Protein Alignment CalpB and Capn7

DIOPT Version :10

• Sequence 1: NP_524016.4
• Gene: CalpB / 39165
• FlyBaseID: FBgn0025866
• Length: 925
• Species: Drosophila melanogaster
• Sequence 2: NP_033926.1
• Gene: Capn7 / 12339
• MGIID: 1338030
• Length: 813
• Species: Mus musculus
• Alignment Length: 721
• Identity: 150/721 - (20%)
• Similarity: 247/721 - (34%)
• Gaps: 273/721 - (37%)

  Fly   175 TSPAPQHNIGFPALPYPTAPPPESAPTQEEEPSVGVAELSFTSVKVPENQNMFWMGRKATSARQN 239
            |.|...|   ||..|.|....|:                :|.|.:..:.|     |:|.|:.
Mouse   170 TPPVRTH---FPLGPNPFVEKPQ----------------AFISPQSCDAQ-----GQKYTAE--- 207

  Fly   240 SVSKGDFQSLRDSCLANGTMFEDPDFPATNASL------------------MYSRRPDRYYEWLR 286
                 :.:.||.:...||..:    .|..:..|                  :..::...:.:|:|
Mouse   208 -----EIEVLRTTSKINGVEY----VPFMSVDLRERFAYPMPFCDRLGKLPLSPKQKTTFSKWVR 263

  Fly   287 PGDIADDPQFFVEGYSRFDVQQGELGDCWLLAAAANLTQDSTLFFR------VIPPDQDFQENY- 344
            |.|:.::|. .:...|.|.::|..:.||..:|:.|........|.:      :.|.::|.:..|
Mouse   264 PEDLTNNPT-MIYTVSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLITSIIYPQNKDGEPEYN 327

  Fly   345 -AGIFHFKFWQYGKWVEVVIDDRLPT-YNGELIYMHSTEKNEFWSALLEKAYAKLHGSYEALKGG 407
             .|.:..|....|...:|:|||:||. :.|||:..:|..|:|.|.:|:||||.|:.|.|: ..|.
Mouse   328 PCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVSLIEKAYMKVMGGYD-FPGS 391

  Fly   408 TTCEAMEDFTGGVTEWYDIKE-----APPNLFSIMMKAAERGSMMGCSLEPDPHVL-EAETPQ-G 465
            .:...:...||.:.|...:..     :..|.|.::.:...:|.::   :.....|: |||..: |
Mouse   392 NSNIDLHALTGWIPERIAMHSDSQTFSKDNSFRMLYQRFHKGDVL---ITASTGVMTEAEGEKWG 453

  Fly   466 LIRGHAYSITKVCLMDISTPNRQGK-LPMIRMRNPWGNDAEWSGPWSDSSPEWRFIPEHTKEEIG 529
            |:..|||::     :||    |:.| |..|:::|||.: ..|.|.:|::..: .:.||..|.
Mouse   454 LVPTHAYAV-----LDI----REFKGLRFIQLKNPWSH-LRWKGRYSENDVK-NWTPELQKY--- 504

  Fly   530 LNFD-------RDGEFWMSFQDFLNHFDRV----------------------------------- 552
            ||||       .:|.||:|:.|...::|.|
Mouse   505 LNFDPRTAQKIDNGIFWISWDDLCQYYDVVYLSWNPALFKESTCIHSTWDAKQGPVKDAYSLANN 569

  Fly   553 ----------------------------------EICNL-------------------------- 557
                                              |...:
Mouse   570 PQYKLEVQCPQGGAAVWVLLSRHITDKDDFANNREFITMVVYKTDGKKVYYPADPPPYIDGIRIN 634

  Fly   558 SPDSLT-------------------EDQQ--HSSRRKWEMSMF---------------EGEWTSG 586
            ||..||                   |.|.  |.:.|.:....|               .|:| ||
Mouse   635 SPHYLTKIKLTTPGTHTFTLVVSQYEKQNTIHYTVRVYSACSFTFSKIPSPYTLSKRINGKW-SG 698

  Fly   587 VTAGGCRNFLETFWHNPQYIISLEDPDDEDDDGKCTAIVALMQKNRRSKRNVGIDCLTI------ 645
            .:||||.||.||..:||.|...:      |..|.     .|::.....:.:||.:.:.:
Mouse   699 QSAGGCGNFQETHKNNPIYQFHI------DKTGP-----LLIELRGPRQYSVGFEVVAVSIMGDP 752

  Fly   646 ---GFAIYHLTDRDMQVKPQGLNFFKYRASVARSPHFINTREVCARFKLPPGHYLIVPSTFDPNE 707
               ||          |.|..|    .||....    ::....:      |.|.:.|:||||.|.:
Mouse   753 GPHGF----------QRKSSG----DYRCGFC----YLELENI------PAGIFNIIPSTFLPKQ 793

  Fly   708 EGEFII 713
            ||.|.:
Mouse   794 EGPFFL 799

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_524016.4	PHA03247	<40..207	CDD:223021	8/31 (26%)
		Peptidase_C2	260..556	CDD:459889	85/406 (21%)
		Calpain_III	579..716	CDD:460050	39/159 (25%)
		EFh_PEF_CalpA_B	758..925	CDD:320071
		EF-hand motif	758..786	CDD:320071
		EF-hand motif	799..829	CDD:320071
		EF-hand motif	830..860	CDD:320071
		EF-hand motif	866..894	CDD:320071
		EF-hand motif	895..925	CDD:320071
Capn7	NP_033926.1	MIT_calpain7_1	5..76	CDD:239144
		MIT	85..157	CDD:469712
		CysPc	214..538	CDD:238004	86/346 (25%)
		Domain III	541..701		14/160 (9%)
		calpain_III	687..810	CDD:214786	38/149 (26%)
		Domain N	702..813		33/133 (25%)