Protein Alignment CalpB and Capn5

DIOPT Version :9

• Sequence 1: NP_001246706.1
• Gene: CalpB / 39165
• FlyBaseID: FBgn0025866
• Length: 925
• Species: Drosophila melanogaster
• Sequence 2: XP_006507338.1
• Gene: Capn5 / 12337
• MGIID: 1100859
• Length: 653
• Species: Mus musculus
• Alignment Length: 608
• Identity: 225/608 - (37%)
• Similarity: 332/608 - (54%)
• Gaps: 100/608 - (16%)

  Fly   206 PSVGVAELSFTSVKVPENQNMFWMGRKATSARQNSVSKGDFQSLRDSCLANGTMFEDPDFPATNA 270
            |.:|.....|:..|..|:||                    :.:|:.:||....:||||.||||:.
Mouse     6 PLLGDVVTMFSCAKAYEDQN--------------------YSALKRACLRKKVLFEDPLFPATDD 50

  Fly   271 SLMYSRRPDRYYEWLRPGDIADDPQFFVEGYSRFDVQQGELGDCWLLAAAANLTQDSTLFFRVIP 335
            ||.|...|.....|.||.||.|||:.||:|.|..|:.||::|:||.:||.::|....:|:.:|||
Mouse    51 SLYYKGTPGPTVRWKRPKDICDDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIP 115

  Fly   336 --PDQDFQ----ENYAGIFHFKFWQYGKWVEVVIDDRLPTYNGELIYMHSTEKNEFWSALLEKAY 394
              .:|::.    ::|||||||.||::|:||:|::||||||.|.:|||.||..|||||.||:||||
Mouse   116 DWKEQEWNPEKPDSYAGIFHFNFWRFGEWVDVIVDDRLPTVNNQLIYCHSNSKNEFWCALVEKAY 180

  Fly   395 AKLHGSYEALKGGTTCEAMEDFTGGVTEWYDI-------KEAPPN-LFSIMMKAAERGSMMGCSL 451
            |||.|.|:||.||.|.:|:.||||||:|..|:       .||..| ||..::|...||.::..|:
Mouse   181 AKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGDLATDEAKRNQLFERVLKVHSRGGLISASI 245

  Fly   452 EPDPHV-LEAETPQGLIRGHAYSITKVCLMDISTPNRQG----------KLPMIRMRNPWGNDAE 505
            :..... :||....||::||||::|.|..:      |.|          ||.|||:||||| :.|
Mouse   246 KAVTAADMEARLACGLVKGHAYAVTDVRKV------RLGHGLLAFFKSEKLDMIRLRNPWG-ERE 303

  Fly   506 WSGPWSDSSPEWRFIPEHTKEEIGLNFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQHSS 570
            |:|||||:|.||:.:.:..:|::|:....||||||:|:|...:|..:..|.|...|..     |.
Mouse   304 WTGPWSDTSEEWQKVSKSEREKMGVTVQDDGEFWMTFEDMCRYFTDIIKCRLINTSYL-----SI 363

  Fly   571 RRKWEMSMFEGEWT-----SGVTAGGCRNFLETFWHNPQYIISLEDPDDEDDDGKCTAIVALMQK 630
            .:.||.:...|.||     ....:|||.|..:||:.||||:..::.|:||       .::::.|:
Mouse   364 HKTWEEARLHGAWTRHEDPQQNRSGGCINHKDTFFQNPQYVFEVKKPEDE-------VLISIQQR 421

  Fly   631 NRRSKRNVGI-DCLTIGFAIYHLTDRDMQVKPQGLNFFKYRASVARSPHFINTREVCARFKLPPG 694
            .:||.|..|. :.|.|||.||.: :.:.|.:...|   :::|:   |..:||:|.|..|.:||.|
Mouse   422 PKRSTRREGKGENLAIGFDIYKV-EENRQYRMHSL---QHKAA---SSIYINSRSVFLRTELPEG 479

  Fly   695 HYLIVPSTFDPNEEGEFIIRVFSETRNNMEE-NDDEVGFGETDDRIAPSLPPPT--------PKE 750
            .|:|:|:||:|...|||::|||::..:|..| ..||              ||.|        |::
Mouse   480 RYVIIPTTFEPGHTGEFLLRVFTDVPSNCRELRLDE--------------PPRTCWSSLCGYPQQ 530

  Fly   751 EDDPQRIALRRLFDSVAGSDEEV 773
            ......:....|.||..|::..|
Mouse   531 VAQVHVLGAAGLKDSPTGANSYV 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403	5/18 (28%)
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042	145/320 (45%)
		Calpain_III	574..721	CDD:279416	53/152 (35%)
		EF-hand_7	759..825	CDD:290234	5/15 (33%)
		EFh	761..826	CDD:298682	5/13 (38%)
		FRQ1	827..>908	CDD:227455
Capn5	XP_006507338.1	Peptidase_C2	40..354	CDD:366222	145/320 (45%)
		Calpain_III	365..511	CDD:238132	54/159 (34%)
		C2_Calpain	528..651	CDD:176011	6/26 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820