DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpB and LOC100495980

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	XP_017952054.2	Gene:	LOC100495980 / 100495980	-ID:	-	Length:	737	Species:	Xenopus tropicalis

Alignment Length:	735	Identity:	300/735 - (40%)
Similarity:	439/735 - (59%)	Gaps:	55/735 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 PSVGVAELSFTSVKVPENQNMFWMGRKATSARQNSVSK---GDFQSLRDSCLANGTMFEDPDFPA 267
            |..|:      :|::.:.:|        :|||.| ||.   .|:..|...||....:||||.|||
Frog     2 PPSGI------TVRLQKEEN--------SSARHN-VSPYLGQDYHRLVQECLKQRQLFEDPHFPA 51

  Fly   268 TNASLMYSR-----RPDRYYEWLRPGDIADDPQFFVEGYSRFDVQQGELGDCWLLAAAANLTQDS 327
            .:.||.|:.     ...:..:|.||.:|...|||..|.....||.|||||:||.|||||:|||..
Frog    52 KSKSLGYNELGPFSENTKGIQWRRPQEICQSPQFICEDMKWTDVCQGELGNCWFLAAAASLTQYP 116

  Fly   328 TLFFRVIPPDQDFQENYAGIFHFKFWQYGKWVEVVIDDRLPTYNGELIYMHSTEKNEFWSALLEK 392
            .|..||:||.|.|:..|||||||:|||||:||:||:|||||...|||:::.|.:|:|||:|||||
Frog   117 LLKERVVPPQQSFKSGYAGIFHFQFWQYGEWVDVVVDDRLPVKEGELVFVSSAQKSEFWAALLEK 181

  Fly   393 AYAKLHGSYEALKGGTTCEAMEDFTGGVTEWYDIKEAPPNLFSIMMKAAERGSMMGCSLEPDPH- 456
            |||||:||||||.||...||..|||||:.|...:||.|||||.::.||.::.|:||..::|...
Frog   182 AYAKLNGSYEALNGGFMNEAFVDFTGGLGETVKLKETPPNLFHLLQKAVKKKSLMGAFIQPQSQS 246

  Fly   457 VLEAETPQGLIRGHAYSITKVCLMDISTPNRQGKLPMIRMRNPWGNDAEWSGPWSDSSPEWRFIP 521
            .:|.:||:||:.||||||.....|    .|...|:|::|:|||||. .||:|.|||.|..|..:.
Frog   247 QIENQTPEGLLTGHAYSIIATWEM----KNNGKKIPLLRLRNPWGR-VEWNGHWSDDSTLWSQVD 306

  Fly   522 EHTKEEIGLNFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQHSSRRKWEMSMFEGEWTSG 586
            ...::::.:. ..||||||..:|||..||.:|:|||:|:|:|:  :|:  :.|:.:.|.|.|. |
Frog   307 PEIRKKLQVR-GEDGEFWMQMEDFLRFFDILEVCNLTPESVTD--KHA--QLWKTNTFCGRWL-G 365

  Fly   587 VTAGGCRNFLETFWHNPQYIISLEDPDDEDDDGKCTAIVALMQKNRRSKRNVGIDCLTIGFAIYH 651
            .:|||||.:.:|||.|||::::|.: .||:..|.||.:|:|||||||..|::|.|.|::||.||.
Frog   366 HSAGGCRTYKDTFWTNPQFLVTLTE-QDEEKHGMCTLLVSLMQKNRRQCRSIGQDFLSVGFEIYQ 429

  Fly   652 LT---DRDMQVKPQGLNFFKYRASVARSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFII 713
            :.   |..| ...:..|.|....||| |..|::.|:|..|::||||.||::||||.|::|.:||:
Frog   430 VPKEFDNKM-CASERKNLFSSLVSVA-SCSFMDERDVTGRYQLPPGRYLLIPSTFQPHQESDFIM 492

  Fly   714 RVFSETRNNMEENDDEVGFGETDDRIAPSLPPPTPKEEDDPQRIALRRLFDSVAGSDEEVDWQEL 778
            |:|:|.::...|.|.|:   ..:..:..........||...|       |..::|.|:|:..:||
Frog   493 RIFTEKQHTFIEIDCEI---RANGNVFKENALKDTMEEFSAQ-------FARLSGEDQEISPEEL 547

  Fly   779 KRIL-DHSMRDVMVGSDGFSKDAVRSMVAMLDKDRSGRLGFEEFEALLTDIAKWRAVFKLYDTRR 842
            :||| ..:.::..:.::|||.|..|.:|.|:|.:.:|:|..|||..|.:.|.:|..:|..||..|
Frog   548 QRILIQITSKNTHLKTNGFSLDICRKLVKMVDLNCNGKLQLEEFRKLWSKIKEWEKIFTNYDKDR 612

  Fly   843 TGSIDGFHLRGALNSAGYHLNNRLLNALAHRYGSREGQIPFDDFLMCAIKVRTFIEMFRERDTDN 907
            :|::|...|..||.:||:.|||:|:.:|..:||:...|:.||.||.|...:....|..|..|.:.
Frog   613 SGTMDVQELCLALEAAGFTLNNQLVESLCQKYGNNVRQVYFDSFLSCLAYLVCVFEQCRIMDKNK 677

  Fly   908 SDTAFFNLDD---WLERTIY 924
            ......:.::   :::.|||
Frog   678 DGVICISKEEASIYIKGTIY 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403	3/18 (17%)
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042	151/301 (50%)
		Calpain_III	574..721	CDD:279416	67/149 (45%)
		EF-hand_7	759..825	CDD:290234	22/66 (33%)
		EFh	761..826	CDD:298682	23/65 (35%)
		FRQ1	827..>908	CDD:227455	29/80 (36%)
LOC100495980	XP_017952054.2	Peptidase_C2	44..340	CDD:395523	151/301 (50%)
		Calpain_III	361..495	CDD:395848	63/137 (46%)
		EFh_PEF	527..687	CDD:355382	54/166 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D87342at33208
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010