DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpB and Capn7

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	NP_033926.1	Gene:	Capn7 / 12339	MGIID:	1338030	Length:	813	Species:	Mus musculus

Alignment Length:	721	Identity:	150/721 - (20%)
Similarity:	247/721 - (34%)	Gaps:	273/721 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 TSPAPQHNIGFPALPYPTAPPPESAPTQEEEPSVGVAELSFTSVKVPENQNMFWMGRKATSARQN 239
            |.|...|   ||..|.|....|:                :|.|.:..:.|     |:|.|:.
Mouse   170 TPPVRTH---FPLGPNPFVEKPQ----------------AFISPQSCDAQ-----GQKYTAE--- 207

  Fly   240 SVSKGDFQSLRDSCLANGTMFEDPDFPATNASL------------------MYSRRPDRYYEWLR 286
                 :.:.||.:...||..:    .|..:..|                  :..::...:.:|:|
Mouse   208 -----EIEVLRTTSKINGVEY----VPFMSVDLRERFAYPMPFCDRLGKLPLSPKQKTTFSKWVR 263

  Fly   287 PGDIADDPQFFVEGYSRFDVQQGELGDCWLLAAAANLTQDSTLFFR------VIPPDQDFQENY- 344
            |.|:.::|. .:...|.|.::|..:.||..:|:.|........|.:      :.|.::|.:..|
Mouse   264 PEDLTNNPT-MIYTVSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLITSIIYPQNKDGEPEYN 327

  Fly   345 -AGIFHFKFWQYGKWVEVVIDDRLPT-YNGELIYMHSTEKNEFWSALLEKAYAKLHGSYEALKGG 407
             .|.:..|....|...:|:|||:||. :.|||:..:|..|:|.|.:|:||||.|:.|.|: ..|.
Mouse   328 PCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVSLIEKAYMKVMGGYD-FPGS 391

  Fly   408 TTCEAMEDFTGGVTEWYDIKE-----APPNLFSIMMKAAERGSMMGCSLEPDPHVL-EAETPQ-G 465
            .:...:...||.:.|...:..     :..|.|.::.:...:|.::   :.....|: |||..: |
Mouse   392 NSNIDLHALTGWIPERIAMHSDSQTFSKDNSFRMLYQRFHKGDVL---ITASTGVMTEAEGEKWG 453

  Fly   466 LIRGHAYSITKVCLMDISTPNRQGK-LPMIRMRNPWGNDAEWSGPWSDSSPEWRFIPEHTKEEIG 529
            |:..|||::     :||    |:.| |..|:::|||.: ..|.|.:|::..: .:.||..|.
Mouse   454 LVPTHAYAV-----LDI----REFKGLRFIQLKNPWSH-LRWKGRYSENDVK-NWTPELQKY--- 504

  Fly   530 LNFD-------RDGEFWMSFQDFLNHFDRV----------------------------------- 552
            ||||       .:|.||:|:.|...::|.|
Mouse   505 LNFDPRTAQKIDNGIFWISWDDLCQYYDVVYLSWNPALFKESTCIHSTWDAKQGPVKDAYSLANN 569

  Fly   553 ----------------------------------EICNL-------------------------- 557
                                              |...:
Mouse   570 PQYKLEVQCPQGGAAVWVLLSRHITDKDDFANNREFITMVVYKTDGKKVYYPADPPPYIDGIRIN 634

  Fly   558 SPDSLT-------------------EDQQ--HSSRRKWEMSMF---------------EGEWTSG 586
            ||..||                   |.|.  |.:.|.:....|               .|:| ||
Mouse   635 SPHYLTKIKLTTPGTHTFTLVVSQYEKQNTIHYTVRVYSACSFTFSKIPSPYTLSKRINGKW-SG 698

  Fly   587 VTAGGCRNFLETFWHNPQYIISLEDPDDEDDDGKCTAIVALMQKNRRSKRNVGIDCLTI------ 645
            .:||||.||.||..:||.|...:      |..|.     .|::.....:.:||.:.:.:
Mouse   699 QSAGGCGNFQETHKNNPIYQFHI------DKTGP-----LLIELRGPRQYSVGFEVVAVSIMGDP 752

  Fly   646 ---GFAIYHLTDRDMQVKPQGLNFFKYRASVARSPHFINTREVCARFKLPPGHYLIVPSTFDPNE 707
               ||          |.|..|    .||....    ::....:      |.|.:.|:||||.|.:
Mouse   753 GPHGF----------QRKSSG----DYRCGFC----YLELENI------PAGIFNIIPSTFLPKQ 793

  Fly   708 EGEFII 713
            ||.|.:
Mouse   794 EGPFFL 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403	10/49 (20%)
		Drf_FH1	37..189	CDD:283903	5/13 (38%)
		Peptidase_C2	260..556	CDD:279042	85/406 (21%)
		Calpain_III	574..721	CDD:279416	39/164 (24%)
		EF-hand_7	759..825	CDD:290234
		EFh	761..826	CDD:298682
		FRQ1	827..>908	CDD:227455
Capn7	NP_033926.1	MIT_calpain7_1	5..76	CDD:239144
		MIT	85..157	CDD:294211
		CysPc	214..538	CDD:238004	86/346 (25%)
		Domain III	541..701		14/160 (9%)
		calpain_III	687..810	CDD:214786	38/149 (26%)
		Domain N	702..813		33/133 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810