Protein Alignment CalpB and Capn5

DIOPT Version :9

• Sequence 1: NP_001246706.1
• Gene: CalpB / 39165
• FlyBaseID: FBgn0025866
• Length: 925
• Species: Drosophila melanogaster
• Sequence 2: NP_604456.2
• Gene: Capn5 / 171495
• RGDID: 620084
• Length: 640
• Species: Rattus norvegicus
• Alignment Length: 599
• Identity: 222/599 - (37%)
• Similarity: 325/599 - (54%)
• Gaps: 100/599 - (16%)

  Fly   215 FTSVKVPENQNMFWMGRKATSARQNSVSKGDFQSLRDSCLANGTMFEDPDFPATNASLMYSRRPD 279
            |:..|..|:||                    :.:|:.:||....:||||.||||:.||.|...|.
  Rat     2 FSCTKAYEDQN--------------------YSALKRACLRRKVLFEDPHFPATDDSLYYKGTPG 46

  Fly   280 RYYEWLRPGDIADDPQFFVEGYSRFDVQQGELGDCWLLAAAANLTQDSTLFFRVIP--PDQDFQ- 341
            ....|.||.||.|||:.||:|.|..|:.||::|:||.:||.::|....:|:.:|||  .:|::.
  Rat    47 PTVRWKRPKDICDDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWNP 111

  Fly   342 ---ENYAGIFHFKFWQYGKWVEVVIDDRLPTYNGELIYMHSTEKNEFWSALLEKAYAKLHGSYEA 403
               ::|||||||.||::|:||:||:||||||.|.:|||.||..|||||.||:|||||||.|.|:|
  Rat   112 EKPDSYAGIFHFNFWRFGEWVDVVVDDRLPTVNNQLIYCHSNSKNEFWCALVEKAYAKLAGCYQA 176

  Fly   404 LKGGTTCEAMEDFTGGVTEWYDIKEAP--------PNLFSIMMKAAERGSMMGCSLEPDPHV-LE 459
            |.||.|.:|:.||||||:|..|:.|..        ..||..::|...||.::..|::..... :|
  Rat   177 LDGGNTADALVDFTGGVSEPIDLTEGDLATDEAKRSQLFERVLKVHSRGGLISASIKAMTAADME 241

  Fly   460 AETPQGLIRGHAYSITKVCLMDISTPNRQG----------KLPMIRMRNPWGNDAEWSGPWSDSS 514
            .....||::||||::|.|..:      |.|          ||.|||:||||| :.||:|||||:|
  Rat   242 TRLACGLVKGHAYAVTDVRKV------RLGHGLLAFFKSEKLDMIRLRNPWG-EREWTGPWSDTS 299

  Fly   515 PEWRFIPEHTKEEIGLNFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQHSSRRKWEMSMF 579
            .||:.:.:..:|::|:....||||||:|:|...:|..:..|.|...|..     |..:.||.:..
  Rat   300 EEWQKVSKSEREKMGVTVQDDGEFWMTFEDMCRYFTDIIKCRLINTSYL-----SIHKTWEEARL 359

  Fly   580 EGEWT-----SGVTAGGCRNFLETFWHNPQYIISLEDPDDEDDDGKCTAIVALMQKNRRSKRNVG 639
            .|.||     ....:|||.|..:||:.|||||..::.|:||       .::.:.|:.:||.|..|
  Rat   360 RGAWTRHEDPQQNRSGGCINHKDTFFQNPQYIFEVKKPEDE-------VLICIQQRPKRSTRREG 417

  Fly   640 I-DCLTIGFAIYHLTDRDMQVKPQGLNFFKYRASVARSPHFINTREVCARFKLPPGHYLIVPSTF 703
            . :.|.|||.||.: :.:.|.:...|   :::|:   |..:||:|.|..|.:||.|.|:|:|:||
  Rat   418 KGENLAIGFDIYKV-EENRQYRMHSL---QHKAA---SSIYINSRSVFLRTELPEGRYVIIPTTF 475

  Fly   704 DPNEEGEFIIRVFSETRNNMEE-NDDEVGFGETDDRIAPSLPPPT--------PKEEDDPQRIAL 759
            :|...|||::|||::..:|..| ..||              ||.|        |::......:..
  Rat   476 EPGHTGEFLLRVFTDVPSNCRELRLDE--------------PPRTCWSSLCGYPQQVTQVHVLGA 526

  Fly   760 RRLFDSVAGSDEEV 773
            ..|.||..|::..|
  Rat   527 AGLKDSSTGANSYV 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403	3/9 (33%)
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042	143/320 (45%)
		Calpain_III	574..721	CDD:279416	54/152 (36%)
		EF-hand_7	759..825	CDD:290234	5/15 (33%)
		EFh	761..826	CDD:298682	5/13 (38%)
		FRQ1	827..>908	CDD:227455
Capn5	NP_604456.2	Peptidase_C2	27..341	CDD:279042	143/320 (45%)
		Domain III	344..496		57/170 (34%)
		Calpain_III	354..493	CDD:279416	54/152 (36%)
		C2_Calpain	515..638	CDD:176011	6/26 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920