DRSC/TRiP Functional Genomics Resources

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Protein Alignment CalpB and Capn8

DIOPT Version :10

Sequence 1:NP_524016.4 Gene:CalpB / 39165 FlyBaseID:FBgn0025866 Length:925 Species:Drosophila melanogaster
Sequence 2:NP_570960.2 Gene:Capn8 / 170725 MGIID:2181366 Length:703 Species:Mus musculus


Alignment Length:734 Identity:318/734 - (43%)
Similarity:455/734 - (61%) Gaps:61/734 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly   207 SVGVAELSFTSVKVPENQN-MFWMGRKATSARQNSVSKGDFQSLRDSCLANGTMFEDPDFPATNA 270
            :.|:::....:..:..||| :.::|:             ||::||..||.:|.:|:||:|||..:
Mouse     5 AAGISKQRAAAQGLGSNQNAVKYLGQ-------------DFETLRKQCLNSGVLFKDPEFPACPS 56

  Fly   271 SLMYSRRPDRYYE-----WLRPGDIADDPQFFVEGYSRFDVQQGELGDCWLLAAAANLTQDSTLF 330
            :|.|........|     |.||.::..:|||.|.|.:|.|::||.|||||||||.|:||.:..|.
Mouse    57 ALGYRDLGPGSAETQGIIWKRPTELCSNPQFIVGGATRTDIRQGGLGDCWLLAAIASLTLNEKLL 121

  Fly   331 FRVIPPDQDFQENYAGIFHFKFWQYGKWVEVVIDDRLPTYNGELIYMHSTEKNEFWSALLEKAYA 395
            :||:|.||.||:||||||||:|||||:||||||||||||.||:|:::||.|.|||||||||||||
Mouse   122 YRVVPRDQSFQKNYAGIFHFQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEEGNEFWSALLEKAYA 186

  Fly   396 KLHGSYEALKGGTTCEAMEDFTGGVTEWYDIKEAPPNLFSIMMKAAERGSMMGCSLE-PDPHVLE 459
            ||:||||||.||:|.|..||||||::|:||:::.|.||:..:.||..:||::|||:: .:....|
Mouse   187 KLNGSYEALAGGSTIEGFEDFTGGISEFYDLRKPPGNLYYTIQKALRKGSLLGCSIDVSNAAEAE 251

  Fly   460 AETPQGLIRGHAYSITKVCLMDI-STPNRQGKLPMIRMRNPWGNDAEWSGPWSDSSPEWRFIPEH 523
            |.|.|.|::|||||:|.|..:|. ..|.:     :||:||||| :.||:|.||||:|||.:|...
Mouse   252 ATTRQKLVKGHAYSVTGVEEVDFRGLPEK-----LIRLRNPWG-EVEWTGAWSDSAPEWNYIDPQ 310

  Fly   524 TKEEIGLNFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQHSSRRKWEMSMFEGEWTSGVT 588
            .|.|:....: ||||||||.|||..|.|:||||||||||:.::.|    ||.:.:|.|.||.|.|
Mouse   311 KKGELDKRAE-DGEFWMSFSDFLKQFSRLEICNLSPDSLSSEEIH----KWNLVLFNGRWTRGST 370

  Fly   589 AGGCRNFLETFWHNPQYIISLEDPDDEDDDGK----CTAIVALMQKNRRSKRNVGIDCLTIGFAI 649
            ||||:|:..|:|.|||:.|.|::.|::.::|.    ||.::.|||||||.:|.:|...|:||:|:
Mouse   371 AGGCQNYPATYWTNPQFKIHLDEVDEDQEEGTSEPCCTVLLGLMQKNRRRQRRIGQGMLSIGYAV 435

  Fly   650 YHL-------TDRDMQVKPQGLNFFKYRASVARSPHFINTREVCARFKLPPGHYLIVPSTFDPNE 707
            |.:       ||..:     |.:||:.|.....|..::|.|||.:|.:||||.||:|||||:|.:
Mouse   436 YQIPKELENHTDEHL-----GRDFFQGRQPSTCSSTYMNLREVSSRVQLPPGQYLVVPSTFEPFK 495

  Fly   708 EGEFIIRVFSETRNNMEENDDEVGFGETDDRIAPSLPPPTPKEEDDPQRIALRRLFDSVAGSDEE 772
            :|:|.:|||||.:....|..|.|. |:      |..|.|...:.:|....:|...|   |..|.|
Mouse   496 DGDFCLRVFSEKKAQALEIGDAVA-GD------PHEPHPRDMDGEDEHFWSLSEEF---ADKDSE 550

  Fly   773 VDWQELKRILDH--SMRDVMVGSDGFSKDAVRSMVAMLDKDRSGRLGFEEFEALLTDIAKWRAVF 835
            :...:|||:|:.  |.|..| ..|||:.:..|.|:::||.|.:|.|...||:.|...|.|:..::
Mouse   551 ISAHQLKRVLNGLLSKRTDM-KFDGFNINTCREMISLLDGDGTGSLRPVEFKTLWLKICKYLEIY 614

  Fly   836 KLYDTRRTGSIDGFHLRGALNSAGYHLNNRLLNALAHRYGSREGQIPFDDFLMCAIKVRTFIEMF 900
            :..|..|.|:||...:|.||..||:.|||::...:|.||...:..:.||.|:.|.|::....::|
Mouse   615 QEMDHSRAGTIDAHEMRTALKKAGFTLNNQVQQTIATRYACSKLGVDFDGFVACMIRLEILFKLF 679

  Fly   901 RERDTDNSDTAFFNLDDWL 919
            |..|.|.:.....:|.:||
Mouse   680 RLLDKDQNGIVQLSLAEWL 698

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpBNP_524016.4 PHA03247 <40..207 CDD:223021 318/734 (43%)
Peptidase_C2 260..556 CDD:459889 165/302 (55%)
Calpain_III 579..716 CDD:460050 63/147 (43%)
EFh_PEF_CalpA_B 758..925 CDD:320071 55/164 (34%)
EF-hand motif 758..786 CDD:320071 9/29 (31%)
EF-hand motif 799..829 CDD:320071 10/29 (34%)
EF-hand motif 830..860 CDD:320071 10/29 (34%)
EF-hand motif 866..894 CDD:320071 8/27 (30%)
EF-hand motif 895..925 CDD:320071 7/25 (28%)
Capn8NP_570960.2 Peptidase_C2 46..342 CDD:459889 165/302 (55%)
Calpain_III 354..514 CDD:238132 70/168 (42%)
Domain III 355..512 69/161 (43%)
Linker. /evidence=ECO:0000250 513..531 7/24 (29%)
Domain IV. /evidence=ECO:0000250 532..703 56/171 (33%)
EFh_PEF 537..703 CDD:355382 55/166 (33%)
EF-hand motif 537..564 CDD:320054 9/29 (31%)
EF-hand motif 579..608 CDD:320054 10/28 (36%)
EF-hand motif 609..638 CDD:320054 9/28 (32%)
EF-hand motif 645..673 CDD:320054 8/27 (30%)
EF-hand motif 675..703 CDD:320054 7/24 (29%)

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