DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpB and clp-3

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	NP_493052.3	Gene:	clp-3 / 173089	WormBaseID:	WBGene00000544	Length:	752	Species:	Caenorhabditis elegans

Alignment Length:	486	Identity:	204/486 - (41%)
Similarity:	286/486 - (58%)	Gaps:	27/486 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 FQSLRDSCLANGTMFEDPDFPATNASLMYSRRPDRYYEWLRPGDIADDPQFFVEGYSRFDVQQGE 310
            |...|..||....:||||.|||.|:|:....||..:..|.|||::..:|:......:.|||:.|.
Worm   252 FHEERQKCLDEKRLFEDPQFPANNSSIYVKVRPKDHIVWKRPGELFANPRLIGSDKTHFDVKLGR 316

  Fly   311 LGDCWLLAAAANLTQDSTLFFRVIPPDQDFQENYAGIFHFKFWQYGKWVEVVIDDRLPTYNGELI 375
            |.:.|.|:.||||:....||:||:||||.|.|.|||||||:||:||:||:|||||||||.||.|.
Worm   317 LENRWFLSGAANLSLRDELFYRVVPPDQSFTEKYAGIFHFQFWRYGEWVDVVIDDRLPTVNGTLC 381

  Fly   376 YMHSTEKNEFWSALLEKAYAKLHGSYEALKGGTTCEAM----EDFTGGVTEWYDIKEAPP-NLFS 435
            ||.|...:|||..|||||||||.|:||.|....|.:|:    ..||||:|:|:||..|.. .:.:
Worm   382 YMSSPGGSEFWGPLLEKAYAKLLGTYEHLNDPYTEQALWQASASFTGGLTQWFDIFMADEMAVLA 446

  Fly   436 IMMKAAERGSMMGCSLEPDPHVLEAETPQGLIRGHAYSITKVCLMDISTPNRQGKLPMIRMRNPW 500
            ::|:..:.||::.| |..|.:........|||:|:.|.||.|.||:    ....|.|:||:|:||
Worm   447 MIMRGVQMGSLIVC-LNIDVNEKGVRQKNGLIKGYGYCITGVNLME----TEWEKAPLIRIRSPW 506

  Fly   501 GNDAEWSGPWSDSSPEWRFIPEHTKEEIGLNFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTED 565
            |. .:|.|.:...|..|..:.:..:|...:.  .|||||||.:||:..|..|..||||.|::.|.
Worm   507 GK-VKWKGDFCYRSHRWFGLDKEKRESFRIK--EDGEFWMSLKDFMVEFTDVYCCNLSADTMHEV 568

  Fly   566 Q--------QHSSRRKWEMSMFEGEWTSGV-TAGGCRNFLETFWHNPQYIISLEDPDDEDDDGKC 621
            :        :|.| ::|..:.|||||:|.: |||||.:. :||..|.||.|.....|..|.:.||
Worm   569 EKMTEVKVMEHQS-QQWIQASFEGEWSSRIGTAGGCDDH-DTFCTNLQYEIHFRATDSYDSNHKC 631

  Fly   622 TAIVALMQKNRRSKRNVGIDCLTIGFAIYHLTDRDMQVKPQGLNFFKYRASVARSPHFINTREVC 686
            |.|.||.||||......|::...||..:|.:...:.:|.|:   ..|.:..:|.|..|.::||..
Worm   632 TIIAALFQKNRDHCVYKGLELFLIGLLVYEMPGPNEKVTPE---MVKSQTPIADSKLFKDSREAN 693

  Fly   687 ARFKLPPGHYLIVPSTFDPNEEGEFIIRVFS 717
            .||.:|.|||:|||||:||:::|||::|:|:
Worm   694 IRFTVPLGHYVIVPSTYDPDQDGEFLLRIFT 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042	132/300 (44%)
		Calpain_III	574..721	CDD:279416	60/145 (41%)
		EF-hand_7	759..825	CDD:290234
		EFh	761..826	CDD:298682
		FRQ1	827..>908	CDD:227455
clp-3	NP_493052.3	MDN1	<5..136	CDD:227596
		CysPc	254..559	CDD:238004	135/312 (43%)
		Calpain_III	582..732	CDD:238132	60/147 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158987
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2747
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100404
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.660