Protein Alignment CalpB and CAPN9

DIOPT Version :10

• Sequence 1: NP_524016.4
• Gene: CalpB / 39165
• FlyBaseID: FBgn0025866
• Length: 925
• Species: Drosophila melanogaster
• Sequence 2: XP_011542319.1
• Gene: CAPN9 / 10753
• HGNCID: 1486
• Length: 721
• Species: Homo sapiens
• Alignment Length: 715
• Identity: 322/715 - (45%)
• Similarity: 449/715 - (62%)
• Gaps: 66/715 - (9%)

  Fly   188 LPY-PTAPPPESAPTQEEEPSVGVAELSFTSVKVPENQNMFWMGRKATSARQNSVSKGDFQSLRD 251
            :|| ..||.|::.|                   ||::            ||....|...|:.:|.
Human     1 MPYLYRAPGPQAHP-------------------VPKD------------ARITHSSGQSFEQMRQ 34

  Fly   252 SCLANGTMFEDPDFPATNASLMYSRRPDRYYEWLRPGDIADDPQFFVEGYSRFDVQQGELGDCWL 316
            .||..||:|||.||||:|:||.||.||...:.|.|||:|..:|:|.:.|.:|.|:.|||||||||
Human    35 ECLQRGTLFEDADFPASNSSLFYSERPQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWL 99

  Fly   317 LAAAANLTQDSTLFFRVIPPDQDFQENYAGIFHFKFWQYGKWVEVVIDDRLPTYNGELIYMHSTE 381
            |||.|:||.:.....||||.||.|...|||||||:|||:.:|::|||||||||:...|:::||.:
Human   100 LAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSAD 164

  Fly   382 KNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGGVTEWYDIKEAPPNLFSIMMKAAERGSM 446
            .|||||||||||||||:|||||||||:..||||||||||.|.:..||||.|.:.|:.||.:|||:
Human   165 HNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSL 229

  Fly   447 MGCSLEP-DPHVLEAETPQGLIRGHAYSITKVCLMDISTPNRQGKLPMIRMRNPWGNDAEWSGPW 510
            :||.::. .....||.||.|||:|||||:|.:..:..    |..::.:||:||||| ..||:|.|
Human   230 LGCFIDTRSAAESEARTPFGLIKGHAYSVTGIDQVSF----RGQRIELIRIRNPWG-QVEWNGSW 289

  Fly   511 SDSSPEWRFI-PEHTKEEIGLNFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQHSSRRKW 574
            ||||||||.: |...|.......| ||||||:|:||..|||:||||||:||:|.||..|    ||
Human   290 SDSSPEWRSVGPAEQKRLCHTALD-DGEFWMAFKDFKAHFDKVEICNLTPDALEEDAIH----KW 349

  Fly   575 EMSMFEGEWTSGVTAGGCRNFLETFWHNPQYIISLEDPDDEDDDGKCTAIVALMQKNRRSKRNVG 639
            |:::.:|.|..|.|||||||||:|||.|||..:||.:.|:..::  |:.:||||||:||..:..|
Human   350 EVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEE--CSFLVALMQKDRRKLKRFG 412

  Fly   640 IDCLTIGFAIYHLTDRDMQVKPQGLNFFKYRASVARSPHFINTREVCARFKLPPGHYLIVPSTFD 704
            .:.||||:|||...|:|..:..   :||:|.||.|||..|||.|||..|||||||.|:::||||:
Human   413 ANVLTIGYAIYECPDKDEHLNK---DFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFE 474

  Fly   705 PNEEGEFIIRVFSETRNNMEENDDEVGFGETDDRIAPSLPPPTPKEEDDPQRIALRRLFDSVAGS 769
            |::|.:|.:|:|||.:....:.|..|      |...|..|.|||.:::..:....|.||:.|||.
Human   475 PHQEADFCLRIFSEKKAITRDMDGNV------DIDLPEPPKPTPPDQETEEEQRFRALFEQVAGE 533

  Fly   770 DEEVDWQELKRILD---HSMRDVMVGSDGFSKDAV---RSMVAMLDKDRSGRLGFEEFEALLTDI 828
            |.||..:||:.:|:   ...:|:.     |.|.::   :::::::|...:|:|.|:||:.....:
Human   534 DMEVTAEELEYVLNAVLQKKKDIK-----FKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKL 593

  Fly   829 AKWRAVFKLYDTRRTGSIDGFHLRGALNSAGYHLNNRLLNALAHRYGSREGQIPFDDFLMCAIKV 893
            .:|..:|..:|..::|::..:.||.||.:||:.|::.||..:..||...|.|:.|||||.|.:::
Human   594 KQWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRL 658

  Fly   894  893
            Human   659  658

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_524016.4	PHA03247	<40..207	CDD:223021	6/19 (32%)
		Peptidase_C2	260..556	CDD:459889	168/297 (57%)
		Calpain_III	579..716	CDD:460050	70/136 (51%)
		EFh_PEF_CalpA_B	758..925	CDD:320071	44/142 (31%)
		EF-hand motif	758..786	CDD:320071	12/30 (40%)
		EF-hand motif	799..829	CDD:320071	6/32 (19%)
		EF-hand motif	830..860	CDD:320071	9/29 (31%)
		EF-hand motif	866..894	CDD:320071	12/28 (43%)
		EF-hand motif	895..925	CDD:320071
CAPN9	XP_011542319.1	Peptidase_C2	43..335	CDD:459889	168/297 (57%)
		Calpain_III	347..496	CDD:238132	77/157 (49%)
		EFh_PEF	522..662	CDD:355382	44/142 (31%)
		EF-hand motif	522..550	CDD:320067	12/27 (44%)
		EF-hand motif	565..594	CDD:320067	6/28 (21%)
		EF-hand motif	595..624	CDD:320067	8/28 (29%)
		EF-hand motif	631..659	CDD:320067	12/28 (43%)