Protein Alignment CalpB and Capn11

DIOPT Version :10

• Sequence 1: NP_524016.4
• Gene: CalpB / 39165
• FlyBaseID: FBgn0025866
• Length: 925
• Species: Drosophila melanogaster
• Sequence 2: XP_011244781.1
• Gene: Capn11 / 268958
• MGIID: 1352490
• Length: 753
• Species: Mus musculus
• Alignment Length: 739
• Identity: 293/739 - (39%)
• Similarity: 431/739 - (58%)
• Gaps: 64/739 - (8%)

  Fly   210 VAELSFTSVK---VPENQNMFWMGRKATSARQNSVSKGDFQSLRDSCLANGTMFEDPDFPATNAS 271
            ||.::.:.:|   |.::||.:            :....:::.||..||..|.:||||.|||...|
Mouse    54 VATINHSRLKDKGVGQHQNAY------------NYKNQNYEDLRAECLRKGELFEDPFFPAEPRS 106

  Fly   272 L------MYSRRPDRYYEWLRPGDIADDPQFFVEGYSRFDVQQGELGDCWLLAAAANLTQDSTLF 330
            :      ..|......| |.||.||..:|||....:|..|:.||.|||||||||..:||....|.
Mouse   107 IGVKNLGPNSEHMQNIY-WQRPKDIIHNPQFITNDFSPTDICQGILGDCWLLAAIGSLTTCPKLL 170

  Fly   331 FRVIPPDQDFQENYAGIFHFKFWQYGKWVEVVIDDRLPTYNGELIYMHSTEKNEFWSALLEKAYA 395
            :||:|.:|.|::||||||||:.||:|.|:.||:||||||.|.:|:::|::.:.:|||||||||||
Mouse   171 YRVVPRNQSFKKNYAGIFHFQLWQFGHWLNVVVDDRLPTRNNKLVFVHASHRQDFWSALLEKAYA 235

  Fly   396 KLHGSYEALKGGTTCEAMEDFTGGVTEWYDIKEAPPNLFSIMMKAAERGSMMGCSLE-PDPHVLE 459
            ||.|||.||.||:|.|.:|||||||.:...:::.|.|:..::.||.|:.|:||||:| .|...:|
Mouse   236 KLIGSYGALSGGSTLEGLEDFTGGVAQCIPLQKPPGNMLRLLKKALEKSSLMGCSIEVTDNSEVE 300

  Fly   460 AETPQGLIRGHAYSITKVCLMDISTPNRQGKLPMIRMRNPWGNDAEWSGPWSDSSPEWRFIPEHT 524
            ..|...|:|||||::|.  |.|:...::...|  ||::||||. .||:|.|||.:.||..:....
Mouse   301 TMTHNMLVRGHAYAVTG--LEDVYYRDKLETL--IRIQNPWGR-VEWNGAWSDKATEWEEVSPDV 360

  Fly   525 KEEIGLNFDRDGEFWMSFQDFLNHFDRVEICNLSPDSL-TEDQQHSSRRKWEMSMFEGEWTSGVT 588
            :.:: |:...||:||||::||:::|..:|||||:||:| |.|.    :.:|..:.:||.|..|.|
Mouse   361 RVQL-LHKKDDGDFWMSYEDFMSNFTLLEICNLTPDALNTWDY----KSRWHSTFYEGSWRRGST 420

  Fly   589 AGGCRNFLETFWHNPQYIISLEDPDDEDDDGK-----CTAIVALMQKNRRSKRNVGIDCLTIGFA 648
            ||||||..||||.|||:.|||.:.||.:||.:     ||.:|||||||.|..|. |...|||||.
Mouse   421 AGGCRNHPETFWSNPQFKISLPEVDDPEDDSEKNEMVCTCLVALMQKNWRHARE-GPQLLTIGFV 484

  Fly   649 IYHLTD-----RDMQVKPQGLNFFKYRASVARSPHFINTREVCARFKLPPGHYLIVPSTFDPNEE 708
            |:.:..     ||:.:|..  .|.||| ....|..|||:|||.:..:||||.|:|:|||::|:::
Mouse   485 IFSVPKEFQNLRDIHLKKD--FFLKYR-DHGFSEIFINSREVNSHLRLPPGEYVIIPSTYEPHKD 546

  Fly   709 GEFIIRVFSETRNNMEENDDEVGFGETDDRIAPSLPPPTPKEEDDPQRIALRRLFDSVAGSDEEV 773
            .:|::|||:|..:.....||...|....:...      |.|:.|...    .:||..:|..|.||
Mouse   547 ADFLLRVFTEKHSETWLLDDANRFEHLQEETV------TDKDLDKDS----LQLFKIMANEDGEV 601

  Fly   774 DWQELKRILDH---SMRDVMVGSDGFSKDAVRSMVAMLDKDRSGRLGFEEFEALLTDIAKWRAVF 835
            |...|.::|:.   .:|:..  :.|||.:..|.|:.:||||.||:|...||:.|...|.||..:|
Mouse   602 DMYALHKLLNRMTAKLRNFK--TKGFSLEVCRRMINLLDKDGSGKLELHEFQVLWKKIKKWTEIF 664

  Fly   836 KLYDTRRTGSIDGFHLRGALNSAGYHLNNRLLNALAHRYGSREGQIPFDDFLMCAIKVRTFIEMF 900
            |..|..|:|:::.:.:|.|:..||..:|||:...:..|| |....:.||.||.|.::::.....|
Mouse   665 KECDEDRSGNLNSYEMRLAIEKAGIKMNNRVTEVVVARY-SDNMIVDFDSFLNCFLRLKAMFAFF 728

  Fly   901 RERDTDNSDTAFFNLDDWLERTIY 924
            ...||..:.:...:::.||:.|::
Mouse   729 LSMDTKKTGSICLDINQWLQITMW 752

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_524016.4	PHA03247	<40..207	CDD:223021
		Peptidase_C2	260..556	CDD:459889	141/302 (47%)
		Calpain_III	579..716	CDD:460050	69/146 (47%)
		EFh_PEF_CalpA_B	758..925	CDD:320071	54/170 (32%)
		EF-hand motif	758..786	CDD:320071	9/30 (30%)
		EF-hand motif	799..829	CDD:320071	12/29 (41%)
		EF-hand motif	830..860	CDD:320071	10/29 (34%)
		EF-hand motif	866..894	CDD:320071	8/27 (30%)
		EF-hand motif	895..925	CDD:320071	6/30 (20%)
Capn11	XP_011244781.1	Peptidase_C2	95..391	CDD:459889	141/302 (47%)
		Calpain_III	405..564	CDD:238132	73/162 (45%)
		EFh_PEF_CAPN11	586..753	CDD:320068	54/174 (31%)
		EF-hand motif	586..614	CDD:320068	9/31 (29%)
		EF-hand motif	629..658	CDD:320068	12/28 (43%)
		EF-hand motif	659..689	CDD:320068	10/29 (34%)
		EF-hand motif	695..722	CDD:320068	8/27 (30%)
		EF-hand motif	723..753	CDD:320068	6/30 (20%)