Protein Alignment CalpB and Capn10

DIOPT Version :10

• Sequence 1: NP_524016.4
• Gene: CalpB / 39165
• FlyBaseID: FBgn0025866
• Length: 925
• Species: Drosophila melanogaster
• Sequence 2: NP_035926.2
• Gene: Capn10 / 23830
• MGIID: 1344392
• Length: 666
• Species: Mus musculus
• Alignment Length: 503
• Identity: 166/503 - (33%)
• Similarity: 235/503 - (46%)
• Gaps: 78/503 - (15%)

  Fly   259 MFEDPDFPATNASLMYSR-------RPDRYYEWLRPGDIADDPQFFVEGYSRFDVQQGELGDCWL 316
            :|.|..|||:::||.|:.       |.|  ..|.||.:|...||.|.:......|:||.|||||.
Mouse    13 LFRDAAFPASDSSLFYNLSTPLAQFRED--ITWRRPQEICATPQLFPDNPWEGQVKQGLLGDCWF 75

  Fly   317 LAAAANLTQDSTLFFRVIPPDQD--FQENYAGIFHFKFWQYGKWVEVVIDDRLPTYNGELIYMHS 379
            |.|.|.|.:...|..:|.||.|.  ..:.|.|.|..:.||:|.|.||.||||||...|.|.:...
Mouse    76 LCACAALQKSQHLLDQVFPPGQPGWSDQKYQGFFTCRIWQFGHWEEVTIDDRLPCLAGRLCFSRC 140

  Fly   380 TEKNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGGVTEWYDIKEAPPNLFSIMMKAA--- 441
            ..::.||..||||||||:|||||.|..|...:|:.|.||.:.|.:.:|:        :.||:
Mouse   141 QREDVFWLPLLEKAYAKVHGSYEHLWAGQVADALVDLTGSLAERWSLKD--------VTKASGQQ 197

  Fly   442 ERGS-----------------MMGCS-LEPDPHVLEAETPQGLIRGHAYSITKVCLMDISTPNRQ 488
            :|.|                 ::.|| |.|.....|      |...||:.|:.  |.::.:...|
Mouse   198 DRPSGGEHRTCRQLLHLKDRCLISCSVLSPRAGARE------LGEFHAFIISD--LQELRSQTGQ 254

  Fly   489 GKLPMIRMRNPWGNDAEWSGPWSDSSPEWRFIPEHTKEEIGLNFDRDGEFWMSFQDFLNHFDRVE 553
            |.| ::|:.||||... |.|.|.:....|..: |..||...|...::||||:..::||..||.|.
Mouse   255 GIL-LLRIHNPWGRRC-WQGLWREGGEGWNQV-EPAKESELLAQLQEGEFWVEEEEFLREFDEVT 316

  Fly   554 ICNLSPDSLTEDQQHSSRRKWEMSMFEGEWTSGVTAGGCRNFLETFWHNPQYIISLEDPDDEDDD 618
            |.....::......|:.|.........|.|.:|.:|||||| ...|..||::.:.|.:|.:
Mouse   317 IGYPVTEAGHLQSLHTERVLCHTRTLPGAWVTGQSAGGCRN-NSCFPCNPKFWLRLLEPSE---- 376

  Fly   619 GKCTAIVALMQKNRRSKRNVGIDCLTIGF--AIYHLTDRDMQVKPQGLNFFKYRASVARSPHFIN 681
                ..||::|:.||  |.||......|.  |..:|..:|.|.  .||:.:|........|..::
Mouse   377 ----VCVAVLQRPRR--RLVGQTRALAGASPAPVNLPGKDYQA--VGLHIWKVEKRKISLPRVLS 433

  Fly   682 T------------REVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFS 717
            .            ||:..|.:|.||:||.|||||..:..|:|::||||
Mouse   434 APPVAGTACHAYDREIHLRCELSPGYYLAVPSTFLKDVPGQFLLRVFS 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_524016.4	PHA03247	<40..207	CDD:223021
		Peptidase_C2	260..556	CDD:459889	114/325 (35%)
		Calpain_III	579..716	CDD:460050	47/150 (31%)
		EFh_PEF_CalpA_B	758..925	CDD:320071
		EF-hand motif	758..786	CDD:320071
		EF-hand motif	799..829	CDD:320071
		EF-hand motif	830..860	CDD:320071
		EF-hand motif	866..894	CDD:320071
		EF-hand motif	895..925	CDD:320071
Capn10	NP_035926.2	CysPc	8..319	CDD:238004	114/326 (35%)
		Domain III 1	322..488		52/173 (30%)
		calpain_III	338..488	CDD:214786	50/157 (32%)
		Calpain_III	506..647	CDD:238132
		Domain III 2	507..648