Protein Alignment CalpB and CAPN10

DIOPT Version :9

• Sequence 1: NP_001246706.1
• Gene: CalpB / 39165
• FlyBaseID: FBgn0025866
• Length: 925
• Species: Drosophila melanogaster
• Sequence 2: NP_075571.2
• Gene: CAPN10 / 11132
• HGNCID: 1477
• Length: 672
• Species: Homo sapiens
• Alignment Length: 544
• Identity: 157/544 - (28%)
• Similarity: 242/544 - (44%)
• Gaps: 110/544 - (20%)

  Fly   230 GRKATSARQNSVSKGDFQSLRDSCLANGTMFEDPDFPATNASL-------MYSRRPDRYYEWLRP 287
            ||.||.||:                    :|.|..|||.::||       :...|.|  ..|.||
Human     4 GRGATPARE--------------------LFRDAAFPAADSSLFCDLSTPLAQFRED--ITWRRP 46

  Fly   288 GDIADDPQFFVEGYSRFDVQQGELGDCWLLAAAANLTQDSTLFFRVIPPDQD--FQENYAGIFHF 350
            .:|...|:.|.:......|:||.|||||.|.|.|.|.:...|..:||||.|.  ..:.|.|.|..
Human    47 QEICATPRLFPDDPREGQVKQGLLGDCWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTC 111

  Fly   351 KFWQYGKWVEVVIDDRLPTYNGELIYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGTTCEAMED 415
            :.||:|:||||..|||||...|.|.:.....::.||..||||.|||:|||||.|..|...:|:.|
Human   112 RIWQFGRWVEVTTDDRLPCLAGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVD 176

  Fly   416 FTGGVTEWYDIK--------EAPPNLFS-----IMMKAAERGSMMGCSLEPDPHVLEAETPQGLI 467
            .|||:.|.:::|        :..|..:.     .::...::..:..|.|.|.....|      |.
Human   177 LTGGLAERWNLKGVAGSGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSPRAGARE------LG 235

  Fly   468 RGHAYSITKV---------CLMDISTPNRQGKLPMIRMRNPWGNDAEWSGPWSDSSPEWRFIPEH 523
            ..||:.::.:         |::            ::|::||||... |.|.|.:....|..:...
Human   236 EFHAFIVSDLRELQGQAGQCIL------------LLRIQNPWGRRC-WQGLWREGGEGWSQVDAA 287

  Fly   524 TKEEIGLNFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQHSSRRKWEMSMFEGEWTSGVT 588
            ...|: |:..::||||:..::||..||.:.:.....::......::.|.........|.|..|.:
Human   288 VASEL-LSQLQEGEFWVEEEEFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQS 351

  Fly   589 AGGCRNFLETFWHNPQYIISLEDPDDEDDDGKCTAIVALMQKNR--------RSKRNVGIDCLT- 644
            |||||| ...|..||::.:.:.:|.:        ..:|::|::|        |::..|| |..|
Human   352 AGGCRN-NSGFPSNPKFWLRVSEPSE--------VYIAVLQRSRLHAADWAGRARALVG-DSHTS 406

  Fly   645 -------------IGFAIYHLTDRDMQVKPQGLNFFKYRASVARSPHFINTREVCARFKLPPGHY 696
                         :|..::.:..|.:.: |:.|:.    ..||.:......|||..|.:|.||:|
Human   407 WSPASIPGKHYQAVGLHLWKVEKRRVNL-PRVLSM----PPVAGTACHAYDREVHLRCELSPGYY 466

  Fly   697 LIVPSTFDPNEEGEFIIRVFSETR 720
            |.|||||..:..|||::||||..|
Human   467 LAVPSTFLKDAPGEFLLRVFSTGR 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042	101/326 (31%)
		Calpain_III	574..721	CDD:279416	49/169 (29%)
		EF-hand_7	759..825	CDD:290234
		EFh	761..826	CDD:298682
		FRQ1	827..>908	CDD:227455
CAPN10	NP_075571.2	CysPc	2..319	CDD:238004	107/356 (30%)
		Domain III 1	322..494		50/184 (27%)
		Calpain_III	335..496	CDD:238132	49/171 (29%)
		Calpain_III	512..653	CDD:238132
		Domain III 2	513..654

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920