLEKAYA 395
            :||:|.:|.|::||||||||:.||:|.|:.||:||||||.|.:|:::|::.:.:|||||||||||
Mouse   171 YRVVPRNQSFKKNYAGIFHFQLWQFGHWLNVVVDDRLPTRNNKLVFVHASHRQDFWSALLEKAYA 235

  Fly   396 KLHGSYEALKGGTTCEAMEDFTGGVTEWYDIKEAPPNLFSIMMKAAERGSMMGCSLE-PDPHVLE 459
            ||.|||.||.||:|.|.:|||||||.:...:::.|.|:..::.||.|:.|:||||:| .|...:|
Mouse   236 KLIGSYGALSGGSTLEGLEDFTGGVAQCIPLQKPPGNMLRLLKKALEKSSLMGCSIEVTDNSEVE 300

  Fly   460 AETPQGLIRGHAYSITKVCLMDISTPNRQGKLPMIRMRNPWGNDAEWSGPWSDSSPEWRFIPEHT 524
            ..|...|:|||||::|.  |.|:...::...|  ||::||||. .||:|.|||.:.||..:....
Mouse   301 TMTHNMLVRGHAYAVTG--LEDVYYRDKLETL--IRIQNPWGR-VEWNGAWSDKATEWEEVSPDV 360

  Fly   525 KEEIGLNFDRDGEFWMSFQDFLNHFDRVEICNLSPDSL-TEDQQHSSRRKWEMSMFEGEWTSGVT 588
            :.:: |:...||:||||::||:::|..:|||||:||:| |.|.    :.:|..:.:||.|..|.|
Mouse   361 RVQL-LHKKDDGDFWMSYEDFMSNFTLLEICNLTPDALNTWDY----KSRWHSTFYEGSWRRGST 420

  Fly   589 AGGCRNFLETFWHNPQYIISLEDPDDEDDDGK-----CTAIVALMQKNRRSKRNVGIDCLTIGFA 648
            ||||||..||||.|||:.|||.:.||.:||.:     ||.:|||||||.|..|. |...|||||.
Mouse   421 AGGCRNHPETFWSNPQFKISLPEVDDPEDDSEKNEMVCTCLVALMQKNWRHARE-GPQLLTIGFV 484

  Fly   649 IYHLTD-----RDMQVKPQGLNFFKYRASVARSPHFINTREVCARFKLPPGHYLIVPSTFDPNEE 708
            |:.:..     ||:.:|..  .|.||| ....|..|||:|||.:..:||||.|:|:|||::|:::
Mouse   485 IFSVPKEFQNLRDIHLKKD--FFLKYR-DHGFSEIFINSREVNSHLRLPPGEYVIIPSTYEPHKD 546

  Fly   709 GEFIIRVFSETRNNMEENDDEVGFGETDDRIAPSLPPPTPKEEDDPQRIALRRLFDSVAGSDEEV 773
            .:|::|||:|..:.....||...|....:...      |.|:.|...    .:||..:|..|.||
Mouse   547 ADFLLRVFTEKHSETWLLDDANRFEHLQEETV------TDKDLDKDS----LQLFKIMANEDGEV 601

  Fly   774 DWQELKRILDH---SMRDVMVGSDGFSKDAVRSMVAMLDKDRSGRLGFEEFEALLTDIAKWRAVF 835
            |...|.::|:.   .:|:..  :.|||.:..|.|:.:||||.||:|...||:.|...|.||..:|
Mouse   602 DMYALHKLLNRMTAKLRNFK--TKGFSLEVCRRMINLLDKDGSGKLELHEFQVLWKKIKKWTEIF 664

  Fly   836 KLYDTRRTGSIDGFHLRGALNSAGYHLNNRLLNALAHRYGSREGQIPFDDFLMCAIKVRTFIEMF 900
            |..|..|:|:::.:.:|.|:..||..:|||:...:..|| |....:.||.||.|.::::.....|
Mouse   665 KECDEDRSGNLNSYEMRLAIEKAGIKMNNRVTEVVVARY-SDNMIVDFDSFLNCFLRLKAMFAFF 728

  Fly   901 RERDTDNSDTAFFNLDDWLERTIY 924
            ...||..:.:...:::.||:.|::
Mouse   729 LSMDTKKTGSICLDINQWLQITMW 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403	4/17 (24%)
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042	141/302 (47%)
		Calpain_III	574..721	CDD:279416	73/156 (47%)
		EF-hand_7	759..825	CDD:290234	24/68 (35%)
		EFh	761..826	CDD:298682	25/67 (37%)
		FRQ1	827..>908	CDD:227455	26/80 (33%)
Capn11	XP_011244781.1	Peptidase_C2	95..391	CDD:366222	141/302 (47%)
		Calpain_III	413..559	CDD:366446	71/149 (48%)
		EFh_PEF_CAPN11	586..753	CDD:320068	54/174 (31%)
		EF-hand motif	586..614	CDD:320068	9/31 (29%)
		EF-hand motif	629..658	CDD:320068	12/28 (43%)
		EF-hand motif	659..688	CDD:320068	9/28 (32%)
		EF-hand motif	695..722	CDD:320068	8/27 (30%)
		EF-hand motif	724..752	CDD:320068	6/27 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48339
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100404
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.830