DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CalpB and clp-8

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	NP_493327.2	Gene:	clp-8 / 185746	WormBaseID:	WBGene00009695	Length:	646	Species:	Caenorhabditis elegans

Alignment Length:	383	Identity:	100/383 - (26%)
Similarity:	163/383 - (42%)	Gaps:	67/383 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   202 QEEEPSVGVAEL--SFTSVKVPENQN-MFWMGRKATSARQNSVSKGDFQSLRDSCLANGTMFEDP 263
            ||||    :.||  .:...|...|.| ..::|........|.    .|:|:.:.|..:.:.|.|.
Worm     5 QEEE----LLELIEKYNEDKYCTNMNWTIFLGDHENEKEANE----KFKSILEDCQRSKSAFIDK 61

  Fly   264 DFPATNASLMYSRRPDRYY-------EWLRP----------GDIAD-----DPQFFVEGYSRFDV 306
            :||....|.|......:.|       .||.|          .|::.     :|..|    :.::|
Worm    62 EFPHEPKSYMTFDEQSKVYGKYESWKTWLFPKIWRRITPPSTDVSSSLSVYNPLTF----TAYEV 122

  Fly   307 QQGELGDCWLLAAAANLTQDSTLFFRVIPPDQDFQENYAGIFHFKFWQYGKWVEVVIDDRLPTYN 371
            .|.::|||.|:||.:.::....:...:.   ...|.:..|::..|.:..|:|..::|||..| |.
Worm   123 FQRKVGDCGLVAALSAISTKPEVIMNIF---DSLQLSKYGVYKVKLFVDGQWKTIIIDDYFP-YT 183

  Fly   372 GELIYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGGVTEWYDIKEAPPNL--- 433
            .:.|.:.:|...:.|:||:|||..|..|:|:.:.|..:..|....||.......:.:...||
Worm   184 TDGIRIGATSGYQIWAALIEKALVKECGNYKGIHGFQSLSAFSALTGSPVLLIPVAKMFNNLRKY 248

  Fly   434 FSIMMKAAERGSMMGCSLEPDPHVLEAETPQGLIRGHAYSITKVCLMDISTPNRQGKLPMIRMRN 498
            :..:|:.......|.|.      .|..|. .|::..|||:|     |||  ..|.|. .::.:||
Worm   249 WKTLMEFRNNQYPMACG------TLNREV-NGILPQHAYTI-----MDI--VERDGH-KLLLLRN 298

  Fly   499 PWGNDAEWSGPWSDSSPEWRFIPEHTKEEI-GLNFDRDGEFWMSFQDFLNHFDRVEIC 555
            |.|... |:..|   |.||.:.||:.|:.: |:   ..|.||:|:.||||.|..:.:|
Worm   299 PSGGSV-WTRNW---SKEWEWWPENMKDLLEGM---IRGSFWISWDDFLNVFCSIYVC 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403	8/24 (33%)
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042	86/322 (27%)
		Calpain_III	574..721	CDD:279416
		EF-hand_7	759..825	CDD:290234
		EFh	761..826	CDD:298682
		FRQ1	827..>908	CDD:227455
clp-8	NP_493327.2	CysPc	47..350	CDD:238004	87/333 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158991
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740