DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpB and CAPN12

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	XP_016881844.1	Gene:	CAPN12 / 147968	HGNCID:	13249	Length:	723	Species:	Homo sapiens

Alignment Length:	756	Identity:	261/756 - (34%)
Similarity:	379/756 - (50%)	Gaps:	151/756 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 EEEPSVGVAELSFTSVKVPENQNMFWMGRKATSARQNSVSKGDFQSLRDSCLANGTMFEDPDFPA 267
            :||..||...|            ..:.|:             .::::|.:||.:|.:|.||.|||
Human    14 DEEAGVGAGRL------------QLFRGQ-------------SYEAIRAACLDSGILFRDPYFPA 53

  Fly   268 TNASLMYSR-RPD----RYYEWLRPGDIADDPQFFVEGYSRFDVQQGELGDCWLLAAAANLTQDS 327
            ...:|.|.: .||    :..:|:||.:...:|:|..|..||.||.||.||:||.|||||:||...
Human    54 GPDALGYDQLGPDSEKAKGVKWMRPHEFCAEPKFICEDMSRTDVCQGSLGNCWFLAAAASLTLYP 118

  Fly   328 TLFFRVIPPDQDFQENYAGIFHFKFWQYGKWVEVVIDDRLPTYNGELIYMHSTEKNEFWSALLEK 392
            .|..||:||.||||..|||:|||:.||:|:|::||:|||||...|:|:::.|.::||||:.||||
Human   119 RLLRRVVPPGQDFQHGYAGVFHFQLWQFGRWMDVVVDDRLPVREGKLMFVRSEQRNEFWAPLLEK 183

  Fly   393 AYAKLHGSYEALKGGTTCEAMEDFTGGVTEWYDIKEAPPNLFSIMMKAAERGSMMGCSLEPDPHV 457
            ||||||||||.::||...||..||||||.|...:::....|||.:..|..:.|::|.:...|..
Human   184 AYAKLHGSYEVMRGGHMNEAFVDFTGGVGEVLYLRQNSMGLFSALRHALAKESLVGATALSDRG- 247

  Fly   458 LEAETPQGLIRGHAYSIT---KVCLMDISTPNRQG--KLPMIRMRNPWGNDAEWSGPWSDSSPEW 517
             |..|.:||::|||||||   ||.|         |  |:.::|:||||| ..||:|.||||.|.|
Human   248 -EYRTEEGLVKGHAYSITGTHKVFL---------GFTKVRLLRLRNPWG-CVEWTGAWSDSCPRW 301

  Fly   518 RFIPEHTKEEIGLNFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQHSSRRKWEMSMFEGE 582
            ..:|...::.: |....||||||..:|||.|||.|:||:|||:.|....:...   |.:..|:|.
Human   302 DTLPTECRDAL-LVKKEDGEFWMELRDFLLHFDTVQICSLSPEVLGPSPEGGG---WHVHTFQGR 362

  Fly   583 WTSGVTAGGCRNFLETFWHNPQYIISLEDPDDEDDDG-----------------------KCTAI 624
            |..|..:||.:...||||.|||:.::|.:||:|||:.                       |||.:
Human   363 WVRGFNSGGSQPNAETFWTNPQFRLTLLEPDEEDDEDEEGPWGGWGAAGARGPARGGRTPKCTVL 427

  Fly   625 VALMQKNRRSKRNVGIDCLTIGFAIYHLTDRDMQVKPQGLNFFKYRASVARSPHFINT------- 682
            ::|:|:|||..|..|:..||:||.::       |:..:.|..:....|.|..|..:..
Human   428 LSLIQRNRRRLRAKGLTYLTVGFHVF-------QIPEELLGLWDSPRSHALLPRLLRADRSPLSA 485

  Fly   683 -REVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETRNNMEENDDEVGFGETDDRIAPSLPP- 745
             |:|..|..|.|||||:||||....:|.:|.:|||||.|:.       .|....|.| .|::.|
Human   486 RRDVTRRCCLRPGHYLVVPSTAHAGDEADFTLRVFSERRHT-------AGDRRRDQR-RPAVSPG 542

  Fly   746 --------------------------PTPKEEDDPQRIALRRLFDSVAGSDEEVDWQELKRILDH 784
                                      |.|..              .|..:.....|    |...|
Human   543 GDCSWRGGMGRGSWPALNFRHAAGPLPAPGA--------------GVGAAVSGAGW----RARAH 589

  Fly   785 SMRDVMVGSDGFSKDAVRSMVAMLDKDRSGR-LGFEEFEALLTDIAKWRAVFKLYDTRRTGSIDG 848
            :.....:|        :|:...:|.....|: |....|:.|...:.:|:|:|..:|...:|:::.
Human   590 TSTPREIG--------LRTCEQLLQCFGHGQSLALHHFQQLWGYLLEWQAIFNKFDEDTSGTMNS 646

  Fly   849 FHLRGALNSAGYHLNNRLLNALAHRYGSREGQIPFDDFLMC 889
            :.||.|||:||:||||:|...|..||.....::.|:.|:.|
Human   647 YELRLALNAAGFHLNNQLTQTLTSRYRDSRLRVDFERFVSC 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403	5/21 (24%)
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042	145/305 (48%)
		Calpain_III	574..721	CDD:279416	59/177 (33%)
		EF-hand_7	759..825	CDD:290234	10/66 (15%)
		EFh	761..826	CDD:298682	11/65 (17%)
		FRQ1	827..>908	CDD:227455	23/63 (37%)
CAPN12	XP_016881844.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920