DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CalpB and clpr-1

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	NP_493397.3	Gene:	clpr-1 / 189180	WormBaseID:	WBGene00012233	Length:	252	Species:	Caenorhabditis elegans

Alignment Length:	245	Identity:	55/245 - (22%)
Similarity:	86/245 - (35%)	Gaps:	66/245 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   356 GKWVEVVIDDRLPTYNGELIYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGGV 420
            |:|..:.||..||..:..........|.:.|.|.:||.:||:..|||.|.||....|::..||.:
Worm    33 GEWKVLKIDFHLPQKSNSFERYAYMVKKQIWVAFIEKGFAKIRKSYEKLSGGVAGIALQQLTGAM 97

  Fly   421 TEWYDIKEAPPNLFSIMMK-------------AAERGSMMGCSLEPDPHVLEAETPQ-----GLI 467
            |            ||:.|:             ...|.|....::.......|:|..|     |:.
Worm    98 T------------FSVFMEKFNNDENRVWEFIQENRNSKFILTVSTPTIEEESEKKQLLEEYGIR 150

  Fly   468 RGHAYSITKVCLMDISTPNRQG-KLPMIRMRNPWGNDAEWSGPWSDSSPEWRFIPEHTKE----- 526
            ..|.||:       :......| :|.::....|:|.        ..|...|..:|.: ||
Worm   151 DCHEYSV-------LDAQVYMGHRLILLAGSGPFGK--------PKSVRRWGHLPSY-KEIREDW 199

  Fly   527 -EIGLNFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQHSSRRKWE 575
             .:.|.|...|.||:...:...:|:.|.:|..             |.||:
Worm   200 CAVDLGFSEFGTFWIDMSELFQYFEYVTVCQY-------------REKWK 236

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042	51/224 (23%)
		Calpain_III	574..721	CDD:279416	1/2 (50%)
		EF-hand_7	759..825	CDD:290234
		EFh	761..826	CDD:298682
		FRQ1	827..>908	CDD:227455
clpr-1	NP_493397.3	CysPc	<28..229	CDD:381776	51/223 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158988
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740