DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CalpB and Capn3

DIOPT Version :9

Sequence 1:NP_001246706.1 Gene:CalpB / 39165 FlyBaseID:FBgn0025866 Length:925 Species:Drosophila melanogaster
Sequence 2:NP_031627.2 Gene:Capn3 / 12335 MGIID:107437 Length:821 Species:Mus musculus


Alignment Length:879 Identity:348/879 - (39%)
Similarity:484/879 - (55%) Gaps:157/879 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   146 LPYPAAP-LAPYPSAMPGLPGMPMPY-APMPTSPAPQHNIGFPALPYPTAPPPESAPTQEEEPSV 208
            :|...:| :||...|.|..|| |:|: |...|:.|   ..|.|:..|       ||......|.:
Mouse     1 MPTVISPTVAPRTGAEPRSPG-PVPHPAQGKTTEA---GGGHPSGIY-------SAIISRNFPII 54

  Fly   209 GVAELSFTSVKVPENQNMFWMGRKATSARQNSVSKGDFQSLRDSCLANGTMFEDPDFPATNASLM 273
            ||.|.:                               |:.||..||....::.||:||....||.
Mouse    55 GVKEKT-------------------------------FEQLRRKCLEKKVLYLDPEFPPDETSLF 88

  Fly   274 YSRRPDRYYEWLRPGDIADDPQFFVEGYSRFDVQQGELGDCWLLAAAANLTQDSTLFFRVIPPDQ 338
            ||::....:.|.||.:|.::|:|.:.|.:|.|:.||:|||||.|||.|.||.:..|.|||||.||
Mouse    89 YSQKFPIQFVWKRPPEICENPRFIIGGANRTDICQGDLGDCWFLAAIACLTLNERLLFRVIPHDQ 153

  Fly   339 DFQENYAGIFHFKFWQYGKWVEVVIDDRLPTYNGELIYMHSTEKNEFWSALLEKAYAKLHGSYEA 403
            .|.|||||||||:||:||.||:|||||.|||||.:|::..|..:|||||||||||||||||||||
Mouse   154 SFTENYAGIFHFQFWRYGDWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEA 218

  Fly   404 LKGGTTCEAMEDFTGGVTEWYDIKEAPPNLFSIMMKAAERGSMMGCSLEPDPHVLEAETPQ---- 464
            ||||.|.||||||||||||:::||:||.:::.||.||.||||:||||::...::....:|.    
Mouse   219 LKGGNTTEAMEDFTGGVTEFFEIKDAPSDMYKIMRKAIERGSLMGCSIDDGTNMTYGTSPSGLNM 283

  Fly   465 ---------------------------------------------GLIRGHAYSIT--KVCLMDI 482
                                                         ||::|||||:|  :..|.  
Mouse   284 GELIARMVRNMDNSLLRDSDLDPRGSDDRPSRTIVPVQYETRMACGLVKGHAYSVTGLEEALF-- 346

  Fly   483 STPNRQGKLPMIRMRNPWGNDAEWSGPWSDSSPEWRFIPEHTKEEIGLNFDRDGEFWMSFQDFLN 547
                :..|:.::|:||||| ..||:|.|||...:|.|:.:..|..:......|||||||:.||:.
Mouse   347 ----KGEKVKLVRLRNPWG-QVEWNGSWSDGWKDWSFVDKDEKARLQHQVTEDGEFWMSYDDFVY 406

  Fly   548 HFDRVEICNLSPDSLTEDQQHSSRRKWEMSMFEGEWTSGVTAGGCRNFLETFWHNPQYIISL--E 610
            ||.::|||||:.|:|..|:..:    |.:|:.||.|..|.:|||||||.:|||.||||.:.|  |
Mouse   407 HFTKLEICNLTADALESDKLQT----WTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEE 467

  Fly   611 DPDDEDDDGKCTAIVALMQKNRRSKRNVGIDCLTIGFAIYHLTDRDMQVKPQGL--NFFKYRASV 673
            |.|.||.:..|:.:|||||||||..|.:|.:..|||||||.: .::|....|.|  :||.|.||.
Mouse   468 DDDPEDSEVICSFLVALMQKNRRKDRKLGANLFTIGFAIYEV-PKEMHGNKQHLQKDFFLYNASK 531

  Fly   674 ARSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETRNNMEE------------- 725
            |||..:||.|||..||:|||..|:|||||::|::|||||:|||||.||..||             
Mouse   532 ARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEAENTISVDRPVKK 596

  Fly   726 --------------NDDEVGFG----ETDDRIAP----SLPPPTP----KEEDDPQRIALRRLFD 764
                          ::.|:|..    |..|:..|    ..|.|.|    :|.::.|:  .|.:|.
Mouse   597 KKNKPIIFVSDRANSNKELGVDQEAEEGKDKAGPEKRGETPQPRPGHTDQESEEQQQ--FRNIFR 659

  Fly   765 SVAGSDEEVDWQELKRILD---HSMRDVMVGSDGFSKDAVRSMVAMLDKDRSGRLGFEEFEALLT 826
            .:||.|.|:...|||.:|:   :..:|:.  :.||:.::.|||:|::|.|.||||..:||..|..
Mouse   660 QIAGDDMEICADELKNVLNTVVNKHKDLK--TQGFTLESCRSMIALMDTDGSGRLNLQEFHHLWK 722

  Fly   827 DIAKWRAVFKLYDTRRTGSIDGFHLRGALNSAGYHLNNRLLNALAHRYGSREGQIPFDDFLMCAI 891
            .|..|:.:||.|||..:|:|:.:.:|.|:|.||:|||::|.:.:..||..:...|.||.|:.|.:
Mouse   723 KIKAWQKIFKHYDTDHSGTINSYEMRNAVNDAGFHLNSQLYDIITMRYADKHMNIDFDSFICCFV 787

  Fly   892 KVRTFIEMFRERDTDNSDTAFFNLDDWLERTIYS 925
            ::......|...|.|.......|:.:||:.|:|:
Mouse   788 RLEGMFRAFNAFDKDGDGIIKLNVLEWLQLTMYA 821

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpBNP_001246706.1 PD-C2-AF1 33..225 CDD:286403 22/80 (28%)
Drf_FH1 37..189 CDD:283903 15/44 (34%)
Peptidase_C2 260..556 CDD:279042 159/346 (46%)
Calpain_III 574..721 CDD:279416 83/150 (55%)
EF-hand_7 759..825 CDD:290234 25/68 (37%)
EFh 761..826 CDD:298682 25/67 (37%)
FRQ1 827..>908 CDD:227455 28/80 (35%)
Capn3NP_031627.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..37 13/39 (33%)
Peptidase_C2 77..415 CDD:279042 159/344 (46%)
Domain III 418..586 90/172 (52%)
Calpain_III 429..579 CDD:279416 83/150 (55%)
Calpain_u2 583..653 CDD:293254 10/69 (14%)
Linker 587..649 9/61 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 603..651 9/47 (19%)
Domain IV 650..820 59/173 (34%)
EFh 653..722 CDD:238008 26/72 (36%)
EFh 697..751 CDD:238008 23/53 (43%)
EFh 728..817 CDD:298682 29/88 (33%)
EF-hand_7 728..784 CDD:290234 22/55 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 357 1.000 Domainoid score I968
eggNOG 1 0.900 - - E1_KOG0045
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 640 1.000 Inparanoid score I814
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48339
OrthoDB 1 1.010 - - D704215at2759
OrthoFinder 1 1.000 - - FOG0000071
OrthoInspector 1 1.000 - - mtm8819
orthoMCL 1 0.900 - - OOG6_100404
Panther 1 1.100 - - LDO PTHR10183
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X74
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1312.880

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