DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpB and tra-3

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	NP_502751.1	Gene:	tra-3 / 178385	WormBaseID:	WBGene00006606	Length:	648	Species:	Caenorhabditis elegans

Alignment Length:	515	Identity:	191/515 - (37%)
Similarity:	283/515 - (54%)	Gaps:	66/515 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 DFQSLRDSCLANGTMFEDPDFPATNASLMYSRRPDRYYEWLRPGDIADDPQFFVEGYSRFDVQQG 309
            :::.||..|:.....|.|..||.||.||...:|......|.|||::..||..||||.|..||.||
Worm    14 NYEKLRKICIKKKQPFVDTLFPPTNQSLFLEQRQSSDIVWKRPGELHPDPHLFVEGASPNDVTQG 78

  Fly   310 ELGDCWLLAAAANLTQDSTLFFRVIPPDQDFQE-----NYAGIFHFKFWQYGKWVEVVIDDRLPT 369
            .||:||.::|.:.||.:..|..:|| ||.|.||     .|||||.|:||::||||||||||.|||
Worm    79 ILGNCWFVSACSALTHNFKLLAQVI-PDADDQEWSTKHAYAGIFRFRFWRFGKWVEVVIDDLLPT 142

  Fly   370 YNGELIYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGGVTEWYDIK---EAPP 431
            .:|:|::..|...|||||||||||:|||:|.||.|.||...:|::|.:|||.|...::   :..|
Worm   143 RDGKLLFARSKTPNEFWSALLEKAFAKLYGCYENLVGGHLSDALQDVSGGVAETLHVRKFLKDDP 207

  Fly   432 N-----LFSIMMKAAERGSMMGCSLEP-DPHVLEAETPQGLIRGHAYSITKVCLMDISTPNRQG- 489
            |     ||:.:..|.::|:::..::.. ....:|.....||::||||:::.||.:|::.||.:.
Worm   208 NDTELKLFNDLKTAFDKGALVVAAIAARTKEEIEESLDCGLVKGHAYAVSAVCTIDVTNPNERSF 272

  Fly   490 ---------KLPMIRMRNPWGNDAEWSGPWSDSSPEWRFIPEHTKEEIGL---NFDR-DGEFWMS 541
                     |..:||::|||| :.||:|.|||.||||:.:.......:|:   |.|. ||:|||.
Worm   273 TSFIMGSKRKQNLIRLQNPWG-EKEWNGAWSDDSPEWQNVSASQLSTMGVQPANSDSDDGDFWMP 336

  Fly   542 FQDFLNHFDRVEICNLSPDSLTEDQQHSSRRKWEMSMFEGEWT-----SGV---TAGGCRNFLET 598
            ::.|:::|..:.:|.|...|:     .|..|.::..:...|||     ||.   .||||.||..|
Worm   337 WESFVHYFTDISLCQLFNTSV-----FSFSRSYDEQIVFSEWTTNGKKSGAPDDRAGGCHNFKAT 396

  Fly   599 FWHNPQYIISLEDPDDEDDDGKCTAIVALMQKNRRSKRNVGIDCLTIGFAIYHLTDRDMQVKPQG 663
            |.:|||||..:..|:       |:.:.||:|.:...........:|||..:       |:|:
Worm   397 FCNNPQYIFDIPSPN-------CSVMFALIQNDPSEGLKKREPFVTIGMHV-------MKVE--- 444

  Fly   664 LNFFKYRASVARSP----HFINTREVCARFK-LPPGHYLIVPSTFDPNEEGEFIIRVFSE 718
             |..:||...|..|    .:.:.|.|....: ||.|.||::|:||.|.|:..|::||:|:
Worm   445 -NNRQYRVHTAMHPIAISDYASGRSVYLHLQSLPRGRYLLIPTTFAPKEQTLFMLRVYSD 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042	134/323 (41%)
		Calpain_III	574..721	CDD:279416	49/158 (31%)
		EF-hand_7	759..825	CDD:290234
		EFh	761..826	CDD:298682
		FRQ1	827..>908	CDD:227455
tra-3	NP_502751.1	CysPc	15..361	CDD:128526	141/352 (40%)
		Calpain_III	362..511	CDD:238132	50/160 (31%)
		C2_Calpain	526..646	CDD:176011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820