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Protein Alignment CalpB and CAPN9

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	XP_011542319.1	Gene:	CAPN9 / 10753	HGNCID:	1486	Length:	721	Species:	Homo sapiens

Alignment Length:	715	Identity:	322/715 - (45%)
Similarity:	449/715 - (62%)	Gaps:	66/715 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 LPY-PTAPPPESAPTQEEEPSVGVAELSFTSVKVPENQNMFWMGRKATSARQNSVSKGDFQSLRD 251
            :|| ..||.|::.|                   ||::            ||....|...|:.:|.
Human     1 MPYLYRAPGPQAHP-------------------VPKD------------ARITHSSGQSFEQMRQ 34

  Fly   252 SCLANGTMFEDPDFPATNASLMYSRRPDRYYEWLRPGDIADDPQFFVEGYSRFDVQQGELGDCWL 316
            .||..||:|||.||||:|:||.||.||...:.|.|||:|..:|:|.:.|.:|.|:.|||||||||
Human    35 ECLQRGTLFEDADFPASNSSLFYSERPQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWL 99

  Fly   317 LAAAANLTQDSTLFFRVIPPDQDFQENYAGIFHFKFWQYGKWVEVVIDDRLPTYNGELIYMHSTE 381
            |||.|:||.:.....||||.||.|...|||||||:|||:.:|::|||||||||:...|:::||.:
Human   100 LAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSAD 164

  Fly   382 KNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGGVTEWYDIKEAPPNLFSIMMKAAERGSM 446
            .|||||||||||||||:|||||||||:..||||||||||.|.:..||||.|.:.|:.||.:|||:
Human   165 HNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSL 229

  Fly   447 MGCSLEP-DPHVLEAETPQGLIRGHAYSITKVCLMDISTPNRQGKLPMIRMRNPWGNDAEWSGPW 510
            :||.::. .....||.||.|||:|||||:|.:..:..    |..::.:||:||||| ..||:|.|
Human   230 LGCFIDTRSAAESEARTPFGLIKGHAYSVTGIDQVSF----RGQRIELIRIRNPWG-QVEWNGSW 289

  Fly   511 SDSSPEWRFI-PEHTKEEIGLNFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQHSSRRKW 574
            ||||||||.: |...|.......| ||||||:|:||..|||:||||||:||:|.||..|    ||
Human   290 SDSSPEWRSVGPAEQKRLCHTALD-DGEFWMAFKDFKAHFDKVEICNLTPDALEEDAIH----KW 349

  Fly   575 EMSMFEGEWTSGVTAGGCRNFLETFWHNPQYIISLEDPDDEDDDGKCTAIVALMQKNRRSKRNVG 639
            |:::.:|.|..|.|||||||||:|||.|||..:||.:.|:..::  |:.:||||||:||..:..|
Human   350 EVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEE--CSFLVALMQKDRRKLKRFG 412

  Fly   640 IDCLTIGFAIYHLTDRDMQVKPQGLNFFKYRASVARSPHFINTREVCARFKLPPGHYLIVPSTFD 704
            .:.||||:|||...|:|..:..   :||:|.||.|||..|||.|||..|||||||.|:::||||:
Human   413 ANVLTIGYAIYECPDKDEHLNK---DFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFE 474

  Fly   705 PNEEGEFIIRVFSETRNNMEENDDEVGFGETDDRIAPSLPPPTPKEEDDPQRIALRRLFDSVAGS 769
            |::|.:|.:|:|||.:....:.|..|      |...|..|.|||.:::..:....|.||:.|||.
Human   475 PHQEADFCLRIFSEKKAITRDMDGNV------DIDLPEPPKPTPPDQETEEEQRFRALFEQVAGE 533

  Fly   770 DEEVDWQELKRILD---HSMRDVMVGSDGFSKDAV---RSMVAMLDKDRSGRLGFEEFEALLTDI 828
            |.||..:||:.:|:   ...:|:.     |.|.::   :::::::|...:|:|.|:||:.....:
Human   534 DMEVTAEELEYVLNAVLQKKKDIK-----FKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKL 593

  Fly   829 AKWRAVFKLYDTRRTGSIDGFHLRGALNSAGYHLNNRLLNALAHRYGSREGQIPFDDFLMCAIKV 893
            .:|..:|..:|..::|::..:.||.||.:||:.|::.||..:..||...|.|:.|||||.|.:::
Human   594 KQWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRL 658

Fly 894 893
Human 659 658

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.