DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpB and Capn6

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	NP_031629.3	Gene:	Capn6 / 12338	MGIID:	1100850	Length:	641	Species:	Mus musculus

Alignment Length:	508	Identity:	182/508 - (35%)
Similarity:	275/508 - (54%)	Gaps:	52/508 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 FQSLRDSCLANGTMFEDPDFPATNASLMYSRRPDRYYEWLRPGDIADDPQFFVEGYSRFDVQQGE 310
            :|.|:..|:.:|.:|.||.|...|.||.::|.......|.||.||:|||...|...|...:.||.
Mouse    13 YQELKQECMKDGRLFCDPTFLPENDSLFFNRLLPGKVVWKRPQDISDDPHLIVGNISNHQLIQGR 77

  Fly   311 LGDCWLLAAAANLTQDSTLFFRVIP--PDQDFQ----ENYAGIFHFKFWQYGKWVEVVIDDRLPT 369
            ||:..:::|.:.|....:.:.:.||  .||::.    |.|||||||:||.:|:|.||||||.|||
Mouse    78 LGNKAMISAFSCLAVQESHWTKAIPNHKDQEWDPRKPEKYAGIFHFRFWHFGEWTEVVIDDLLPT 142

  Fly   370 YNGELIYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGGVTE--------WYDI 426
            .||:|::..||..||||:||||||||||.|.||||.|.|..:.:.||||.:.|        :.|:
Mouse   143 INGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTITDIIMDFTGTLAEIIDMQKGRYTDL 207

  Fly   427 KEAPPNLFSIMMKAAERGSMMGCSLE-PDPHVLEAETPQGLIRGHAYSITKV-------CLMDIS 483
            .|....||..:.|...:|.::.||:| |.....|.||..||::|:.|::|.:       .|:::.
Mouse   208 VEEKYKLFGELYKTFTKGGLICCSIESPSQEEQEVETDWGLLKGYTYTMTDIRKLRLGERLVEVF 272

  Fly   484 TPNRQGKLPMIRMRNPWGNDAEWSGPWSDSSPEWRFIPEHTKEEIGLNFDRDGEFWMSFQDFLNH 548
            :..   ||.|:|:|||.|.. |||||||:.|.||:.:....::.:||....|||||||.:||.::
Mouse   273 STE---KLYMVRLRNPLGRQ-EWSGPWSEISEEWQQLTVTDRKNLGLVMSDDGEFWMSLEDFCHN 333

  Fly   549 FDRVEICNLSPDSLTEDQQHSSRRKWEMSMFEGEWTSG-----VTAGGCRNFLETFWHNPQYIIS 608
            |.::.:|        .:..:....:.|:....|.||..     ..:|||.|..:||..|||||.:
Mouse   334 FHKLNVC--------RNVNNPVFGRKELESVVGCWTVDDDPLMNRSGGCYNNRDTFLQNPQYIFT 390

  Fly   609 LEDPDDEDDDGKCTAIVALMQKNRRSKRNVG-IDCLTIGFAIYHLTDRDMQVKPQGLNFFKYRAS 672
            :      .:||. ..|::|.||:.|:.|.:| .|...|||.::.: :.:.:.:...| :.:.||.
Mouse   391 V------PEDGH-KVIMSLQQKDLRTYRRMGRPDNYIIGFELFKV-EMNRRFRLHHL-YIQERAG 446

  Fly   673 VARSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETRNNMEE 725
            .:.   :|:||.|.....|..|.|::||:.|......||::|:|||....:.|
Mouse   447 TST---YIDTRTVFLSKYLKKGSYVLVPTMFQHGRTSEFLLRIFSEVPVQLRE 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042	129/317 (41%)
		Calpain_III	574..721	CDD:279416	47/152 (31%)
		EF-hand_7	759..825	CDD:290234
		EFh	761..826	CDD:298682
		FRQ1	827..>908	CDD:227455
Capn6	NP_031629.3	CysPc	13..351	CDD:128526	134/349 (38%)
		Domain III	344..495		47/162 (29%)
		Calpain_III	349..497	CDD:238132	48/160 (30%)
		C2_Calpain	514..639	CDD:176011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820