DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpB and capn14

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	XP_031758480.1	Gene:	capn14 / 101732339	XenbaseID:	XB-GENE-22068150	Length:	722	Species:	Xenopus tropicalis

Alignment Length:	674	Identity:	239/674 - (35%)
Similarity:	360/674 - (53%)	Gaps:	40/674 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 RKATSARQNSVSKGDFQSLRDSCLANGTMFEDPDFPATNASL----MYSRRPDRYYEWLRPGDIA 291
            |..|..:...:...|:|:|.:..|....:|.|..|||:.||:    :..:.|| ..||.||.::.
Frog    24 RTGTLRKPRRLQSQDYQALLEKSLGGKQLFVDETFPASLASIGSGCLLDKLPD-CVEWKRPHELV 87

  Fly   292 DDPQFFVEGYSRFDVQQGELGDCWLLAAAANLTQDSTLFFRVIPPDQDFQENYAGIFHFKFWQYG 356
            .:|||..|..|.|.:.||...:||.|||.::||....:...|:|.:|.|.::|.|||||:||::|
Frog    88 QNPQFCTENASEFGLHQGLTENCWFLAALSSLTFHPDILTNVVPQNQSFNKSYGGIFHFRFWRFG 152

  Fly   357 KWVEVVIDDRLPTYNGE--LIYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGG 419
            :||:||:|||||. |||  |:::.|..||.||..|||||||||.||||.::.|...||:.|||||
Frog   153 EWVDVVVDDRLPV-NGEGKLLFVSSVRKNLFWGPLLEKAYAKLCGSYEDMQIGQVSEALVDFTGG 216

  Fly   420 VTEWYDIKEAPPNLFSIMMKAAERGSMMGCSLEPDPHVLEAETPQGLIRGHAYSITKVCLMDIST 484
            |.....:.:|||:||.|||:|...||:|||..:..|   |.....||:.||||::..|..:.:.:
Frog   217 VNMSIKMAQAPPDLFQIMMRAQNSGSLMGCQTQTGP---ERVLDNGLVTGHAYTVMDVRQVTVKS 278

  Fly   485 PNRQGKLPMIRMRNPWGNDAEWSGPWSDSSPEWRFIPEHTKEEIGLNFDR-DGEFWMSFQDFLNH 548
            ....    ::::|||||. .||:|.|||..|:|..:  ..||.:.|...| |||||||.:||..|
Frog   279 VTEN----LVKLRNPWGK-IEWTGKWSDRCPKWEQL--SYKERLFLRKRREDGEFWMSIEDFEAH 336

  Fly   549 FDRVEICNLSPDSLTEDQQHSSRRKWEMSMFEGEWTSGVTAGGCRNFLETFWHNPQYIISLEDPD 613
            |..:.||.|:||.::    |...::|.:||..|.|::|.||||...:.|::|.||||.:.:...|
Frog   337 FVELVICKLTPDLMS----HEIGKEWTLSMQCGRWSAGSTAGGRMTYTESYWLNPQYRLKILKGD 397

  Fly   614 D-EDDDGKCTAIVALMQKNRRSKRNVGIDCLTIGFAIYHLTDRDMQVKPQGLNFFKYRASVARSP 677
            | |.....|..:|:||||.....||.. ..|.||.:::.:......||.....||.....:....
Frog   398 DMEKFTNSCNVLVSLMQKQSHKHRNQS-PPLYIGMSVFLVPFEYQGVKRLPQKFFLTHRPINNKC 461

  Fly   678 HFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETRNNMEENDDEVGFGETDDRIAPS 742
            .|||.|||...:.|.||.|:|:|||.:||:|.|||:||||......|:.:            :|:
Frog   462 VFINEREVTQDYHLMPGSYVIIPSTAEPNQECEFILRVFSRKHLLQEQTE------------SPN 514

  Fly   743 LPPPTPKEEDDPQRIALRRLFDSVAGSDEEVDWQELKRILDH-SMRDVMVGSDGFSKDAVRSMVA 806
            :.....|..:..:.......|:.......|:...:|:::|:. :..:.......||.|..:.::|
Frog   515 IVLCCKKIAERHRNGIWETFFNKYFEKHPEIKVAQLQQLLNKITWTNSKQAPGKFSFDDCKLIMA 579

  Fly   807 MLDKDRSGRLGFEEFEALLTDIAKWRAVFKLYDTRRTGSIDGFHLRGALNSAGYHLNNRLLNALA 871
            :||...||.|..:||..|...:..::.:|:..|..:||.:....|:.|:...|..|:.:..|.:|
Frog   580 LLDMKTSGTLNMQEFRGLWKRLLSYQEIFQRRDVDKTGYLKLNDLQAAIKERGITLHRQFYNLVA 644

  Fly   872 HRYGSREGQIPFDDF--LMCAIKV 893
            .|||....::.|::|  ||..|::
Frog   645 LRYGDSLLKMSFENFACLMLRIEI 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042	133/302 (44%)
		Calpain_III	574..721	CDD:279416	58/147 (39%)
		EF-hand_7	759..825	CDD:290234	15/66 (23%)
		EFh	761..826	CDD:298682	16/65 (25%)
		FRQ1	827..>908	CDD:227455	18/69 (26%)
capn14	XP_031758480.1	Peptidase_C2	53..344	CDD:395523	133/302 (44%)
		Calpain_III	365..500	CDD:395848	52/135 (39%)
		EFh_PEF	532..668	CDD:355382	34/135 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010